Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-CoronavirusReview Published on 2020-12-302022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, SARS, [키워드] antiviral activity candidate clinical study combating conducted database Dengue dengue virus described Diseases Efficacy eight ethnobotany Euphorbia Extensive form Human In vitro studies in vivo Infection infections inhibit inhibiting investigated medicinal plants pandemic Pharmacology phytochemical plant Potential regions reported respiratory reveal Safe SARS-CoV SARS-CoV infections serotypes shown survival were used while [DOI] 10.3390/biom11010042 PMC 바로가기 [Article Type] Review
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main proteaseResearch Article Published on 2020-12-032022-10-04 Journal: Heliyon [Category] 신약개발, [키워드] Anti-SARS-CoV-2 Activity ARB ARBs Azilsartan binding affinity binding free energy Biological Biological sciences blocker Blood coagulation carried Chemistry clinical study Combination Compound compounds computer Computer science COVID-19 COVID-19 pandemic COVID-19 virus disease docked docking drug Drug repurposing drugs targeting effective drug Effectiveness eprosartan fibrosis in vitro In vitro studies Inflammation inhibit Irbesartan material Materials science MD MM-GBSA molecular N3 inhibitor nine olmesartan pandemic coronavirus Patient patients worldwide Physics Prevent profiles Prophylactic protease pulmonary fibrosis receptor reduce required SAR SARS-CoV-2 SARS-CoV-2 protease Science telmisartan tested Treatment valsartan vasodilatation VERO E6 cells Virtual screening was performed [DOI] 10.1016/j.heliyon.2020.e05641 PMC 바로가기 [Article Type] Research Article
Perspectives in Peptide-Based Vaccination Strategies for Syndrome Coronavirus 2 PandemicPharmacology Published on 2020-12-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome approach approved breath caused characterized clinical trials Coronaviridae coronavirus coronavirus 2 Coronavirus infection COVID-19 COVID-19 infection COVID-19 pandemic demonstrated develop drug candidate Efficacy effort enveloped RNA virus Epidemic Epidemics epitope expected feature Health health emergency high mortality rate highlight Host immune response host-pathogen interaction Human human cell human CoV infection human immune response immunogenic In vitro studies induce infect Infection Interaction Laboratory majority mammals membrane MERS-CoV Middle East Mild molecular basis Nucleocapsid proteins other coronaviruses peptide peptide on market peptide-based peptide-based vaccine Region Research respiratory respiratory tract infection Safe SARS-CoV SARS-CoV-2 severe pneumonia shown specificity Spread Strategy syndrome targets therapeutic strategy Treatment unique Vaccine Vaccine development viral pathogen virus World Health Organization Wuhan, China [DOI] 10.3389/fphar.2020.578382 PMC 바로가기 [Article Type] Pharmacology
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Triggering a Lethal Fight to Keep Control of the Ten-Eleven Translocase (TET)-Associated DNA Demethylation?Review Published on 2020-11-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accounted activities activity acute respiratory syndrome adjacent sequences affected bimodal binding site cellular children clinical symptom complex Control coronavirus coronavirus 2 correlation COVID-19 deregulation DNA DNA methylation enzyme Factor function Gene Expression high mortality higher risk homeostasis Host hypoxia in vitro In vitro studies inactivation include intestinal Keep lethal liver mortality rate neuronal Patient patients promoters proteasomal Protein regulated Regulation Regulatory respiratory responsible SARS-CoV-2 selective Symptom Symptoms TET TET enzymes TET2 translocase viral invasion virus inactivation women X chromosome Xist [DOI] 10.3390/pathogens9121006 PMC 바로가기 [Article Type] Review
COVID-19 in Patient with Sarcoidosis Receiving Long-Term Hydroxychloroquine Treatment, France, 2020Research Letter Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, [키워드] 2019 novel coronavirus disease adequate plasma concentrations coronavirus coronavirus disease COVID-19 curative treatment evaluated France Hydroxychloroquine hydroxychloroquine treatment In vitro studies Patient plasma concentration Postexposure Prophylaxis receiving respiratory infections sarcoidosis SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses zoonoses [DOI] 10.3201/eid2610.201816 PMC 바로가기 [Article Type] Research Letter
