Inhibitory effect of whey protein concentrate on SARS-CoV-2-targeted furin activity and spike protein-ACE2 binding in methotrexate-induced lung damageArticle Published on 2022-06-012023-07-07 Journal: Journal of food biochemistry [Category] COVID19(2023년), [키워드] COVID-19 Cytokines lung methotrexate SARS CoV-2 whey protein concentrate. [DOI] 10.1111/jfbc.14039
Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trialRandomized Controlled Trial Published on 2022-06-012023-07-08 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), [키워드] Arthritis COVID-19 methotrexate Rheumatoid vaccination [DOI] 10.1136/annrheumdis-2021-221916 [Article Type] Randomized Controlled Trial
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
Does an adjustment to the dosing and timing of immunomodulatory drugs alter the immunogenicity of the COVID-19 vaccines in patients with autoimmune and inflammatory rheumatic disease (AIIRD)?Article Published on 2022-05-012023-07-09 Journal: RMD Open [Category] COVID19(2023년), [키워드] Arthritis, Rheumatoid biological therapy COVID-19 methotrexate vaccination [DOI] 10.1136/rmdopen-2022-002203 PMC 바로가기
Risk of herpes zoster in patients with rheumatoid arthritis in the biologics era from 2011 to 2015 and its association with methotrexate, biologics, and corticosteroids2011년부터 2015년까지 생물학적 제제 시대의 류마티스 관절염 환자에서 대상포진의 위험과 메토트렉세이트, 생물학적 제제 및 코르티코스테로이드와의 연관성Article Published on 2022-04-182023-05-31 Journal: Modern rheumatology [Category] 대상포진, 두창, 수두, 홍역, [키워드] Biologic disease-modifying antirheumatic drug Corticosteroid herpes zoster methotrexate rheumatoid arthritis [DOI] 10.1093/mr/roab026
Evidence-based efficacy of methotrexate in adult Crohn’s disease in different intestinal and extraintestinal indicationsSystematic Review Published on 2022-03-232024-09-04 Journal: Therapeutic Advances in Gastroenterology [Category] 대상포진, [키워드] Crohn’s disease extraintestinal manifestations methotrexate [DOI] 10.1177/17562848221085889 PMC 바로가기 [Article Type] Systematic Review
Severe varicella in a child immunosuppressed with methotrexateCase Reports Published on 2022-03-012023-05-31 Journal: Anais Brasileiros de Dermatologia [Category] 두창, 수두, 홍역, [키워드] Immunosuppression methotrexate psoriasis varicella [DOI] 10.1016/j.abd.2020.10.017 PMC 바로가기 [Article Type] Case Reports
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung CancerArticle Published on 2022-02-012022-10-04 Journal: Inflammation [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 ACE2 expression acute respiratory syndrome affected angiotensin-converting enzyme 2 Atla Cell characteristic coronavirus Correlation analysis COVID-19 COVID-19 patient Critical dataset dysregulated effective therapy expression expressions FBP Folate-binding protein gp130 IL-6 IL6 increase in indicated Infection Inflammation Inflammatory response Inflammatory responses inverse correlation lesson Loss lung adenocarcinoma lung cancer lung tissue injury methotrexate Phosphorylation Protein qRT-PCR analysis repurposing rescued SARS-CoV-2 SARS-COV-2 infection similarity Spearman suggested transfected cells Treatment [DOI] 10.1007/s10753-021-01536-6 PMC 바로가기 [Article Type] Article
Attenuated anti-SARS-CoV-2 antibody response to vaccination in patients with rheumatic diseases류마티스 질환 환자에서 백신 접종에 대한 약화된 항-SARS-CoV-2 항체 반응Article Published on 2022-02-012022-09-12 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract anti-SARS-CoV-2 antibody COVID-19 IMID methotrexate mRNA vaccine Patient psoriatic arthritis response to vaccination rheumatic disease Rheumatoid rheumatoid arthritis SARS-CoV-2 spondyloarthritis vaccination Viral vector vaccine [DOI] 10.1016/j.jinf.2021.12.006 PMC 바로가기 [Article Type] Article