Dynamics in COVID-19 symptoms during different waves of the pandemic among children infected with SARS-CoV-2 in the ambulatory setting보행 환경에서 SARS-CoV-2에 감염된 어린이들 사이에서 전염병의 다양한 파도 동안 COVID-19 증상의 역학Article Published on 2022-09-012022-09-11 Journal: European journal of pediatrics [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age all age groups Alpha alpha and delta variants Alpha variant Analysis Chain Reaction Characteristics children Cohort coronavirus Coronavirus-2 COVID-19 severity COVID-19 symptom Delta delta variant Dynamics evaluate febrile illness Fever Final final analysis groups health maintenance Health Maintenance Organization hospital infected children infected with SARS-CoV-2 lowest maintenance occurred organization pandemic Patient paucity of data polymerase chain polymerase chain reaction positive Preschool Prevalence reported RT-PCR SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher Symptom symptomatic symptomatic disease Symptoms variant variants Waves [DOI] 10.1007/s00431-022-04531-7 PMC 바로가기 [Article Type] Article
Distinct type I interferon responses between younger women and older men contribute to the variability of COVID-19 outcomes: Hypothesis generating insights from COVID-19 convalescent individuals젊은 여성과 나이든 남성 사이의 뚜렷한 유형 I 인터페론 반응은 COVID-19 결과의 가변성에 기여합니다: COVID-19 회복기 개인으로부터 통찰력을 생성하는 가설Article Published on 2022-09-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] age Analysis blood type C-reactive protein calculated Clinical outcome contribute convalescent convalescent individual convalescent individuals COVID-19 COVID-19 infected patients determined by ELISA epidemiological studies exhibited female females groups healthy individual highest Hospitalization hospitalized patients Ifi44 IFN IFN-inducible gene IFN-inducible genes IL-6 IL-6 level Inclusion infected patients interleukin less lowest male Male sex males median men Mortality Older opposite outcome PCR Peripheral blood population groups premenopausal female quantified real time real time PCR response SARS-CoV-2 serum Serum level serum levels Sex shown significantly significantly higher significantly increased Stratification Type type I Type I IFN type I interferon type I interferon (IFN). Variability was performed women [DOI] 10.1016/j.cyto.2022.155964 PMC 바로가기 [Article Type] Article
A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies혈액암이 있는 성인 환자의 SARS-CoV-2 백신 1차 및 2차 접종에 대한 면역 반응의 체계적인 검토 및 메타 분석Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval 95%CI affected affecting anti-CD20 therapy antibody Antibody detection Antibody Response article booster dose booster doses calculated Cancer patients chronic lymphocytic leukemia CLL Complete conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop Diagnosis disease doses evaluate first dose Google Google Scholar healthy subject healthy subjects Hematological malignancies Hematological malignancy higher risk highlight highlighting immune response Immunity immunization Immunocompromised immunogenicity immunosuppressive IMPROVE kinase inhibitors less leukemia lowest Lymphocytic leukemia lymphoma malignancy measure Meta-analysis mRNA mRNA-1273 Myeloma Patient Primary outcome response rate SARS-CoV-2 SARS-CoV-2 vaccine second dose secondary outcome Secondary outcomes seropositive Seropositivity severe coronavirus disease solid tumor solid tumors status subgroup subtype systematic review the disease the vaccine tumors tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Vaccine vaccine dose vaccine's immunogenicity Web of Science [DOI] 10.1016/j.intimp.2022.109046 PMC 바로가기 [Article Type] Review
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
Effectiveness of 2 Pretreatment Methods in Antifogging of Goggles in a COVID-19 Isolation Ward: A Randomized Controlled TrialResearch article Published on 2022-09-012022-10-05 Journal: Journal of emergency nursing [Category] 임상, [키워드] 1:1 Anti-fogging Antibacterial hand sanitizer coated with control group Controlled COVID-19 Effectiveness Efficiency evaluated eyes Goggle Goggles Health care worker health care workers impacted Iodophor solution less lowest Nurse participant reduce reported Result significantly Transmission treated [DOI] 10.1016/j.jen.2022.06.004 [Article Type] Research article
In silico prediction of SARS-CoV-2 main protease and polymerase inhibitors: 3D-Pharmacophore modellingSARS-CoV-2 주요 프로테아제 및 폴리머라제 억제제의 인 실리코 예측: 3D-Pharmacophore 모델링Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CLpro active site acute respiratory syndrome acute respiratory syndrome coronavirus addition affinity applied approach approved Atazanavir AutoDock binding affinity binding pocket candidate caused chymotrypsin coronavirus COVID-19 determine docking docking study drug effective enzyme hepatitis C hepatitis C virus HIV protease inhibitor identify in silico inhibitors inspiration lowest methodology outbreak overcome pandemic pharmacophore modelling polymerase predict Prevent protease protease 3Clpro. protocol RdRP RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease social distancing stable complex Structure structures suggested Tegobuvir tipranavir Transmission Treatment Vaccine virus [DOI] 10.1080/07391102.2021.1886991 PMC 바로가기 [Article Type] Article
Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assaysArticle Published on 2022-09-012022-11-15 Journal: Mathematical biosciences [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Analysis antibody approach approaches average Bathtub-type principle classification diagnostic effective expressed identify Inconclusive labeling less Local lowest multiplex Probability reduction in Saliva SARS-CoV-2 SARS-CoV-2 antibody threshold [DOI] 10.1016/j.mbs.2022.108858 PMC 바로가기
Trends in the Use of Face Coverings in Publicly Accessible Spaces During the COVID-19 Pandemic, King County, Washington, November 2020-May 2021COVID-19 팬데믹 기간 동안 공개적으로 접근 가능한 공간에서 안면 가리개 사용 추세, 워싱턴 주 킹 카운티, 2020년 11월-2021년 5월Observational Study Published on 2022-09-012022-09-11 Journal: Public health reports (Washington, D.C. : 1974) [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 95% CI 95% CIs absence age airport Appropriate calculated Compliance conducted Covering COVID-19 cross-sectional declined estimate evaluate Evaluation face face covering Face mask face mask mandate. group help International airport interval King lowest men mitigate not limited observation observational study prevalence ratio prevalence ratios recorded repeated SARS-CoV-2 SARS-CoV-2 transmission Sex Space transmission of SARS-CoV-2 trend unique vaccination vaccine eligibility viral variant Viral variants Washington widespread [DOI] 10.1177/00333549221100795 PMC 바로가기 [Article Type] Observational Study
Detecting Waning Serological Response with Commercial Immunoassays: 18-Month Longitudinal Follow-up of Anti-SARS-CoV-2 Nucleocapsid AntibodiesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Abbott Accuracy acute respiratory syndrome adjusted Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 immune response antibodies antibody Antibody concentrations Antibody detection Architect cohorts commercial immunoassay conducted convalescent individual coronavirus coronavirus disease COVID-19 cumulative dependent on Detection limit Elecsy ELISA enzyme-linked immunosorbent evaluated Follow-up Health care worker heterogenous highest IgG immune responses immunoassay immunoassays incidence individual Infection longitudinal lowest nucleocapsid protein Patient Reinfection response Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections selected serological serological kinetics serum serum antibody Surveillance tested the SARS-CoV-2 threshold unique waning antibody. [DOI] 10.1128/spectrum.00986-22 PMC 바로가기
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA ThresholdsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody assay standardization assays authorization can be used CCP clinical trials Clinical use Cohort collected comparable Concordance consequence convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma criteria Cutoff cutoff value Donor drug Emergency Emergency use authorization EUA Expanded Access Program FDA FDA EUA FIVE food high-titer CCP high-titer convalescent plasma highlight hospitalized patients identification identify immunosuppressed patients indicate Limited lowest monoclonal antibody multiple serological assay Pandemics Pathogens positive precluded provided ranged reduce released Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic serologic assay serological Serological assay serological assays serology serum sample significantly Standardization therapeutic therapeutic option therapy threshold Treatment [DOI] 10.1128/spectrum.01154-22 PMC 바로가기