PI3K in T Cell Adhesion and TraffickingReview Published on 2021-08-062023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] adhesion CCR7 CD62L integrin LFA-1 PI3K Trafficking [DOI] 10.3389/fimmu.2021.708908 PMC 바로가기 [Article Type] Review
CD49d marks Th1 and Tfh-like antigen-specific CD4+ T cells during Plasmodium chabaudi infectionArticle Published on 2021-07-232024-08-28 Journal: International Immunology [Category] 말라리아, [키워드] integrin malaria
Integrins: An Important Link between Angiogenesis, Inflammation and Eye DiseasesReview Published on 2021-07-062022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] Adhesion Molecule age macular degeneration Angiogenesis Apoptosis biological activities Cataract Cell cell proliferation cells clinically Cornea coronavirus Cytokine activation Diabetic retinopathy Diseases disorders Dry eye disease ECM Evidence Extracellular matrix eye Glaucoma high myopia Infection Inflammation integrin Integrins involved Ligand membrane-bound proteins Migration ocular receptor Research responsible Retina retinopathy of prematurity SARS-CoV-2 Signal transduction therapeutic target tissue homeostasis tissue repair Treatment viruses [DOI] 10.3390/cells10071703 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial CellsArticle Published on 2021-07-032022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] absence ACE2 expression acute lung injury acute respiratory distress analyses Analysis Angiogenesis angiogenic response antiviral molecule ARDS conditioned COVID-19 Cytopathic effect detectable early phase Endothelial cell endothelial cell dysfunction expression Human Hypothesis identify immunofluorescence assay infect Infection Inflammation Inflammatory inhibit integrin Intussusceptive angiogenesis life-threatening lung manifestation Microarray microenvironment MX1 Particles pathogenic mechanism phenotype plethora potential therapeutic target pro-inflammatory proteome Respiratory complications SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection stimulated Support syndrome vascular dysfunction vascular leakage viral infection [DOI] 10.3390/microorganisms9071438 PMC 바로가기 [Article Type] Article
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation [DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article
ELV-N32 and RvD6 isomer decrease pro-inflammatory cytokines, senescence programming, ACE2 and SARS-CoV-2-spike protein RBD binding in injured corneaArticle Published on 2021-06-172022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome affecting angiotensin-converting enzyme 2 binding Bioactivity cause contribute Corneal coronavirus coronavirus disease COVID-19 Culture cytokine damaged decrease Drug discovery epithelial cell expression furin hyper-inflammation IFNγ in vivo Infection Inflammation integrin lipid mediator mitigate pandemic pro-inflammatory cytokines programming Protein public health crisis RBD RBD binding Resolvin RNA-seq analysis SARS-CoV-2 spike the receptor-binding domain therapeutic Treatment triggering viral infection virus [DOI] 10.1038/s41598-021-92293-x PMC 바로가기 [Article Type] Article
α V β 6 Integrin: An Intriguing Target for COVID‐19 and Related DiseasesViewpoint Published on 2021-06-152022-10-31 Journal: Chembiochem [Category] COVID-19, MERS, SARS, [키워드] αVβ6 Affect COVID-19 COVID‐19 disease Evidence fibrosis health emergency integrin Novel coronavirus outbreak pandemic pharmacological recovered patients RGD SARS-CoV-2 SARS‐CoV‐2 sequence Spread target the spike protein therapeutic agent [DOI] 10.1002/cbic.202100209 PMC 바로가기 [Article Type] Viewpoint
Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein–Protein Docking, Molecular Dynamics, and MM-GBSA CalculationsArticle Published on 2021-05-272022-10-29 Journal: Journal of Chemical Information and Modeling [Category] COVID-19, MERS, SARS, [키워드] accessory proteins Adhesion Molecule Antigen Area binding calculation complex contribute coronavirus 2 docking Dynamics enrolled Genome Immunoglobulin insight integrin involved lymphocyte macromolecular molecular Open reading frame ORFs pathogenicity reported respiratory SARS-CoV SARS-CoV-2 surface [DOI] 10.1021/acs.jcim.1c00198 PMC 바로가기 [Article Type] Article
Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19Gut Homing Marker α4β7 Integrin을 발현하는 순환 적응 면역 세포는 COVID-19에서 감소합니다Immunology Published on 2021-04-202022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive B cell cause characterized circulating contribute convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Decreased epithelial cells expressing expression flow cytometry Frequency Gastrointestinal symptom gastrointestinal symptoms Gut gut homing healthy control healthy controls homing IgA IgA-expressing Immune cell immune cells immune responses immune system integrin Integrins intestinal intestinal epithelial cell intestinal epithelial cells Lymphocytes Manifestations marker memory T Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes priming recruited respiratory Result SARS-CoV-2 SARS-COV-2 infection Symptom systemic immune response systemic immune responses T cell trafficking target these cell These cells tissue virus was reduced while wide range of symptoms [DOI] 10.3389/fimmu.2021.639329 PMC 바로가기 [Article Type] Immunology
The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial CellsArticle Published on 2021-04-092022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome alveolar epithelial cell alveolar epithelial cells angiotensin-converting enzyme 2 bind Cell adhesion cellular coronavirus entry receptor epithelial cells experimental evidence expressed in silico infect integrin Interaction Ligand predicted pulmonary epithelial cell receptor recognize SARS-CoV-2 sequence spike spike 1 protein spike glycoprotein Spike protein subset Support surface the spike protein viral infection viral infections [DOI] 10.3390/v13040645 PMC 바로가기 [Article Type] Article