Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (M pro )Article Published on 2020-06-292022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome anti-SARS-CoV-2 applied binding affinity binding free energy binding mode calculate complexes Compound compounds coronavirus COVID-19 disease docking drug candidates experiment filtered Final inhibitor Interaction M pro MPro MDs microbial microbial natural products molecular molecular dynamic simulation natural performed Potential product protease provide SARS-CoV-2 structural flexibility structure-based design table Virtual screening [DOI] 10.3390/microorganisms8070970 PMC 바로가기 [Article Type] Article
Deep sequencing of HBV pre-S region reveals high heterogeneity of HBV genotypes and associations of word pattern frequencies with HCCHBV pre-S 영역의 심층 시퀀싱은 HBV 유전자형의 높은 이질성과 HCC와 단어 패턴 빈도의 연관성을 보여줍니다Research Article Published on 2018-02-232022-09-06 Journal: PLoS Genetics [Category] B형 간염, Communicable Disease, [키워드] Accuracy Analysis approach approaches association AUC build calculated can be used characteristic CHB China Classifier Clustering Complication Cross-validation data set deep followed by fraction Frequency Genotype group HBV HBV infection HCC HCC patient hepatitis B Hepatitis B virus Hepatocellular carcinoma heterogeneity Hierarchical hierarchical clustering high accuracy High-throughput sequencing include independent data set individual individuals infected individual infected individuals Infection information lead liver Liver cancer Manhattan distance MDs next generation sequencing NGS predict prevalent Probability regions reveal Sanger sequencing second sequence sequences Sequencing shown significantly Support support vector machine SVM virus was obtained [DOI] 10.1371/journal.pgen.1007206 PMC 바로가기 [Article Type] Research Article