Microbial Ecology and Evolution Are Essential for Understanding PandemicsCommentary Published on 2021-09-282022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] Abstract appear cause COVID-19 COVID-19 pandemic COVID-19 research Critical disperse ecological Ecology Essential Evolution finding microbe microbes Microbial ecology microbial evolution Microbiome pathogenic Population question SARS-CoV-2 understanding virus [DOI] 10.1128/mBio.02144-21 PMC 바로가기 [Article Type] Commentary
The Possible Role of Microbial Proteases in Facilitating SARS-CoV-2 Brain InvasionOpinion Published on 2021-09-272022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 activate Angiotensin-converting enzyme Brain Cell cells Co-infection Cryptococcus Endothelial cell expression facilitate Facilitating fungal glycoprotein information instance Intervention Invasion Measures mechanism membrane fusion microbe microbial neurotropism organ Pathogens protease role S2 domain SARS-CoV-2 secretion shown simple understanding viral spike virus [DOI] 10.3390/biology10100966 PMC 바로가기 [Article Type] Opinion
Bacterial and fungal growth in sputum cultures from 165 COVID-19 pneumonia patients requiring intubation: evidence for antimicrobial resistance development and analysis of risk factorsResearch Published on 2021-09-252022-10-28 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval age Analysis Antibiotic resistance Antibiotics Antimicrobial stewardship Antimicrobials Bacterial bacterial superinfection cause Clinical course Clinical findings Community conducted correlated COVID-19 COVID-19 illness COVID-19 pneumonia patient COVID-19 pneumonia patients Culture cultures determine Enterobacter evaluated Evidence expressed finding Frequency fungal Fungal infection ground glass growth highest hospital hospitalisation Independence individual interstitial Intubated intubation Laboratory testing lack Length LOS microbe not applicable objective outcome overall mortality pathogen Patient Pneumonia positive potential risk Pseudomona Radiographic raised Result retrospective retrospective review risk factor SARS-CoV-2 Severe COVID-19 pneumonia severe pneumonia significance level sputum sputum culture Staphylococcus aureus Test two-sided United States worsened [DOI] 10.1186/s12941-021-00472-5 PMC 바로가기 [Article Type] Research
Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2Review Published on 2021-09-132022-10-30 Journal: Natural Products and Bioprospecting [Category] COVID-19, [키워드] Against antivirals Bacteria caused Compound Concentration conducted coronavirus COVID-19 infection cut off drug Drug discovery fungi Infection Infectious disease inhibitors inhibitory concentration Lead compounds limit microbe natural natural products pandemic Potential product Research responsible resulting Saponin SARS-CoV-2 scaled up Spread target proteins the disease Therapies therapy Vaccine viral infection virus viruses [DOI] 10.1007/s13659-021-00317-w PMC 바로가기 [Article Type] Review
Biologia Futura: use of biocides during COVID-19-global reshuffling of the microbiotaBiologia Futura: 미생물총의 COVID-19 전 세계적인 재편성 중 살생물제 사용Review Published on 2021-09-012022-09-11 Journal: Biologia futura [Category] SARS, 변종, [키워드] Affect aggregation Agroecosystem article attacked biocides Biologia causative agent competition Complete Concentration country COVID-19 creating decrease Diversity ecosystem excessive use Extensive Fertility flourishing global pandemic Impact lockdown management measure microbe microbial flora Microbiome microbiota mutated neutralization Novel coronavirus pandemic Panic pathogenicity pros Result SARS-CoV-2 Spread strain Surface water virus water wildfire [DOI] 10.1007/s42977-021-00069-1 PMC 바로가기 [Article Type] Review
Neuropathy in COVID-19 associated with dysbiosis-related inflammationArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Affect association Brain circulatory system Complication complications conditions contribute COVID-19 COVID-19 patient COVID-19 severity cytokine described diarrhea disease distal gastrointestinal system Gut gut microbiota gut microbiota dysbiosis gut–brain axis gut–lung axis homeostasis Host immune dysfunction immune response immune system impair induce Inflammation involved Kynurenine pathway lung maintain metabolite microbe microbial microbial product microbiota neurodegenerative Neuroinflammation neurologic Neurological symptom neuropathic Neuropathy organ Pain pathophysiology Patient patients with COVID-19 resulting SARS-COV-2 infection severe COVID-19 patient severity systemic inflammation the disease translocation turn [DOI] 10.3906/biy-2105-53 PMC 바로가기 [Article Type] Article
