The pigtail macaque ( Macaca nemestrina ) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of diseaseCOVID-19의 돼지꼬리원숭이(Macaca nemestrina) 모델은 다양한 임상 결과를 재현하고 질병의 새롭고 복잡한 징후를 나타냅니다.Research Article Published on 2021-12-202022-09-10 Journal: PLoS Pathogens [Category] 변종, 진단, [키워드] animal animal model animal models approach Blood Cardiovascular Symptoms causative agent CD4+ CD4+ T cell CD4+ T cells CD8 claimed Clinical outcome Coagulation Cohort complex COVID-19 COVID-19 disease COVID-19 pandemic Critical disease drug Effective vaccines euthanized exhibited Express feature FIVE human disease humans immune Increases increases in Infection infection with SARS-CoV-2 Inflammatory lesions less macaque manifestation marker mechanism Mild-to-moderate Neutralizing antibodies Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis pathologic Pigtail pulmonary pulmonary infiltrates respiratory respiratory viral reveal rising SARS-COV-2 infection SARS-CoV-2 viral severe COVID-19 disease severe disease severe disease course simian immunodeficiency virus SIV span Symptom T cell T cells tested Therapeutics transmissible variant transmissible variants treat Vaccine Viral viral dynamics viruses with infections [DOI] 10.1371/journal.ppat.1010162 PMC 바로가기 [Article Type] Research Article
Germinal Center-Induced Immunity Is Correlated With Protection Against SARS-CoV-2 Reinfection But Not Lung Damage생식기 센터 유도 면역은 SARS-CoV-2 재감염에 대한 보호와 상관관계가 있지만 폐 손상은 아닙니다Article Published on 2021-12-012022-09-12 Journal: The Journal of Infectious Diseases [Category] 진단, [키워드] acute respiratory syndrome Against alleviate antibody-secreting cell clade Combination coronavirus coronavirus disease COVID-19 damage Diagnosis Diffuse alveolar damage elicit gcs Germinal Germinal center highlight humans immune responses IMPROVE Infection lung lung damage macaque macaques memory B cells pathogen invasion protection protective humoral immunity protective immunity reduction in Reinfection replicating virus respiratory tract resulting SARS-CoV-2 SARS-COV-2 infection Seroconversion subsequent infections tissue Treatment vaccination Vaccine development Viral load viral reinfection. virus [DOI] 10.1093/infdis/jiab535 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma인간 COVID-19 회복기 혈장으로 조기에 치료된 붉은털 원숭이의 SARS-CoV-2 감염Research Article Published on 2021-11-242022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered administration animal models of infectious diseases benefit Blood blood clotting clinical disease Clinical studies clinical study collected contribute Control convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease early infection Efficacy Endpoint had no Human Human plasma immune pressure immunization Immunotherapy IMPROVE in vivo include Infection Inflammation information Interpretation lung macaque macaques mechanism medium microbial pathogenesis nasal Neutralizing antibodies neutralizing antibody nonhuman primate normal human plasma normalization not reduce pandemic Pandemics passive immunization plasma produced provided question receiving reduce respiratory SARS-CoV-2 SARS-COV-2 infection secretion sequence severe acute respiratory syndrome Coronavirus symptom onset tested therapeutic Treatment Vaccine variant Viral viral loads viral shedding viral variant Virology Virus neutralization [DOI] 10.1128/Spectrum.01397-21 PMC 바로가기 [Article Type] Research Article
Evaluation of the Relationship between Clonal Hematopoiesis and Severe COVID-19 Disease in Rhesus MacaquesConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] Acquired advanced age age Analysis Asymptomatic autologous Autopsy BAL benefit Blood clinical manifestation clinical symptom clinically co-morbidities cohort study Concentration Control control group controls COVID-19 COVID-19 disease detectable develop died disease Evidence expand Factor Genes group hallmark Hematopoiesis Human Hyperinflammatory IL-6 IL-6 level IL-8 Infection Inflammation inoculated Laboratory LOF loss of function lung tissue macaque MCP-1 Mild MIP-1b Multiorgan mutant Mutation occur pathophysiological pathophysiology phenotype progenitor cell relationship reported Respiratory failure Respiratory samples rhesus macaque risk risk factor robust Sample size SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sera severe COVID-19 severe COVID-19 disease severe COVID-19 illness significant difference somatic mutation suggested Symptom TET2 the median therapeutic approaches therapy Vaccine development Viral antigen [DOI] 10.1182/blood-2021-152628 [Article Type] Conference abstract
