Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2바이러스 감염의 Gal-3BP: 중증 급성 호흡기 증후군 코로나바이러스 2의 새로운 역할Review Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] addition antiviral activity antiviral immune response attenuate binding Biomarkers Cancer circulating complex components coronavirus 2 correlation Cytokines disease Disease progression disease severity evaluate expression Factor Gal-3BP galectin-3 glycoprotein HCV HIV-1 IFNs IL-6 in viral induce Infection Interaction interferons interferons (IFNs interferons (IFNs) interleukin interleukin-6 involved knowledge modulation molecular mechanism molecular mechanisms multifunctional prognostic biomarker progression proinflammatory cytokines Protein respiratory role SARS-CoV-2 severe disease Severity of disease Signaling TGF-β TNF TRAF upregulated upregulation Viral diseases viral infections virus virus infection virus infection. [DOI] 10.3390/ijms23137314 PMC 바로가기 [Article Type] Review
Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected MiceSARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathogenesis. pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication [DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article
An insight to the therapeutic potential of algae-derived sulfated polysaccharides and polyunsaturated fatty acids: Focusing on the COVID-19Review article Published on 2022-06-012022-10-05 Journal: International journal of biological macromolecules [Category] 변종, 치료제, [키워드] addition affected Algae candidate Compound coronavirus COVID-19 COVID-19 case Critical Effectiveness fatty Fatty acid Focusing Gut gut microbiome Health immune regulation immune system immunomodulatory activities immunomodulatory property Infection infections intestine Microbiome microbiota modulate modulating modulation Mutation nutritional intervention other organ pandemic Polyunsaturated Polyunsaturated fatty acids Prevent produced Research resources response sulfated polysaccharide sulfated polysaccharides the vaccine therapeutic therapeutic potential these compound Treatment Vaccine viral infections virus virus pathogenesis [DOI] 10.1016/j.ijbiomac.2022.03.063 [Article Type] Review article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
Potential plants for inflammatory dysfunction in the SARS-CoV-2 infectionSARS-CoV-2 감염에서 염증 기능 장애에 대한 잠재적 식물Review Published on 2022-06-012022-09-11 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects antioxidant appear cardiovascular risk characterized clinical trial clinical trials CRP Cytokines described disease dysfunction Effects Efficacy evaluate form homeostasis IFN-γ IL-1 IL-6 Infection Inflammation Inflammatory Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory process marker mechanism modulation organism oxidative plant plants Potential pro-inflammatory cytokine responsible SARS-CoV-2 SARS-COV-2 infection selected significantly increased systematic review the SARS-CoV-2 therapeutic effects Therapeutic effects. TNF-a [DOI] 10.1007/s10787-022-00981-5 PMC 바로가기 [Article Type] Review
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection Research Published on 2022-05-122022-10-05 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] approach approved Baricitinib can be used drug-target Effect elevated Evidence explain HCV highlight hypomagnesemia identification identify in vitro assays in vitro study include increased risk Interaction JAK inhibitor jak inhibitors Ligand machine learning approach mechanism modulation PDE10A pharmacological PKN2 Potential predict required risk similarity target thrombosis Tofacitinib TRPM6 Vascular viral infection while [DOI] 10.1038/s41598-022-11879-1 [Article Type] Research
Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S ProteasomeSARS-CoV-2 주요 프로테아제 및 20S 프로테아좀의 공유 억제제의 절대 결합 자유 에너지의 빠르고 효과적인 예측Article Published on 2022-05-042022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerated activities Amino acid applicability approach binding affinities binding affinity binding free energy cause computational method covalent bond COVID-19 COVID-19 pandemic Degradation drug Effect effective electrophilic energetics energy enzyme evaluate exploration Free globe inhibitor inhibitors inhibitors of SARS-CoV-2 interactions M pro modulation powerful tool prediction protease proteasome Protein protocol public health emergency reaction reservation robust SARS-CoV-2 shown significantly target Therapeutic strategies variant warhead water [DOI] 10.1021/jacs.2c00853 PMC 바로가기 [Article Type] Article
CT-based severity assessment for COVID-19 using weakly supervised non-local CNNResearch article Published on 2022-05-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, [키워드] 3D CNN absolute difference accelerated approach artificial Clinical data CNN consolidation COVID-19 COVID-19 severity Critical CT scan dataset deep learning displaying Evaluating explicit feature Features ground-glass opacity Guidance Infection intelligence labeling learning manifestation mechanism modulation Non-local attention Patient prognostic resulting severity Squeeze treatment protocols Variability [DOI] 10.1016/j.asoc.2022.108765 [Article Type] Research article
COVID-19 article altimg-small=kintcovid_s.svg altimg=kintcovid_o.svg>Occurrence of De novo Donor-Specific Antibodies After COVID-19 in Kidney Transplant Recipients Is Low Despite Immunosuppression ModulationResearch article Published on 2022-05-012022-10-05 Journal: Kidney International Reports [Category] 치료제, [키워드] age allograft rejection antibody antibody screening Antigen antimetabolite antiviral therapy calcineurin coronavirus disease COVID-19 COVID-19 severity death Decreased DSA evaluated Follow-up French HLA Hospitalized immune response Immunosuppression incidence Infection inflammatory markers inhibitor investigated kidney transplant recipient leukocyte lymphopenia median time modulation occurred Occurrence Patient patients recipient recruited rejection Result significant decrease Transplant were excluded were recorded [DOI] 10.1016/j.ekir.2022.01.1072 [Article Type] Research article