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens3가 MMR 및 Tdap 백신 항원에 의해 유도된 COVID-19의 보호 이종 T 세포 면역Clinical and Translational Article Published on 2021-08-142022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 백일해, 임상, 진단, 치료기술, 치료법, [키워드] Abstract Activation acute respiratory syndrome Administered Analysis Anti-viral immunity Antibody titers Antigen antigen presenting cells antigens APC assays autologous CD45RA Cell co-cultured Cohort Context Control coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination cross-reactive death disease severity Donor driving Effect effective effector memory elicit ELISA ELISPOT ENhance enzyme-linked immunospot epitope feature Features finding flow cytometry foundation funding Heterologous heterologous immunity IFN-γ IL-15 Immunity implicated individual individuals Infection interferon-γ investigated memory memory T cells microbe mitigate MMR nucleocapsid outcomes overlapping Participants Pathogens phenotype promote PROTECT Protective Protein Reactivation recognizing reduced required response risk prediction SARS-CoV-2 SARS-CoV-2 antigen scRNA-seq severe COVID-19 Single-cell RNA sequencing subset supported T cell TCR TCR repertoire transcriptional Transcriptome trivalent uninfected vaccination Vaccine vaccine antigen Vaccines validation study viral infection with mild disease [DOI] 10.1016/j.medj.2021.08.004 PMC 바로가기 [Article Type] Clinical and Translational Article
Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model경증 및 중증 SARS-CoV-2 감염은 K18-hACE2 형질전환 마우스 모델에서 호흡기 및 장내 미생물군유전체 변화를 유도합니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Antiviral Antiviral treatment Bacteroidete Bacteroidetes cecum change changes in characterized Clinical sign Clinical signs coronavirus COVID-19 COVID-19 pandemic death deaths declining Decreased develop disease dissimilarity dosage dose dose-dependent manner family Firmicute firmicutes groups hACE2 High dose High-dose immune system increasingly independent independent of Infection inhibitor intestinal intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice less lung Lungs M pro mice microbe microbes microbial Microbiome Model mouse presence or absence prevalent Proteobacteria respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 significantly Treatment Verrucomicrobia Viral viral infections virus with infection [DOI] 10.1128/Spectrum.00536-21 PMC 바로가기 [Article Type] Research Article
Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens슈도모나스 단백질 겐에서 표현형 및 유전 적 결과의 예측Research Article Published on 2021-08-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation adaptive addition Air-liquid interface Amino acid Bacterial Biological Biology can not Cancer Cellulose changed Climate change colonize condition conditions conserved core dependent on develop Diseases disrupt Evolution expected experiments Factor fitness followed by Forecasting Genetic Genotype growth hot spot identity Infectious diseases lack majority mathematical mathematical model microbe microbes model system model systems MOST motility mutant mutants Mutation mutation rate Mutation rates mutations negative regulation nucleotide outcome outcomes pathway phenotype Phenotypes phenotypic polysaccharide Population predict predictability predicted predicted gene predicted genes Predictive model prevented problems promoter regions Protein provide Pseudomona Pseudomonas Pseudomonas species Pseudomonas specy real time reduced Region resulting sequence tested Variation [DOI] 10.1371/journal.pgen.1009722 PMC 바로가기 [Article Type] Research Article
Metatranscriptomic Characterization of Coronavirus Disease 2019 Identified a Host Transcriptional Classifier Associated With Immune Signaling코로나바이러스 질병 2019의 메타전사 특성화는 면역 신호와 관련된 숙주 전사 분류기를 확인했습니다Article Published on 2021-08-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway Alpha Analysis analyzed caused characteristics of patient characterization Classifier concurrent infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 diagnosis COVID-19 patient COVID-19 patients cytokine signaling diagnosing Diagnosis differentially expressed gene Differentially expressed genes disease severity elements evaluated examined exhibited gene analysis Host host gene Host immune response host responses Identified immune pathways Infection Interferon-gamma metatranscriptomic metatranscriptomics. microbe Microbiome Non-COVID-19 Novel coronavirus outbreak pandemic pathogenic Pathogens Pathways Patient Pneumonia pneumonias promise reduced respiratory illnesses respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling significantly transcriptional with COVID-19 [DOI] 10.1093/cid/ciaa663 PMC 바로가기 [Article Type] Article