Imaging Diagnostics and Pathology in SARS-CoV-2-Related DiseasesReview Published on 2020-09-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Algorithm applied artificial intelligence association Chinese Clinical data concerning Coronavirus-2 diagnostic procedure drug effort evaluated global pandemic histopathological imaging imaging diagnostic In vitro studies in vivo Infection Interpretation Invasion kidney lung mechanisms nuclear organ outbreak pandemic pathology Patient physician Pneumonia protocol provided Replication reported SARS-CoV-2 Scientific community Support the SARS-CoV-2 Treatment ultrastructure Vascular WHO World Health Organization Wuhan [DOI] 10.3390/ijms21186960 PMC 바로가기 [Article Type] Review
A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19Remdesivir에 대한 검토: COVID-19 치료를 위한 잠재적인 약제Review Published on 2020-08-062022-09-11 Journal: Drug design, development and therapy [Category] 비임상, [키워드] (RdRp 2019-nCoV active form acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine triphosphate agent animal model animal models ATP breath cause caused Characteristics clinical trial clinical trials competing coronavirus COVID-19 demonstrated development disease drug Ebola virus effective effective therapy Efficacy epithelial cells Google Scholar GS-5734 Human in vitro In vitro studies in vitro study information inhibit management MERS MERS coronaviruses Novel coronavirus nucleoside nucleoside triphosphate phosphoramidate prodrug RdRP Remdesivir respiratory respiratory epithelial cell respiratory epithelial cells review RNA RNA polymerase RNA-dependent RNA polymerase SARS and MERS coronaviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus time-consuming treat Treatment treatment of COVID-19 Vaccine Viral viral replication Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.2147/DDDT.S261154 PMC 바로가기 [Article Type] Review
Lithium’s antiviral effects: a potential drug for CoViD-19 disease?Review Published on 2020-05-202022-10-30 Journal: International Journal of Bipolar Disorders [Category] COVID-19, [키워드] addition addressed affecting affective anatomical Antiviral antiviral activity antiviral efficacy antiviral property Bipolar disorder clinical evidence clinical settings clinical study Concentration condition continuous monitoring Coronaviridae coronavirus demonstrated disorders DNA and RNA Evidence GSK-3β heterogeneous In vitro studies inhibit Inositol involved kidney lithium mechanism observation pathway Pathways pleiotropic Prevent reduction Serum level Side effects Thyroid tissues Tolerability Toxicity translate Treatment viral infection virus viruses [DOI] 10.1186/s40345-020-00191-4 PMC 바로가기 [Article Type] Review
Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidenceReview Published on 2020-03-272022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] acute respiratory syndrome adverse events anti-CD20 auto-immune disease blockade blockers Cancer Chemotherapy coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Cytokines Cytotoxic chemotherapy drug drugs Effect elevated Evidence higher risk host immunity IL-1 IL-6 IL-6 inhibitor immune modulation Immune suppression Impact In vitro studies induce inhibitor inhibitors Jak JAK-STAT pathway Janus kinase Kinase inhibitor less low-dose methotrexate modulation Necrosis non-steroidal anti-inflammatory drug NSAIDS OVID Patient patients patients with COVID-19 Prednisolone pro-inflammatory cytokine pulmonary complications respiratory diseases Result secretion severity shown Steroids systematic review target TNFα treated Treatment [DOI] 10.3332/ecancer.2020.1022 PMC 바로가기 [Article Type] Review
In Vitro Data of Current Therapies for SARS-CoV-2Article Published on 2020-01-012023-07-05 Journal: Current medicinal chemistry [Category] SARS, [키워드] ACE2 receptor In vitro studies SARS-CoV-2 (COVID-19) Therapies Vaccines VeroE6 cells [DOI] 10.2174/0929867327666200513075430