Risk of COVID-19 hospital admission among children aged 5–17 years with asthma in Scotland: a national incident cohort studyArticles Published on 2022-02-012022-10-29 Journal: The Lancet. Respiratory Medicine [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI adjusted age Analysis asked association Asthma challenge children cohort study Commission Comorbidity Corticosteroid Corticosteroids Course COVID-19 dataset defined enhanced finding funding hazard ratio hospital Hospital admission hospitalisation HRs identify immunisation increased risk Industrial Infection Innovation marker Medical Research Council National outcomes risk of COVID-19 RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Scottish serious COVID-19 Sex Strategy stratified subset translate used data Vaccinations was done was used with COVID-19 [DOI] 10.1016/S2213-2600(21)00491-4 PMC 바로가기 [Article Type] Articles
Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study남아프리카 공화국에서 SARS-CoV-2 오미크론 변이체의 임상 중증도에 대한 조기 평가: 데이터 연계 연구Articles Published on 2022-01-292022-09-10 Journal: Lancet (London, England) [Category] 변종, [키워드] 95% CI adjusted odds ratio Admission African Analysis center Clinical severity Control COVID-19 COVID-19 case COVID-19 cases COVID-19 PCR test delta variant Department diagnosed diagnosed with COVID-19 disease control disease severity Factor finding foundation funding Genome sequencing Hospital admission hospitalisation hospitalisations hospitalised Immunity increase in individual infected individuals Infection infections Laboratory Laboratory test Medical Research Council Medicine Melinda Gate Melinda Gates multivariable logistic regression multivariable logistic regression models National Odds ratio Omicron variant PCR test PCR tests prevention proportion reduced reported S gene S gene target failure SARS-CoV-2 SARS-CoV-2 genome severe disease severity significantly significantly lower Society South South Africa TaqPath the SARS-CoV-2 Thermo Fisher Scientific variant Wellcome Trust [DOI] 10.1016/S0140-6736(22)00017-4 PMC 바로가기 [Article Type] Articles
Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trialResearch article Published on 2022-01-142022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adverse event adverse events AEs AEsAdverse events anti-S IgG anti-SARS-CoV-2 antibody binding Citadel clinical development Clinical research collected Concentration conducted COVID-19 COVID-19 vaccine dose Dose escalation earth effective ELISA enrolled enrolment EudraCT facility finding Follow-up force funding gene of Interest geometric mean GOIgene of Interest healthy individual Humoral response IgG ELISA immunoblot immunogenic induce injection interval intramuscular Joseph Lipid Lipid nanoparticle LNP LNPlipid nanoparticle London low dose low dose vaccine Medical Research Council neutralisation neutralisation assays non-structural protein NSPnon-structural protein Open-label participant partner Phase I post-hoc raised ranged required RNA RNA vaccine Safe Safety saRNAself-amplifying RNA SARS-CoV-2 self-amplifying RNA sera Serious Adverse Event Seroconversion serological evidence Trial Trust vaccination Vaccine VEEVVenezuelan equine encephalitis virus Venezuelan equine encephalitis virus was measured was related wild type [DOI] 10.1016/j.eclinm.2021.101262 [Article Type] Research article
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trialCovid-19 (회복)로 병원에 입원 한 환자의 아스피린 : 무작위, 통제, 오픈 라벨, 플랫폼 시험Randomized Controlled Trial Published on 2022-01-082022-08-13 Journal: Lancet (London, England) [Category] 임상, [키워드] (Medical Research Council) 1:1 95% CI absolute increase absolute reduction Accelerator allocation concealment Analysis anti-thrombotic properties Aspirin baseline bleeding composite endpoint COVID-19 death died discharge discharged duration of hospitalisation Efficacy and safety eligible enrolled evaluate finding funding hospital hospitalisation hospitalised hospitals in Indonesia hospitals in Nepal increase in Indonesia Innovation Intention intention to treat Invasive mechanical ventilation IQR ISRCTN major bleeding event major bleeding events median Medical Research Council Mortality Nepal no significant difference Open-label Patient per day Platform trial Primary outcome proportion randomisation randomised Randomly rate ratio receive RECOVERY trial reduction in reductions reductions in Registered risk risk ratio Standard of care subgroups of patients Therapeutics thrombotic thrombotic event Thrombotic events took place Treatment treatment for COVID-19 Trial usual care usual care alone web-based simple Wellcome Trust with COVID-19 [DOI] 10.1016/S0140-6736(21)01825-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Two-dose ChAdOx1 nCoV-19 vaccine protection against COVID-19 hospital admissions and deaths over time: a retrospective, population-based cohort study in Scotland and Brazil시간 경과에 따른 COVID-19 입원 및 사망에 대한 2회 접종 ChAdOx1 nCoV-19 백신 보호: 스코틀랜드와 브라질의 인구 기반 코호트 후향 연구Articles Published on 2022-01-012022-09-10 Journal: Lancet (London, England) [Category] Fulltext, SARS, 변종, [키워드] (Medical Research Council) 95% CI 95% CIs Abstract Acute respiratory infection Analysis association Booster vaccine Brazil Carlos Chaga Carlos Chagas ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 against ChAdOx1 nCoV-19 vaccine challenge Cohort cohort study cohorts COVID-19 COVID-19 vaccine database dataset death defined dominant dose Effectiveness estimate rate ratio estimate rate ratios Fazer finding Follow-up funding Health Data Research UK Hospital admission Hospital admissions Industrial Innovation investigated Laboratory testing material Medical Research Council mortality data National new SARS-CoV-2 outcome pattern Poisson regression population-based cohort rate ratios reflect report respiratory respiratory infection retrospective Rio de Janeiro risk RRs Scottish second dose severe COVID-19 Strategy Suspected translation vaccination Vaccine vaccine dose was used [DOI] 10.1016/S0140-6736(21)02754-9 PMC 바로가기 [Article Type] Articles
Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and ParticipationObservational Study Published on 2022-01-012022-10-05 Journal: American journal of physical medicine & rehabilitation [Category] 임상, [키워드] Brain Cognitive function Cognitive impairment COVID-19 COVID-19 infection cross-sectional domain Dyspnea fatigue function headache Impact impacted Increased life mechanisms median Medical Research Council Mild Mount Sinai outcomes Participation Patient persistent physical physical activity prevaccination Quality Quality of life reductions in reported Research scale scored Stress Study design Symptom Symptoms syndrome these symptom Treatment Trigger [DOI] 10.1097/PHM.0000000000001910 PMC 바로가기 [Article Type] Observational Study
Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control studyObservational Study Published on 2022-01-012022-10-04 Journal: The Lancet. Infectious Diseases [Category] 임상, [키워드] 1:1 95% CI adjusted age Analysis artificial association Asymptomatic BMI body-mass boost booster vaccinations case-control study Characteristics clinical trial Control control group Council COVID COVID-19 test COVID-19 vaccine demographics Department disease disease severity Effectiveness Efficacy effort Engineering Factor finding first vaccination FIVE foundation frailty funding geographical location had no Health health-care heart hospitalisation identify imaging implication individual individual symptoms individuals infected with SARS-CoV-2 Infection infection control Innovation intelligence less logistic regression model London measure Measures Medical Research Council negative test obesity odds of infection Odds ratio Older participant physical distancing Population positive positive COVID-19 Positive test Protective real-world data reduced reported risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Science second dose second vaccination selected Sex Society Support Symptom Symptoms tested the disease vaccinated individual vaccination Vaccinations Vaccine vaccine dose value Wellcome Trust [DOI] 10.1016/S1473-3099(21)00460-6 PMC 바로가기 [Article Type] Observational Study
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study우려의 알파(B.1.1.7) 변종과 비교한 SARS-CoV-2 델타(B.1.617.2)에 대한 입원 및 응급 치료 출석 위험: 코호트 연구Comparative Study Published on 2022-01-012022-09-10 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 변종, 치료기술, [키워드] adjust adjusted adjusted hazard ratio Admission age Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 both groups Care Cohort cohort study Cox regression data set dataset death delta variant Department Deprivation Digital dominant Emergency Emergency Care England Ethnicity finding funding Generation greater health-care health-care service health-care services hospital Hospital admission immunisation Innovation International lead Lineage median age Medical Research Council Mortality Most patient Most patients National NHS outbreak outcomes Patient patients with COVID-19 Precision predominant Public Health England Relative risk residence Result risk SARS-CoV-2 delta SARS-CoV-2 variant second secondary Sequencing service severe disease severity Sex specimen Stratified Cox regression subgroups System Transmissibility Travel unvaccinated population unvaccinated populations vaccination Vaccination Status variant was done was used whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00475-8 PMC 바로가기 [Article Type] Comparative Study
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysisSARS-CoV-2 변이체에 대한 보호 예측 인자로서의 중화 항체 역가 및 부스팅의 영향: 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Alpha analysed Analysis Antibody titre Beta booster vaccination correlated decrease decreases Effect Efficacy elicited Future In-vitro infected individual Infection infection with SARS-CoV-2 Medical Research Council medium Meta-analysis neutralisation neutralisation titre Neutralising activity not significantly different outcome predict predicted Predictive predictor reduced remained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serum Severe infection shown statistical model suggested symptomatic infection titre vaccination vaccination schedule Vaccine vaccine efficacy vaccine response vaccine responses Vaccines variant variants variants of concern virus virus infection waning immunity [DOI] 10.1016/S2666-5247(21)00267-6 PMC 바로가기 [Article Type] Meta-Analysis
COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort studyBNT162B2 및 Chadox1 NCOV-19 백신 접종 후 COVID-19 병원 입원 및 사망 (EAVE II) : 전향 적 코호트 연구Articles Published on 2021-12-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, COVID-19, Fulltext, SARS, [키워드] (Medical Research Council) 95% CI adjusted Admission Analysis BNT162b2 Care ChAdOx1 ChAdOx1 nCoV-19 challenge clinical factor clinical feature Comorbidities Comorbidity conducted COVID-19 COVID-19 hospitalisation COVID-19 illness COVID-19 mortality COVID-19 test COVID-19 vaccination programme COVID-19 vaccine death died enhanced estimate rate ratio finding first dose FIVE Frequency funding group Health Data Research UK help highest hospital Hospital admission hospitalisation hospitalised incidence individual individuals Industrial Innovation less male management Medical Research Council Mortality National Older age outcome pandemic Pfizer Pfizer–BioNTech platform Poisson regression model primary care prioritised vaccination prospective cohort study Protective rate ratios receiving risk risk of COVID-19 RRs RT-PCR testing SARS-COV-2 infection Scottish severe COVID-19 severe disease Social distancing measure social distancing measures Socioeconomic deprivation Strategy stratified study period Surveillance time-dependent Poisson regression model unvaccinated population unvaccinated populations vaccination Vaccine vaccine dose with COVID-19 [DOI] 10.1016/S2213-2600(21)00380-5 PMC 바로가기 [Article Type] Articles