Cross-reactive antibodies after SARS-CoV-2 infection and vaccinationSARS-CoV-2 감염 및 예방접종 후 교차 반응 항체Research Article Published on 2021-11-232022-10-31 Journal: eLife [Category] COVID-19, SARS, 파상풍, [키워드] addition antibodies antibodies binding antibody convalescent sera coronavirus COVID-19 cross-reactive antibody cross-reactivity current Efficacy feasibility Guidance HCoV healthy donors Human human coronavirus humans increase in investigated macaque MERS-CoV Novel coronavirus Other Outbreaks PROTECT protective vaccines Protein response S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine specificity Support the S protein vaccination Vaccine variant [DOI] 10.7554/eLife.70330 PMC 바로가기 [Article Type] Research Article
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody LeronlimabCCR5 수용체 점유 분석 결과 항-CCR5 항체 레론리맙 치료 후 말초혈액 CCR5+CD4+ T 세포 증가Clinical Trial Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] antibody assays binding blockade Blood cancer progression CCR5 CD4 CD4+ T cell CD4+ T cells Cell circulating comparable Complete correlated Critical Defense Efficacy facilitate flow cytometric flow cytometry HIV Host Human humans immunological Impact in vivo increase in Increased independent Infectious disease lack macaque macaques Occupancy pathophysiological peripheral Peripheral blood plasma plasma concentration Receptor occupancy receptor occupancy (RO) resulting sensitivity statistically significant suppressed T cell therapeutic Treatment viral replication Viremia Weekly with HIV [DOI] 10.3389/fimmu.2021.794638 PMC 바로가기 [Article Type] Clinical Trial
Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies2개의 비경구 투여 SARS-CoV-2 중화 항체의 조합을 사용하여 붉은털 원숭이에서 COVID-19의 효과적인 예방Cellular and Infection Microbiology Published on 2021-11-182022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] accelerate added Administered administration anti-SARS-CoV-2 antibody combination benefit beta coronavirus block blocking clinical study Cohort Combination combination treatment Complete COVID-19 disease dose effective evidenced immunoprophylaxis Infection lack lower dose mAb macaque monoclonal antibody mucosal neutralize nonhuman primates parenteral administration pathogenic pathologic pathology pharmacokinetics prophylactically Protective receiving Result rhesus SARS-CoV-2 SARS-CoV-2 antibodies subset swabs tissue viral challenge viral infection virus Virus neutralization worldwide pandemic [DOI] 10.3389/fcimb.2021.753444 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaquesMathematics Published on 2021-11-172022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Adults Ageing Antiviral treatment averaged cause caused COVID-19 cynomolgus macaque death estimate estimation in viral individuals Infection macaque mathematical model nasal passages nose and throat Older older patients parameter Parameter estimation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus titre viral kinetics virus [DOI] 10.1098/rsos.202345 PMC 바로가기 [Article Type] Mathematics
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화Article Published on 2021-11-102022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type [DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article
Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques붉은 털 원숭이의 비강 및 기관 내 SARS-CoV-2 감염에 대한 위장 SARS-CoV-2 전달의 보호 효능Vaccines and Antiviral Agents Published on 2021-10-272022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus administration Antibody titer Bronchoalveolar lavage fluid challenge conducted coronavirus correlated Coverage COVID-19 delivery distribution Efficacy esophagogastroduodenoscopy Formulation Gastrointestinal gastrointestinal tract greater health benefits immunogenic immunogenicity intranasal intratracheal live oral vaccine Live oral vaccines live SARS-CoV-2 macaque mucosal nasal swab nasal swabs offer oral administration Oral vaccine Prophylactic Protective protective efficacy public health Rectal swabs respiratory viruses rhesus macaque rhesus macaques route SARS-CoV-2 serotype Serum neutralizing antibody severe acute respiratory syndrome Coronavirus timelines Vaccine Vaccines Viral load virus replication [DOI] 10.1128/JVI.01599-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents