Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approachSARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근Article Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] 3CLpro accelerate accession number aligned ammonia analyses Analysis analyzed antioxidant approach associations Bacillus Bacteria Bacterial biochemically chymotrypsin Chymotrypsin-like protease collected Compound computational tool coronavirus Culture docked docking scores drug-likeness effective enzyme flask culture flavonoid GenBank identify in silico analysis in-silico inhibitor Interaction isolate Lopinavir metabolite metabolites Micrococcus morphologically nine NMR nucleotide nucleotide sequence outcome performed phytohormone plant profiles protease protein-protein network protein-protein networks protocol Pseudomonas species rDNA reported Research Sanger sequencing Secondary Metabolite sequence similarity Staphylococcus structures submission target protein target proteins tested these compounds was performed were assessed [DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
Significant changes in follicular fluid phthalate metabolite levels reflect the lifestyle changes brought about by the strict COVID-19 lockdown in IndiaResearch article Published on 2022-08-012022-10-05 Journal: F&S science [Category] 유전자 메커니즘, [키워드] absence accumulated age analyzed BMI Care change changes in collected contributed coronavirus COVID-19 COVID-19 lockdown COVID-19 pandemic decrease Defense detect dibutyl phthalate Effect endocrine-disrupting chemicals evaluate flexible Follicular fluid group hospital human behavior hygiene in vitro In vitro fertilization include increase in India initiated injection lifestyle changes lockdown median metabolite metabolites objective Oocyte Personal protective equipment phthalates processed promoted reflect responsible screened seeking setting Significant significantly higher the median Treatment women [DOI] 10.1016/j.xfss.2022.06.001 [Article Type] Research article
A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main ProteaseSARS-CoV-2 주요 프로테아제를 표적으로 하는 천연 잠재적 억제제에 대한 다단계 인실리코 연구Article Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] ADMET battle binding binding mode Characteristics choice co-crystallized Compound compounds conducted COVID-19 determine determined by DFT docking exhibited FIVE in silico in vitro in vivo inhibitor Ligand M pro main protease MD simulations metabolite metabolites molecular molecular docking molecular dynamics natural natural antiviral PDB PDB ID performed pharmacophoric positive Potential protease SARS-CoV-2 SARS-CoV-2 main protease selected similarity simulation studies Simulation study structural similarity Structure targeting the SARS-CoV-2 thermodynamic Toxicity was determined [DOI] 10.3390/ijms23158407 PMC 바로가기 [Article Type] Article
Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severityCOVID-19 질병 중증도와 관련된 대사 산물, 단백질 및 조직 기능 장애Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] age Analysis anatomical approach biochemical pathway Biochemical pathways biological processe biological processes blood count blood count test changes in Characteristics clinical information complete blood count conjunction contribute COVID-19 Critical disease disease severity dysfunction Factor functional Gender Genome Health Health status Host Infection information Injury Interaction investigated liver lung machine learning algorithm Machine learning algorithms metabolite metabolites metabolomics molecular mechanism molecular mechanisms outcome Patient patient data predict presenting symptom profiles progression Protein proteomics provide response significant enrichment systemic inflammation tissue Treatment treatment of COVID-19 unstructured data with COVID-19 [DOI] 10.1038/s41598-022-16396-9 PMC 바로가기 [Article Type] Article
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses이중막 소포(DMV): SARS-CoV-2 및 기타 포지티브 센스 단일 가닥 RNA 바이러스 복제 전용 바이러스 유도 소기관Review Published on 2022-07-162022-09-11 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogy Antiviral approach autophagic biogenesis can not Cell organelle coronavirus COVID-19 Double-membrane vesicle Endoplasmic reticulum export Genome Golgi apparatus HCV hepatitis C hepatitis C virus host cell host cell membrane host cell membranes induce initial Innate immunity interactions involved lipid droplet lipid droplets lipids mechanism mechanisms membrane metabolite metabolites Mitochondria morphology non-structural protein organelle other coronavirus other coronaviruses pathogen phylogenetically positive-sense single-stranded RNA Positive-sense single-stranded RNA virus Replication replication of SARS-CoV-2 Replication organelle required RNA RNA virus SARS-CoV-2 sealed shown similarity single-stranded storage supply these viruses Vesicle viral replication Viral RNA virions virus Virus/cell interactions. viruses [DOI] 10.1007/s00018-022-04469-x PMC 바로가기 [Article Type] Review
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics Research Published on 2022-07-132022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] alteration analysed Analysis biofluid Blood changes in Cohort correlation COVID-19 COVID-19 infection dominant dyslipidaemia hallmark hospitalised immunostimulatory Lipid majority metabolite metabolites metabolomics negative controls participant Pathologies pathophysiological conditions Patient performed plasma positive profile provided Saliva salivary Sebum sensitivity Sensitivity and specificity serum specificity Triglyceride utilised [DOI] 10.1038/s41598-022-16123-4 [Article Type] Research
Paxlovid (Nirmatelvir/Ritonavir) and Tacrolimus Drug-Drug Interaction in a Kidney Transplant Patient with SARS-2-CoV infection: A Case ReportArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 치료제, [키워드] Acute kidney injury acute respiratory syndrome addition adverse effects Affect antiviral medication approved Awareness Case report Combination Community Consulting coronavirus disease dose drug-drug interaction Efficiency Emergency use enzyme health systems Immunocompromised patient Immunosuppressive medication increase induce inhibit inhibitor interactions kidney transplant medication metabolites New P450 pandemic Patient Paxlovid physician Prevent receive receiving recipient reduction rejection report risk Ritonavir robust SARS-CoV-2 serum creatinine Side effects Symptoms tacrolimus tested Transplant treat treated Treatment [DOI] 10.1016/j.transproceed.2022.04.015 PMC 바로가기
Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19Review article Published on 2022-07-012022-10-05 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis [DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding Research Published on 2022-07-012022-10-05 Journal: Cell Discovery [Category] 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation adaptive Analysis cell count Cell migration Classifier complement Course COVID-19 COVID-19 patient enhanced exhibited IgG antibody Immunity Inflammation liver longitudinal metabolites metabolomics pathway Patient predict proteomics receptor Regulatory RNA SARS-COV-2 infection sera subset suppressed the patient Treg Viral load viral replication Viral RNA Viral RNA shedding [DOI] 10.1038/s41421-022-00441-y [Article Type] Research
The significance of antiglobulin (Coombs) test reactivity in patients with COVID-19COVID-19 환자에서 항글로불린(Coombs) 검사 반응성의 중요성Article Published on 2022-07-012022-09-12 Journal: Immunobiology [Category] COVID19(2023년), MERS, SARS, 신약개발, 진단, [키워드] alteration Analysis Anemia Antiglobulin Antiglobulin (Coombs) test association autoantibody Autoimmune binding CAD Case report characterized Clinical finding complement system activation conducted COVID-19 COVID-19 patients Critical CRP cytokine D-dimer demonstrated described disease disease severity Erythrocytapheresis etiology Evidence examined hemoglobin Hemoglobinopathy Hemolysis hemolytic anemia hospitalized COVID-19 patient hyperinflammation ICU admission indirect bilirubin Laboratory lactate dehydrogenase mechanism metabolites pathophysiological Patient patients with COVID-19 peripheral smear positive RBC RBCs reactive reactivity red blood cell Retrospective study SARS-CoV-2 SARS-CoV-2 protein severity of COVID-19 statistically significant Symptom tested therapy treated Treatment understanding Univariate analysis worsening [DOI] 10.1016/j.imbio.2022.152240 PMC 바로가기 [Article Type] Article