Clinical efficacy of COMPASS, a digital cognitive-behavioural therapy programme for treating anxiety and depression in patients with long-term physical health conditions: a protocol for randomised controlled trial장기 신체 건강 상태를 가진 환자의 불안과 우울증을 치료하기 위한 디지털 인지-행동 치료 프로그램인 COMPASS의 임상 효능: 무작위 대조 시험을 위한 프로토콜Article Published on 2021-10-252022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 access All participant All participants allocation concealment analysed Anxiety anxiety disorders approved baseline blinded to treatment clinical Clinical efficacy clinical trials collected college COMPASS conducted conferences confidence consequence Controlled trial COVID-19-related distress data analyst Depression depression & disorders distress Efficacy eligible Ethics evaluate finding FIVE Health health condition healthcare services independent individual Informed consent intention-to-treat principle interview King knowledge life London LTC LTCs mental health problem mental health problems Midwifery mood disorders National Nursing parallel-group participant Patient peer-reviewed physical Primary outcome protocol Psychological distress psychological treatment Quality of life Qualtrics randomisation randomised controlled trial Randomly receive recruited reducing registration number Research Ethics scale SCS secondary outcome Secondary outcomes Self-management Support symptom severity therapy Treatment treatment allocation Two-arm [DOI] 10.1136/bmjopen-2021-053971 PMC 바로가기 [Article Type] Article
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trialSARS-COV-2 감염 (COVID-RED)의 원격 조기 발견을위한 일일 증상 일기 외에 웨어러블 장치의 효과를 조사하기위한 전향 적, 무작위, 단일 맹장, 크로스 오버 시험 : 연구의 구조적 요약.무작위 제어 시험을위한 프로토콜Update Published on 2021-10-112022-09-01 Journal: Trials [Category] MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] 1:1 addition adhere Algorithm Algorithms all subject all subjects among others analysed antibody Antibody testing antibody tests Antigen antigen tests approach asked assigned Asymptomatic asymptomatic individual asymptomatic infection average baseline blinded Blinding can not capillary blood Chain Reaction changes in Characteristics cholinergic urticaria Cohort collected Complete conditions conducted consent form contribute control condition COVID-19 COVID-19 infection COVID-19 vaccination current Daily defined demographics described detect detection determine develop deviation diary dissemination Early detection element eligibility criteria eligible End enrolled enrolment evaluate exclusion exploratory feedback Follow-up followed by gold gold standard Health health resource heart rate incidence rates Inclusion inclusion criteria individual individuals infected individual infected individuals infected with SARS-CoV-2 Infection information Informed consent informed consent form initial involved Laboratory laboratory-confirmed SARS-CoV-2 infection machine learning management maximum media medical history Mobile application must nasal swab National natural infection Negative predictive value Netherland Netherlands notification NPV number objective occur outcome pacemaker parameter participant PCR PCR test PCR tests physiological physiological parameters polymerase chain polymerase chain reaction populations portal positive Positive predictive value PPV pre-symptomatic Predictive value primary analysis profession proportion Prospective protocol provided public health Pulse rate questionnaire randomization randomization sequence Randomized Randomized controlled trial Randomly receive recommendation recruited recruitment reduce remote reported resident resource responsible resulting risk RIVM Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 test SARS-CoV-2 virus sensitivity sequence sequence 1 Sequence 2 sequences serology serology test serology tests significantly skin temperature Smartphone social media specificity staff stratified stratified block randomization study participation Study protocol subject suffering supplementary material Symptom Symptom diary Symptoms target temperature test result tested the SARS-CoV-2 thought Transmission transmissions Trial Trial registration undergo urticaria used to evaluate vaccinated against COVID-19 vaccination Vaccine Variability wearable device website Well-being [DOI] 10.1186/s13063-021-05643-5 PMC 바로가기 [Article Type] Update
