Development of a quantitative COVID-19 multiplex assay and its use for serological surveillance in a low SARS-CoV-2 incidence community정량적 코비드 -19 멀티 플렉스 분석의 개발 및 낮은 SARS-COV-2 발병 커뮤니티에서 혈청 감시에 대한 사용Research Article Published on 2022-01-212022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, 치료법, [키워드] anti-RBD antigens AUC can be used Cohort collected Community controls convalescent patient Convalescent patients correlated correlation COVID-19 COVID-19 PCR test detection development domain dynamic range evaluated Exposure Rate expressed expression greater healthy volunteer healthy volunteers identify IgA IgG IgM immune response incidence incidence rate Infection initial Ithaca mammalian moderate Multiplex assay Neutralization assay nucleocapsid protein pandemic Patient PCR test performed positive result Quantitative quantitative assay RBD RBD antigen RBD protein RBD proteins Receptor-binding domain Sample SARS-CoV-2 SARS-CoV-2 virus selected serological serological surveillance Serological testing Seroprevalence serum serum sample serum samples Spike protein the SARS-CoV-2 the spike protein vaccination Volunteer [DOI] 10.1371/journal.pone.0262868 PMC 바로가기 [Article Type] Research Article
Covalent coupling of Spike’s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2스파이크의 수용체 결합 도메인의 다층 담체에 대한 공유 커플 링은 SARS-COV-2에 대해 높은 면역 반응을 생성한다.Article Published on 2022-01-132022-09-01 Journal: Scientific Reports [Category] 진단, [키워드] Antigen presentation average Biochemistry Brucella candidate Candidates composed COVID-19 vaccine develop dose effective elicited expressed HEK-293T cells humoral immune response IgGs immune response immune system immunogenic immunology induce mammalian mice Neutralizing Neutralizing antibodies Particle Pichia pastoris produced Protein RBD Receptor binding domain reported SARS-CoV-2 significantly higher Spike protein Synthase the Spike vaccinate Vaccine were used [DOI] 10.1038/s41598-021-03675-0 PMC 바로가기 [Article Type] Article
Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression SystemsArticle Published on 2022-01-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis Antibody titer antigenic BALB/c mice cells CHO cell Comparative COVID-19 domain effective ELISA expressed expression humoral immune response immunized immunogenic immunogenicity maintain mammalian mice neutralization neutralizing antibody Protein protein S provide RBD Receptor-binding domain recombinant recombinant RBD protein S protein SARS-CoV-2 sera significantly subunit vaccines System target target protein the RBD Vaccine variant [DOI] 10.3390/vaccines10010096 PMC 바로가기 [Article Type] Article
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 보호를 제공하는 장내 미생물총 유래 대사산물Article Published on 2022-01-012022-09-11 Journal: Gut Microbes [Category] SARS, 치료제, [키워드] ACE2 adaptive Adaptive immunity airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-viral immunity antiviral immunity characterized Coagulation coronavirus disease Coronavirus disease 2019 COVID-19 downregulating entry receptor enzyme fatal COVID-19 Fatty acid fiber function Gut gut bacteria gut microbiome Host Hypercoagulation identify immune regulation Immunity Infection intestine intestines intranasal male males mammalian metabolism metabolite Microbiome multiple pathway multiple pathways Platelet proliferation promote PROTECT reduced SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SCFA SCFAs Sh2b3 short-chain fatty acids systemically the SARS-CoV-2 viral burden viral entry [DOI] 10.1080/19490976.2022.2105609 PMC 바로가기 [Article Type] Article
Rosin Soap Exhibits Virucidal ActivityResearch Article Published on 2021-12-222022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome Affect antimicrobial Antiviral Chemical Concentration Contamination Control coronavirus coronavirus disease COVID-19 death dependent on derivative Evidence fomite Health help hospitals human disease hygiene IAV in vitro inactivation Infection influenza A virus Influenza virus inhibitory effect mammalian mitigate pandemic pathogenic Prevent produced reduction in Resin respiratory syncytial virus Rosin SARS-CoV-2 shown soap Spread temperature Viral transmission virucidal virus virus inactivation virus infection viruses [DOI] 10.1128/spectrum.01091-21 PMC 바로가기 [Article Type] Research Article
Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2Short Reports Published on 2021-12-212022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] ACE2 acting alteration amino acid substitution binding cardiovascular system cellular Combination coronavirus 2 decrease Deleterious deleterious effect enzyme event Evolution extreme function Genetic host range Human human ACE2 identify implicated in viral in vivo infect Infection mammalian Mutation ortholog pandemic pathogenic pathway physiological polymorphism predicted required respiratory S protein SARS-CoV-2 SARS-CoV-2 susceptibility sequence Substitution susceptible the SARS-CoV-2 unique variant virus [DOI] 10.1371/journal.pbio.3001510 PMC 바로가기 [Article Type] Short Reports
Understanding the outcomes of COVID-19 – does the current model of an acute respiratory infection really fit?COVID-19의 결과 이해 – 현재의 급성 호흡기 감염 모델이 정말 적합합니까?Insight Review Published on 2021-12-172022-09-12 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, [키워드] Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody appearance assumption attribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease severity Effect Epidemic Evidence example followed by hepatitis C hepatitis C virus host immune responses immune responses increasingly individual Infection Influenza influenza A influenza A virus instance lack literature review mammalian Neutralizing antibodies occur outcome pathogenic PCR positivity persistence Prolonged proportion protective immunity Reinfection respiratory syncytial virus respiratory syncytial virus influenza A virus respiratory viruses RNA RNA genome RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus understanding virus clearance virus-neutralizing antibodies [DOI] 10.1099/jgv.0.001545 PMC 바로가기 [Article Type] Insight Review
Molecular Characterization of Infectious Bronchitis Virus Strain HH06 Isolated in a Poultry Farm in Northeastern ChinaVeterinary Science Published on 2021-12-162022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] Analysis bovine characterization characterized China clade clades coronavirus Coronaviruses CoV CoVs domain Epidemic Evolution explain farm Genetic Genome glycoprotein HCoV-OC43 Host IBV indicated Infectious Bronchitis Virus Isolated maintain mammalian MERS-CoV Molecular epidemiology motif Phylogenetic Phylogenetic relationship poultry protein sequence Recombination S gene S protein SARS CoV-2 SARS-CoV SARS-CoV-2 selected selection pressure sequence spike Spread strain variant virulent viruses zoonosis [DOI] 10.3389/fvets.2021.794228 PMC 바로가기 [Article Type] Veterinary Science
ACE and ACE2: insights from Drosophila and implications for COVID-19Review article Published on 2021-12-072022-10-05 Journal: Heliyon [Category] 변종, [키워드] accelerated ACE ACE2 Acer acute respiratory syndrome addition Ance Biochemistry Cardiovascular function catalytically cellular entry conserved coronavirus coronavirus disease COVID-19 COVID-19 pandemic Drosophila Drosophila melanogaster enzyme function functional highlight homologue homology identify implication in vivo knowledge mammalian organism orthologue pathogenicity peptides provide raise recent receptor renin-angiotensin system Research responsible SARS-CoV-2 therapeutic intervention unique utility Vaccine variants various coronaviruses Vasoactive Virus-host interaction [DOI] 10.1016/j.heliyon.2021.e08555 [Article Type] Review article
Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System누에-배큘로바이러스 발현 시스템을 이용한 SARS-CoV-2에 대한 CR3022 항체의 scFv, Fab 및 IgG 생산Article Published on 2021-12-012022-09-11 Journal: Molecular biotechnology [Category] SARS, 유전자 메커니즘, 진단, [키워드] affinity Against antibody caused COVID-19 CR3022 CR3022 antibody diagnostic diagnostic agents Emerging infectious diseases expression expression vector Fab IgG IgG antibodies IgG antibody Infectious disease Infectious diseases mammalian monoclonal antibody produced Production RBD Receptor binding domain Research S protein SAME AS SARS patients SARS-CoV SARS-CoV-2 scFv shown Silkworm-baculovirus expression vector system spike Spike protein SPR System the spike protein therapeutic agents Viral [DOI] 10.1007/s12033-021-00373-0 PMC 바로가기 [Article Type] Article