A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity유리한 생체 분포 패턴과 유망한 면역성을 지닌 코어 쉘 구조의 COVID-19 mRNA 백신Article Published on 2021-05-312022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 비임상, 임상, 진단, 치료제, [키워드] addition administration biodistribution composed COVID-19 COVID-19 vaccine COVID-19 vaccines Critical D614G effective effective vaccine Extensive facilitate full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein humans Immunity inoculation intramuscular levels of antibody liver LPP mice mRNA mRNA vaccine N501Y Neutralizing non-human primate non-human primates packaged Protein Safe SARS-CoV-2 spike Spike protein stability T cell T cell response Translational research unique Vaccine vaccine candidate Vaccines variant variants wild-type SARS-CoV-2 [DOI] 10.1038/s41392-021-00634-z PMC 바로가기 [Article Type] Article
The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model위장관은 비인간 영장류 모델에서 SARS-CoV-2 감염에 대한 대체 경로입니다Article Published on 2021-04-012022-09-11 Journal: Gastroenterology [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caspase 3 caused CD68 Chain Reaction change cleaved Clinical sign Clinical signs connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines digestive dysfunction evaluated fecal Fecal-Oral Route Gastrointestinal GI Tract goblet cells Histopathology host responses Hypothesis immunohistochemistry increased expression increasingly Infection Inflammation Inflammatory cytokines inoculation intranasal investigated involved Ki67 lung macrophages manifestation Model mucin NHP Pathogenesis pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathologic Patient periodic acid Pneumonia polymerase chain polymerase chain reaction primate quantified Quantitative reported respiratory respiratory tissue respiratory tissues response reverse transcription rhesus Rhesus monkeys route SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe infections staining tissue tissues tract Viral viral genomic RNA viral infection were infected were recorded [DOI] 10.1053/j.gastro.2020.12.001 PMC 바로가기 [Article Type] Article
Experimental Inoculation of Young Calves with SARS-CoV-2SARS-CoV-2 어린 송아지 실험 접종Article Published on 2021-03-092022-09-10 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 receptor age analyses angiotensin angiotensin I Blood bovine calf cattle collected Course criteria determine distribution enzyme euthanasia evaluate exposure to facilitated host range implicated Infectious virus inoculated inoculation International intravenous kidney liver Lungs Lymph node nasal swab necropsy not recovered nucleic acid PCR cycle performed positive Protein Pyrexia receptor rectal swab replication of SARS-CoV-2 reported SARS-CoV-2 SARS-CoV-2 RNA Scientific community sequence Seroconversion Structural analysis susceptibility susceptible threshold tissue tissue sample tissue samples tissues tracheobronchial Urine Viral viral shedding Viremia virus was used [DOI] 10.3390/v13030441 PMC 바로가기 [Article Type] Article
Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2SARS-CoV-2의 단일 균주의 비강 내 저용량으로 햄스터 및 흰 족제비 실험 감염Article Published on 2021-03-012022-09-11 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Antiviral strategies Brain can be used clinical disease COVID-19 drugs excretion experimental animal model experimental model experimental models ferret ferrets French hamster hamsters immune response immune responses in vivo individual Infection infection levels inoculation intranasal Kinetics low dose lung Lungs Medulla oblongata Mild oblongata olfactory olfactory bulb Pathogenesis pathogenicity pathology protective effect remained resolved RNA SARS-CoV-2 SARS-COV-2 infection serological response severe disease severity the disease the SARS-CoV-2 therapeutic strategy understanding undetectable Viral Viral RNA virus [DOI] 10.1099/jgv.0.001567 PMC 바로가기 [Article Type] Article
Assessment of SARS-CoV-2 infectivity of upper respiratory specimens from COVID-19 patients by virus isolation using VeroE6/TMPRSS2 cellsVeroE6/TMPRSS2 세포를 이용한 바이러스 분리에 의한 COVID-19 환자의 상부 호흡기 표본의 SARS-CoV-2 감염성 평가Article Published on 2021-02-012022-09-11 Journal: BMJ Open Respiratory Research [Category] 치료기술, [키워드] assessment blind blind passage Cell Cell culture cell line cells Combination correlation COVID-19 COVID-19 patient Ct values cycle threshold demonstration determined by diagnostics Human in vitro infectiousness inoculated inoculation investigated Isolation Japan Laboratory no risk Novel coronavirus outbreak Patient potential risk predicted protocol provide real-time RT-PCR respiratory respiratory infectious disease respiratory specimen respiratory specimens rRT-PCR SARS-CoV-2 SARS-CoV-2 transmission specimen specimens Spread susceptible the SARS-CoV-2 upper respiratory Viral viral infection Viral load virus virus isolation [DOI] 10.1136/bmjresp-2020-000830 PMC 바로가기 [Article Type] Article
Optimising Vaccine Dose in Inoculation against SARS-CoV-2, a Multi-Factor Optimisation Modelling Study to Maximise Vaccine Safety and EfficacyArticle Published on 2021-01-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy Ad5 adenovirus-vectored vaccines adverse event calibrated can be used COVID-19 Critical Developing dose dose dynamics dose-dependent Dose-response Dosing Efficacy and safety estimates exceeded global pandemic identify Immunity IMPROVE in viral induce inoculation less optimal dose Optimising Particle recombinant adenovirus required Research Result Safety SARS-CoV-2 SARS-CoV-2 vaccine Seroconversion statistical model Vaccine viral particle Viral particles [DOI] 10.3390/vaccines9020078 PMC 바로가기 [Article Type] Article
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 MiceK18-hACE2 마우스에서 SARS-CoV-2의 비강내 접종 후 신경 침범 및 뇌염Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Brain brains Cell cell death Central nervous system characterized chemokines CNS Coronavirus-2 correlated COVID-19 cytokine Cytokines declined direct infection Encephalitis exhibited hACE2 hallmark hemorrhage highest humans infect cell Infection Infectious virus Inflammatory response inoculation intranasal K18-hACE2 K18-hACE2 mice leukocyte leukocyte infiltration lung Lungs mice Mortality nasal nasal turbinate Neuroinflammation neuroinvasion Neurological disease neuronal olfactory olfactory bulb Onset Pathogenesis pathogenesis of SARS-CoV-2 plaque-forming unit plaque-forming units respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease Viral virus titer virus titers [DOI] 10.3390/v13010132 PMC 바로가기 [Article Type] Article
K18-hACE2 mice develop respiratory disease resembling severe COVID-19K18-hACE2 쥐, 심각한 COVID-19와 유사한 호흡기 질환 발병Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Asymptomatic Author both groups Brain cerebral cortex chemokines clinical manifestation Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis cytokeratin 18 promoter develop disease disease course disease manifestation dose-dependent DPI etiological agent expressing Extrapulmonary hACE2 hippocampus Human human SARS-CoV-2 humanized immunological disease immunological diseases in both group Infection infectious virus titer inoculated inoculation interstitial pneumonia intestinal tract K18 K18-hACE2 mice lethal disease low dose Lower respiratory tract lung Lungs lymphocyte lymphocyte infiltration Macrophage mice Mild mild to moderate moderate disease nasal turbinates Pathogenesis pathology patients Pneumocytes post inoculation progression proinflammatory Pulmonary pathology rapid inflammatory response receptor replication of SARS-CoV-2 reported respiratory Respiratory disease respiratory tract infection resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe case severe cases severe COVID-19 subset Support survival susceptible TCID Th1 Th1 and proinflammatory cytokines/chemokines the SARS-CoV-2 These data Trachea transgenic mice upper and lower respiratory tract upper and lower respiratory tract infection upregulation Viral Viral RNA shedding virus replication virus titers weight loss while [DOI] 10.1371/journal.ppat.1009195 PMC 바로가기 [Article Type] Research Article
Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental FactorsSARS-CoV-2의 전파: 바이러스, 숙주 및 환경 요인 검토Review Published on 2021-01-012022-09-11 Journal: Annals of internal medicine [Category] Fulltext, SARS, 치료기술, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus aerosol Aerosols Cluster Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Decline declines detect determinant direct contact dominant etiologic agent Evidence excluded Factor fomite help heterogeneous indicate infectiousness inoculation knowledge Live virus misinformation MOST Patient reduce respiratory review risk SARS-CoV-2 secondary case severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread Strong Support Symptom symptom onset Topic Transmission transmission cluster transmission clusters transmission of SARS-CoV-2 Ventilation Viral Viral RNA virus [DOI] 10.7326/M20-5008 PMC 바로가기 [Article Type] Review
Camelid Inoculation with Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host InfectionReview Published on 2020-11-302022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, [키워드] Animal coronaviruses Betacoronavirus camelid coronavirus coronavirus pathogenesis Critical disease event events humans Infection inoculation Intervention MERS-CoV Middle East mitigate Model outbreak Pathogenesis public health recommendation reservoir respiratory severe respiratory disease Transmission Vaccine zoonotic Zoonotic coronavirus zoonotic spillover [DOI] 10.3390/v12121370 PMC 바로가기 [Article Type] Review