Food insecurity arises the likelihood of hospitalization in patients with COVID-19Article Published on 2021-10-082022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] Affect age analyzed arise Chi-square confounding variables Corona COVID-19 COVID-19 patient cross-sectional diagnosed examined food food insecurity Health policy Hospital stay Hospitalization Hospitalized Infectious diseases Informed consent Iran likelihood Logistic regression male not significantly different nutrition pandemic Patient patients with COVID-19 Probability public health public health emergency Quality of life questionnaire secure significantly significantly more t-test the mean two group was performed WHO World Health Organization [DOI] 10.1038/s41598-021-99610-4 PMC 바로가기 [Article Type] Article
Protecting privacy in mandatory reporting of infectious diseases during the COVID-19 pandemic: perspectives from a developing countryArticle Published on 2021-10-052023-06-17 Journal: Journal of medical ethics [Category] MERS, [키워드] confidentiality/privacy COVID-19 Informed consent law public law [DOI] 10.1136/medethics-2021-107372 PMC 바로가기
COVID-19: persistence of symptoms and lung alterations after 3-6 months from hospital dischargeCOVID-19: 퇴원 후 3-6개월 후에도 증상 지속 및 폐 변형Article Published on 2021-10-012022-09-11 Journal: Infection [Category] SARS, 치료기술, [키워드] abnormality alteration alterations anamnesis Anxiety blood tests carbon monoxide changes in Coagulation parameters COVID-19 COVID-19 patient COVID-19 patients Deep vein Deep vein thrombosis diffusing diffusing capacity diffusion discharged DLCO Dyspnea ECG evaluate Evolution exertional dyspnea Extended fatigue fibrinogen Follow-up highlight hospital discharge Inflammatory Informed consent Insomnia lower limb lung lung capacity Lung ultrasound males Mild organ damage Patient persistence Physical examination Prospective Study questionnaire recruited reduced refusal reported required Residual symptoms significantly spirometry suffered Symptom Symptoms the median Thoracic thrombosis venous were excluded [DOI] 10.1007/s15010-021-01638-1 PMC 바로가기 [Article Type] Article
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial중등도에서 중증 ARDS 환자의 폐 투과성 부종을 치료하기 위해 순차적으로 다중 상승하는 solnatide의 안전성 및 예비 효능 - 무작위, 위약 대조, 이중 맹검 시험Randomized Controlled Trial Published on 2021-09-202022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] acquisition acute respiratory distress syndrome administer alveolar animal model animal models ARDS ARDS patients breath clinical Clinical diagnosis clinical trial collected comatose complex Course Critical care data safety monitoring board decarboxylation diffusion distress dose double-blind double-blind trial edema Efficacy eligible patient Eligible patients Endpoint etiologies EU Clinical Trials EudraCT Extravascular lung water follow-up period for inclusion healthy Human Inclusion Informed consent Inhaled Intervention leads mechanical ventilation moderate moderate to severe monitoring board multiple ascending dose Oxygenation parallel group Particular pathway Patient patient safety peptide phase Phase I clinical trial Placebo placebo-controlled protocol Pulmonary edema pulmonary permeability Randomized receiving reduce Registered respiratory distress Respiratory distress syndrome Safe Safety sedated severe ARDS shown sick Solnatide syndrome treat Trial Trial registration [DOI] 10.1186/s13063-021-05588-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Study protocol for a randomised controlled trial of enhanced informed consent compared to standard informed consent to improve patient understanding of early phase oncology clinical trials (CONSENT)초기 단계의 종양학 임상 시험(CONSENT)에 대한 환자의 이해를 향상시키기 위한 표준 사전 동의와 비교하여 향상된 사전 동의의 무작위 대조 시험에 대한 연구 프로토콜Article Published on 2021-09-062022-09-11 Journal: BMJ Open [Category] SARS, 임상, 치료기술, 치료제, [키워드] administration age Alpha approval Cancer clinical trial clinical trials Consent demonstrated detect development drug early phase eligible Ethics experimental arm exposure to followed by full length Health Research Authority IMPROVE increasingly information Informed Informed consent investigator-initiated measure medical ethics National Health Service number oncology Part Patient Patient education patient selection primary endpoint protocol Quality questionnaire randomised controlled trial REC reference reflected registration number Research Result standard treatment stratified t-test Trial trials unit [DOI] 10.1136/bmjopen-2021-049217 PMC 바로가기 [Article Type] Article
