Future of Therapy for Inborn Errors of ImmunityArticle Published on 2022-01-122024-09-04 Journal: Clinical reviews in allergy & immunology [Category] 대상포진, [키워드] fusion protein Gene therapy inborn errors of immunity monoclonal antibodies newborn screening Primary Immunodeficiency Small molecule inhibitors [DOI] 10.1007/s12016-021-08916-8 PMC 바로가기 [Article Type] Article
Congenital and acquired defects of immunity: An ever-evolving story면역의 선천적 및 후천적 결함: 끊임없이 진화하는 이야기Article Published on 2022-01-012022-09-11 Journal: Pediatric allergy and immunology : official public [Category] SARS, 변종, [키워드] congenital Defense deficiency described disease disorder disorders DNA sequencing genomic data Host host defense immune immune regulation Immunity immunodeficiency immunodeficiency disorders Inborn Inborn errors inborn errors of immunity Interpretation involved Mutation new monogenic diseases of immunity PID Primary Immunodeficiency Primary immunodeficiency disorders referred to reported SASH3 severe COVID-19 Signaling T-cell receptor TCR [DOI] 10.1111/pai.13632 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learnedArticle Published on 2021-12-222023-07-01 Journal: Current opinion in pediatrics [Category] SARS, [키워드] Coronavirus disease 2019 inborn errors of immunity Primary Immunodeficiency severe acute respiratory syndrome coronavirus 2 [DOI] 10.1097/MOP.0000000000001062 PMC 바로가기
Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibody Deficiency사례 시리즈: COVID-19 및 1차 항체 결핍 환자를 위한 회복기 혈장 요법Original Article Published on 2021-12-102022-09-12 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibody appear applied benefit Clinical symptoms Cohort common variable immunodeficiency convalescent plasma convalescent plasma treatment country Course COVID-19 COVID19 patient deficiency demonstrated Effectiveness Evidence Fever Follow-up Hypogammaglobulinemia immunocompromised individual immunocompromised individuals inborn errors of immunity Infection longitudinal many case many cases monoclonal antibody Mutation one patient option Patient PCR plasma primary antibody Primary immunodeficiencies reduction in resolved risk Safe SARS-CoV-2 Sequencing Side effect supplementary material Therapeutic benefit Therapies treated Treatment viral genome Viral load Viral RNA shedding viral shedding while with COVID-19 [DOI] 10.1007/s10875-021-01193-2 PMC 바로가기 [Article Type] Original Article
Molecular Tuning of Actin Dynamics in Leukocyte Migration as Revealed by Immune-Related ActinopathiesReview Published on 2021-11-152023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Actin actin regulators Cell migration chemotaxis cytoskeleton IEI inborn errors of immunity leukocytes [DOI] 10.3389/fimmu.2021.750537 PMC 바로가기 [Article Type] Review
Antibody responses to the SARS-CoV-2 vaccine in individuals with various inborn errors of immunity다양한 선천성 면역 오류가 있는 개인의 SARS-CoV-2 백신에 대한 항체 반응Article Published on 2021-11-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] adverse event adverse events affected age anti-S anti-S IgG anti-S IgG levels antibody Antibody Response Antibody titer Antibody titers Autoimmune B cells B-cell baseline candidiasis Care CD19 CD3 Cohort cohort of patient completion controls counseling COVID-19 COVID-19 vaccine Diagnosis dose evaluate Genetic Health Health care immune immune suppressants Immunity immunization immunization schedule immunized immunogenicity immunomodulators immunosuppressive drug immunosuppressive drugs Inborn errors inborn errors of immunity individual information Jak jak inhibitors janssen Johnson & Johnson less luciferase Luciferase immunoprecipitation system median medical records mRNA vaccine Patient patients plasma rate of seroconversion reported rituximab Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose Seroconversion single dose subsequent T cells the SARS-CoV-2 therapy These data thymoma Treatment Vaccinating Vaccine was collected were measured [DOI] 10.1016/j.jaci.2021.08.016 PMC 바로가기 [Article Type] Article
X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-TelangiectasiaX-연관 TLR7 결핍은 운동실조-모세혈관확장증 남성 환자의 심각한 COVID-19 폐렴의 원인이 됩니다Case Reports Published on 2021-10-232022-09-10 Journal: Journal of Clinical Immunology [Category] MERS, 변종, 유전자 메커니즘, 치료기술, [키워드] antibody Antibody deficiency Asymptomatic Ataxia ataxia-telangiectasia ATM autoantibodies autoantibody candidate gene clinical manifestations conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 immune response COVID-19 pneumonia Critical critical COVID-19 deficiencies deficiency Deleterious Diagnosis disease evaluated exhibit Exome genetic cause genetic defect genetic defects high risk homozygous identify IFNs IgM immune response Immunity Impact inborn errors of immunity individual interferons investigated life-threatening mechanism Mild symptom mild symptoms Mutation neurological signs objective Patient patients evaluated Pneumonia Primary Immunodeficiency radiosensitivity Result SARS-COV-2 infection Sequencing serum levels specific antibodies specific antibody supplementary material syndrome telangiectasia the patient TLR7 TLR7 gene Treatment Type I IFN type I interferon type I interferons underlie understanding unique variant virus was performed were measured [DOI] 10.1007/s10875-021-01151-y PMC 바로가기 [Article Type] Case Reports
Humoral and Cellular Response Following Vaccination With the BNT162b2 mRNA COVID-19 Vaccine in Patients Affected by Primary ImmunodeficienciesImmunology Published on 2021-10-042022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] affected anti-SARS-CoV-2 antigen-specific T cell BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine cellular response cohort of patient Comirnaty conducted COVID-19 COVID-19 vaccine develop dose Efficacy Efficacy and safety global pandemic group healthy healthy control high risk humoral Immunity inborn errors of immunity include mass Patient Population protective immunity quantification raise response SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV2 vaccine severe COVID-19 significant increase statistically significant subpopulation T cell T cells the vaccine Trial vaccination Vaccine vaccine efficacy Vaccine-induced immunity [DOI] 10.3389/fimmu.2021.727850 PMC 바로가기 [Article Type] Immunology
A Prospective Survey of Skin Manifestations in Children With Inborn Errors of Immunity From a National Registry Over 17 YearsOriginal Research Published on 2021-09-302024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Autoimmunity Cutaneous infections eczematoid rashes immunodeficiency inborn errors of immunity non-infectious cutaneous granulomas skin manifestations [DOI] 10.3389/fimmu.2021.751469 PMC 바로가기 [Article Type] Original Research
Neuron-intrinsic immunity to viruses in mice and humansArticle Published on 2021-08-122024-09-04 Journal: Current opinion in immunology [Category] 대상포진, [키워드] cell-intrinsic immunity human pluripotent stem cells inborn errors of immunity Mouse models neurons viral infection [DOI] 10.1016/j.coi.2021.07.004 PMC 바로가기 [Article Type] Article