The Considerations and Controversies in Using High-Flow Nasal Oxygen with Self-Prone Positioning in SARS-CoV-2 COVID-19 DiseaseCase Report Published on 2021-05-242022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] clinical trial COVID-19 Critical care Evidence female HFNO High-flow nasal oxygen hospital Hypoxemia hypoxemic implication intubation management mechanical ventilator noninvasive oxygen parameter Patient patients positioning Respiratory failure response risk SARS-CoV-2 [DOI] 10.1155/2021/5541298 PMC 바로가기 [Article Type] Case Report
The repurposed use of anesthesia machines to ventilate critically ill patients with coronavirus disease 2019 (COVID-19)Research Published on 2021-05-202022-10-28 Journal: BMC Anesthesiology [Category] COVID-19, [키워드] adjusted allocation Analysis analyzed Anesthesia Anesthesia machine ARDS assigned Care clinical Cohort comparable Complication conducted coronavirus coronavirus disease covariate COVID-19 COVID-19 diagnosis COVID-19 patient Critical care Critically ill patient determine Follow-up hospital Hypothesis ICU intensity intensive care unit Italy machine mechanical ventilation mechanical ventilator mechanical ventilators mechanically ventilated patient Mortality multivariable Cox regression non-survivor not applicable Operating room outcome pandemic Patient patients with COVID-19 raising receiving reported Respiratory failure Result Retrospective study risk risk factor risk of death severely ill patient severity significantly higher significantly increased supplementary material Support survivor treat treated Treatment Trial two groups were assessed [DOI] 10.1186/s12871-021-01376-9 PMC 바로가기 [Article Type] Research
Clinical and Radiological Profiles of COVID-19 Patients with Neurological Symptomatology: A Comparative Study신경학적 증상이 있는 COVID-19 환자의 임상 및 방사선 프로파일: 비교 연구Comparative Study Published on 2021-05-062022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] Admission Analysis Arterial hypertension association bleeding Brain brain MRI brain scan Cerebral artery Chest CT chronic renal failure clinical Comparative COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients CT diffusion enhancement epidemiological evaluated Facial nerve facial nerve palsy Factor ganglia greater hypertension ICU identify irregularity Ischemic Stroke lesions Lung disease lung injuries mechanical ventilator middle cerebral artery MRI Neuroimaging Neurological involvement olfactory bulb olfactory bulbs palsy patients with COVID-19 predictor profile radiological radiology renal renal failure Retrospective study Risk factors Sepsis severe COVID-19 disease severity statistically significant difference stroke systemic arterial hypertension two groups undergo was performed with COVID-19 [DOI] 10.3390/v13050845 PMC 바로가기 [Article Type] Comparative Study
Importance of glutamine 189 flexibility in SARS-CoV-2 main protease: Lesson learned from in silico virtual screening of ChEMBL database and molecular dynamicsSARS-CoV-2 주요 프로테아제에서 글루타민 189 유연성의 중요성: ChEMBL 데이터베이스 및 분자 역학의 인실리코 가상 스크리닝에서 얻은 교훈Article Published on 2021-05-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 치료제, [키워드] approved caused ChEMBL ChEMBL database Clinical management complexes Compound COVID-19 database evaluated filtered finger GLN189 global pandemic Glutamine Importance in silico include infected patient infected patients infection control inhibitor inhibitory activity lesson MD simulation mechanical ventilator molecular molecular docking molecular dynamics Molecular dynamics (MD) outbreak oxygen performed pharmacological pharmacophore Pharmacophore elucidation pharmacophores plasticity protease Protein target Repurposed drug Repurposed drugs S-protein SARS-CoV-2 SARS-CoV-2 main protease social distancing supplemental oxygen Support supportive care targets the SARS-CoV-2 therapeutic efficacy training set treating COVID-19 US-FDA Virtual screening were used WHO guideline [DOI] 10.1016/j.ejps.2021.105744 PMC 바로가기 [Article Type] Article
RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19RAMIC: COVID-19 환자에서 라미프릴의 효능을 평가하기 위한 무작위, 이중 맹검, 위약 대조 시험 설계Article Published on 2021-04-012022-09-11 Journal: Contemporary clinical trials [Category] MERS, SARS, 바이오마커, 임상, [키워드] ACE Adult patients angiotensin Complication composite endpoint coronavirus disease Coronavirus disease 2019 COVID-19 death decrease diastolic double-blind Efficacy emergency department Endpoint evaluate exclusion criteria filtration rate glomerular filtration rate hospital ICU admission include Informed consent inhibitor Invasive mechanical ventilation Mechanical mechanical ventilation mechanical ventilator mitigate Mortality multicenter Novel coronavirus novel coronavirus disease occur patients with COVID-19 Personal protective equipment Placebo placebo-controlled trial PPE primary composite endpoint ramipril Randomized receive reduced risk risk risk of infection risk of transmission SARS-CoV-2 transmission SARS-CoV2 shown study population study visit Systolic blood pressure Treatment Virtual visit. [DOI] 10.1016/j.cct.2021.106330 PMC 바로가기 [Article Type] Article
Increasing the efficiency of mechanical ventilators during pandemics through additive manufacturingSpecial Article Published on 2021-04-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] 24 hour 24 hours addition Additive manufacturing collected country COVID-19 COVID-19 pandemic cross-contamination determine Efficiency equipment expand help human lung increase in Increasing mechanical ventilator mechanical ventilators MOST multiplexer Pandemics parameter Patient Peak pressure Positive end-expiratory pressure required Research Respiratory failure reveal tested Usage Ventilated Ventilation ventilator Volume [DOI] 10.17305/bjbms.2020.5165 PMC 바로가기 [Article Type] Special Article
Circulating Nucleosomes as Potential Markers to Monitor COVID-19 Disease ProgressionMolecular Biosciences Published on 2021-03-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] affected Asymptomatic Belgium Biomarker Biomarkers circulating Citrullination Cohort coronavirus disease Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 positive patient death determine disease severity Drug discovery ECMO effective elevated equipment extracorporal membrane oxygenation Germany healthy control hospital ICU immunoassay independent individual individuals liquid biopsy mechanical ventilator NETosis neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps Nucleosome plasma Potential Quantitative respiratory Respiratory failure SARS nucleosomes severity significantly subset tested the disease Treatment treatment allocation variant [DOI] 10.3389/fmolb.2021.600881 PMC 바로가기 [Article Type] Molecular Biosciences
The association of COVID-19 occurrence and severity with the use of angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers in patients with hypertensionResearch Article Published on 2021-03-182022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval ACEi adjusted Affair age angiotensin-converting enzyme inhibitor ARB association blocker CCI Charlson Comorbidity Index Clinical severity Cohort collected Comorbidities Comorbidity coronavirus disease covariates COVID-19 COVID-19 testing demographics Department determine died enzyme examined Hospitalization Hospitalized hypertension ICU Inconclusive increase in inhibitor Inpatient intensive care investigated Logistic regression mechanical ventilation mechanical ventilator mechanical ventilators medication medications Mortality multinomial logistic regression Occurrence Odds ratio outcome outpatients participant Patient patients positive positive COVID-19 receptor reported Result selected severity severity of COVID-19 Sex significantly significantly increased Sociodemographic veteran veterans warehouse Weighting [DOI] 10.1371/journal.pone.0248652 PMC 바로가기 [Article Type] Research Article
Heterogeneity in COVID-19 patient volume, characteristics and outcomes across US Department of Veterans Affairs facilities: an observational cohort studyObservational Study Published on 2021-03-082022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] accounted adult intensive & Affair age Characteristics cohort study COVID-19 COVID-19 mortality COVID-19 patient COVID-19 testing Critical Critical care Department difference Effect explained Follow-up general medicine (see internal medicine) healthcare facility Healthcare system heterogeneity Hospital admission ICU ICU patient Inpatient Intensive intensive care IQR logistic regression modelling majority mechanical ventilation mechanical ventilator median age Mortality Observational cohort study outcome Patient patients with COVID-19 populations USA Variation veteran Volume with COVID-19 [DOI] 10.1136/bmjopen-2020-044646 PMC 바로가기 [Article Type] Observational Study
Mesenchymal Stem Cell-Derived Exosomes Exhibit Promising Potential for Treating SARS-CoV-2-Infected PatientsReview Published on 2021-03-072022-10-31 Journal: Cells [Category] COVID-19, [키워드] Anti-inflammatory assist Cell clinical trial clinicians and researcher co-morbidity COVID-19 COVID-19 infection COVID-19 pandemic disease effort Exosome Exosomes Extracellular vesicles Health immunomodulatory property IMPROVE knowledge lockdown management mechanical ventilator Mesenchymal stem cells Novel coronavirus outcome pandemic patients Pneumonia Potential researchers responsible SARS-CoV-2 SARS-CoV-2-infected patients STEM stem cell therapeutic regime therapy threat treat treating treatment for COVID-19 World War II [DOI] 10.3390/cells10030587 PMC 바로가기 [Article Type] Review