Antiviral and immunomodulatory interferon-beta in high-risk COVID-19 patients: a structured summary of a study protocol for a randomised controlled trial고위험 COVID-19 환자의 항바이러스 및 면역조절 인터페론-베타: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-032022-09-10 Journal: Trials [Category] 임상, 치료제, [키워드] acting Acute respiratory failure acutely ill patient acutely ill patients addition Admission age allergy anamnesis antiretroviral Antiviral Antiviral treatment approach ARMS assigned Asthma Autoimmune disease AVPU being binding antibody Blinding block blocks blood pressure blood sample bridge calculated Care cartridge Chemotherapy chronic kidney diseases clinical assessment Clinical Center clinical centers Clinical deterioration clinical monitoring Clinical sign conducted Control control arm control group control patients Controlled COVID-19 COVID-19 symptoms crackles creatinine criteria cytokine Darmstadt Day death Dementia determined by diagnosed disease Disease progression dissemination dose Efficacy EGFR Elderly patient element eligible Eligible patients Endpoint enrolled enrolment EudraCT evaluate Evidence evidence of exclusion criteria expected experimental arm female following form Gender Germany Health heart rate High-dose HIV infection Hospitalized hospitalized patients hypersensitivity ICU identification number IFN IFN-β IFNβ immunomodulation immunomodulatory immunomodulatory property immunosuppressive Impaired impairing inclusion criteria increase in Infectious disease Infectious diseases Informed consent injected injection intensive care unit interferon Interferon-beta investigator involved kidney laboratory-confirmed SARS-CoV-2 infection Lazzaro Spallanzani less level of care Life expectancy low-dose male management mechanical ventilation mild COVID-19 symptom mild COVID-19 symptoms multiple sclerosis Nasopharyngeal swab nasopharyngeal swabs National Early Warning Score NEWS2 non-hospitalized patients normal range number objective Older open Open-label outcome oxygen oxygen saturation participant Patient patient identification patients patients treated PCR performed phase physical physician Presence primary endpoint proportion protocol provide Psychological pulse rales randomised randomised controlled trial randomization randomization system Randomized Randomly receive recruitment reducing reduction in Regional registration date relapsing renal function Respiratory failure respiratory rate responsible resulting risk Rome room air RT-PCR Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR score Secondary objective Secondary objectives selected sequence severe COVID-19 severe depression severe disease specimen SpO2 Standard of care status stratified Stratified randomization Study protocol subcutaneously subject supervision supplemental oxygen supplementary material symptomatic temperature Toxicity treat Treatment treatment arm treatment group Trial Trial registration unique unit venous venous blood Version vital signs website Withdrawal worsening written Informed Consent [DOI] 10.1186/s13063-021-05367-6 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 Infection Rate in Patients With Cancer and Health Care Workers in a Chemoradiotherapy Unit During the Pandemic: A Prospective Cohort in Mexico팬데믹 기간 동안 화학방사선치료실에서 암 환자 및 의료 종사자의 SARS-CoV-2 감염률: 멕시코의 예상 코호트Article Published on 2021-09-012022-09-11 Journal: JCO Global Oncology [Category] SARS, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 immunoglobulin antibody Asymptomatic asymptomatic infections baseline Biweekly Cancer cancer treatment center Chain Reaction chemoradiotherapy clinical questionnaire contagious COVID-19 COVID-19 pandemic COVID-19-related symptom COVID-19-related symptoms cumulative death detect determine diagnostic events Follow-up HCW Health care Health care worker health care workers Hospitalization IgG Immunoglobulin Immunoglobulin G incidence infection rate Informed consent Interaction likelihood ratio median Mexico City Nasopharyngeal swab nasopharyngeal swabs outcomes Participants Patient patient safety Patients with cancer performed polymerase chain polymerase chain reaction positive Positive predictive value positive RT-PCR Predictive value Prevent Prospective provided Quantitative Rate receive reverse transcriptase Reverse transcriptase polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection sensitivity Seroconversion seroconversion rate solid tumor solid tumors study period transcriptase Transmission Treatment tumors unit was performed were measured were recorded worker [DOI] 10.1200/GO.21.00207 PMC 바로가기 [Article Type] Article
Application of a Cloud Video Conference Method for Recruiting Healthy Subjects Into an Early-Phase Clinical Trial During the COVID-19 PandemicPublic Health Published on 2021-08-192022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] All participant application clinical clinical trial cloud Conference COVID-19 COVID-19 epidemic COVID-19 pandemic early phase clinical trial Effect evaluated exhibit expressed healthy volunteers help ICF Infection Informed consent informed consent form knowledge participant participated question questionnaire reducing risk subject Travel Trial video informed process [DOI] 10.3389/fpubh.2021.657804 PMC 바로가기 [Article Type] Public Health