mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses Research Published on 2022-08-262022-10-05 Journal: Communications Biology [Category] 바이오마커, 진단, [키워드] activate Analysis cardiovascular disease catalytic Coagulopathy expression gene product IL-1β IL-6 immune cell type Inflammatory Inflammatory response limit LPS mechanism metabolism monocyte Monocytes mTOR inhibitor NAD+ pathway polyfunctional responses primary human monocyte pro-inflammatory pro-inflammatory cytokine procoagulant Regulation response risk Support tested tissue TLR4 transcriptional activity transcriptional response Treatment with HIV [DOI] 10.1038/s42003-022-03804-z [Article Type] Research
High Monocyte Count Associated with Human Cytomegalovirus Replication In Vivo and Glucocorticoid Therapy May Be a Hallmark of DiseaseArticle Published on 2022-08-242022-11-16 Journal: International Journal of Molecular Sciences [Category] 치료기술, [키워드] caused CD14 Characteristics clinical model/translational medicine clinical response Clinical symptoms CMV comparable correlated corticosteroid therapy count COVID-19 cytomegalovirus cytomegalovirus (CMV) kinetics decrease defined definitions of cytomegalovirus disease described Dexamethasone disease dose glucocorticoid growth hallmark healthy subjects homogeneous homogeneous sample of subjects logarithmic phase of infection Human Increased Infection Infectious disease innate immune innate immune response investigated leukopenia lymphopenia macrophages molecular monocyte monocytes characteristics and analysis monocytosis mononucleosis neutropenia observation onset of fever pathogen detection Patient prodrome Replication Sample Significant steroid subject syndrome tested the median viral infection Viral load viral replication Viremia virome virus virus replication [DOI] 10.3390/ijms23179595 PMC 바로가기
Reliability of predictive models to support early decision making in the emergency department for patients with confirmed diagnosis of COVID-19: the Pescara Covid Hospital scoreCOVID-19 진단이 확인된 환자의 응급실에서 조기 의사 결정을 지원하는 예측 모델의 신뢰성: Pescara Covid Hospital 점수Article Published on 2022-08-192022-09-11 Journal: BMC health services research [Category] 변종, [키워드] Abruzzo Accuracy Admission age and gender Algorithm Alpha build calibrated can be used carried Characteristics clinical decision collecting data conditions COVID-19 D-dimer death decision Decision making diabete diabetes diagnosed with COVID-19 Diagnosis disease distribution emergency department heterogeneous higher risk hospital hospital management hospitalisation identify independent predictor independent predictors initial intensive care Italy laboratory parameter Laboratory parameters Lactate lactate dehydrogenase Logistic regression monocyte other variant other variants outcome oxygen oxygen support pandemic parameter Patient patients with COVID-19 prediction Prediction score Predictive model predictive models predictor procalcitonin Prognosis renal renal disease Retrospective study risk Risk scores risk stratification saturation significantly Support survival threshold validation variants of concern virus were used [DOI] 10.1186/s12913-022-08421-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity상승된 Myl9는 SARS-CoV-2 유발 폐삼출성 혈관염에서 Myl9 함유 미세혈전을 반영하고 COVID-19 중증도를 예측합니다Article Published on 2022-08-162022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accompanied accumulated activation of platelets acute respiratory syndrome Analysis Autopsy Clinical severity coronavirus coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 severity exudative vasculitis fatal disease histological immune dysregulation immunothrombosis lung marker Microscopy microthrombi monocyte mononuclear cell Mortality nonconventional monocytes Pathogenesis pathology Peripheral blood plasma plasma Myl9. predict provide reflect SARS-CoV-2 severity Single-cell RNA sequencing the disease treatment for COVID-19 Vascular Vasculitis vessels X-ray spectroscopy [DOI] 10.1073/pnas.2203437119 PMC 바로가기 [Article Type] Article
Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis PatientsArticle Published on 2022-08-092023-07-11 Journal: Kidney360 [Category] COVID19(2023년), [키워드] Basic science Chronic kidney disease COVID-19 dendritic cell immune response Innate immunity monocyte mRNA vaccine SARS-CoV-2 [DOI] 10.34067/KID.0002542022 PMC 바로가기
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosisCOVID-19 폐 질환은 특발성 폐 섬유증과 드라이버 AT2 세포 변성 기능을 공유합니다Article Published on 2022-08-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, [키워드] alveolar Alveolar Type II Alveolar type II pneumocytes Analysis analyzed approach artificial Artificial intelligence/machine learning AT2 cells change changes condition COVID COVID-19 Cytokine storm cytopathic Damage-associated transient progenitor (DATP) dataset Deceased determinant develop disease Disease model disease models Diseases DNA damage driven by driver dysfunction effective ER stress ER-stress feature gene expression pattern gene signatures hamsters Host immune response human lung identify Idiopathic pulmonary fibrosis IHC immune response immunohistochemistry Injury interleukin Interleukin 15 (IL15) Interstitial lung diseases IPF lack Like lung Lung disease Lungs molecular monocyte pandemic Pathogenesis Patient patients with IPF Perspective phenotype PPI Prognosis prognostic Program protein-protein interaction pulmonary fibrosis qPCR reversed SARS-CoV-2 SASP senescence similarity subject supported therapy transcriptomic Treatment Trigger were used with COVID-19 [DOI] 10.1016/j.ebiom.2022.104185 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱Article Published on 2022-08-012022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing the SARS-CoV-2 vaccination Vaccine [DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article
Evaluation of hematological parameters and inflammatory markers in children with COVID-19COVID-19 소아의 혈액학적 매개변수 및 염증 표지자 평가Article Published on 2022-08-012022-09-11 Journal: Irish Journal of Medical Science [Category] 바이오마커, [키워드] 95% CI abnormality applied best blood cell C-reactive protein C-reactive protein (CRP can be used children children with COVID-19 COVID-19 CRP cutoff value D-dimer determine distribution Effect evaluate hematological hematological parameter hematological parameters hemoglobin Hospitalization identify independent predictor independent predictors Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Inpatient Inpatients lymphocyte lymphopenia mean platelet volume monocyte multivariate logistic regression neutrophil Outpatient outpatients Patient Platelet platelet counts procalcitonin procalcitonin level Red cell retrospective risk factor Risk factors ROC analysis separated significantly higher significantly lower single-center study study population two groups Volume was performed WBC White blood cell [DOI] 10.1007/s11845-021-02762-5 PMC 바로가기 [Article Type] Article