A short focus, azithromycin in the treatment of respiratory viral infection COVID-19: efficacy or inefficacy?짧은 초점, 호흡기 바이러스 감염 COVID-19 치료에서 아지스로마이신: 효능 또는 비효율?Review Published on 2022-02-012022-09-11 Journal: Immunologic research [Category] COVID19(2023년), SARS, 치료제, [키워드] acting addition antibiotic antiviral efficacy antiviral properties arrhythmia Arrhythmias assumed Azithromycin Clinical data Combination COVID-19 demonstrated determine Efficacy Evidence global pandemic immunomodulatory in vitro in vitro activity Infection Macrolide mechanism mechanism of action monotherapy Pneumonia pulmonary recent reported respiratory tract respiratory tract infection Respiratory tract infections respiratory viral infection responsible SARS-CoV-2 therapeutic efficacy Treatment variety viral respiratory Virology viruses [DOI] 10.1007/s12026-021-09244-x PMC 바로가기 [Article Type] Review
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical SiblingsImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] 10x Analysis approach BNT162b2 Cell cellular chimerism clinical trial Combined COVID - 19 declining disease Donor dose Europe feasible female genetic profile hematopoietic Hematopoietic stem cell Hematopoietic stem cell transplantation (HSCT) humoral immune responsiveness Immunity immunocompetence immunological tolerance immunology Immunosuppression induce induction induction of tolerance Infection kidney Kidney transplantation lymphoid male Microscope molecular monotherapy mRNA vaccine occurred pandemic Patient patients previous study protocol Quality of life rejection sibling Specific Stanford STEM Stem cell transplantation steroid T cell the SARS-CoV-2 Tolerance transplantation was performed [DOI] 10.3389/fimmu.2022.796456 PMC 바로가기 [Article Type] Immunology
Clinical outcomes of immunomodulatory therapies in the management of COVID-19: A tertiary-care experience from PakistanResearch Article Published on 2022-01-272022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] Administered Admission age Antibiotic resistance Azithromycin benefit Care clinical Clinical efficacy Combination conducted COVID-19 Critical drug combination effective greater highlight Hydrocortisone Immunomodulatory agent immunomodulatory therapy implication in-hospital mortality interquartile range IQR Karachi management median age medication Methylprednisolone monotherapy Mortality outcome Patient patients patients hospitalized pharmacological management polymerase chain retrospective cohort study significantly the patient [DOI] 10.1371/journal.pone.0262608 PMC 바로가기 [Article Type] Research Article
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)Article Published on 2022-01-112022-10-04 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상, [키워드] Abstract administration Anti-inflammatory approach ARDS blockade challenge chemokine Clinical data clinical trial combination therapy Concentration coronavirus disease-2019 COVID-19 Cytokine storm Cytokines dosage downstream drugs dysregulated immune response Efficacy explained Future Health hepatic injury highest Hyperinflammatory IL-6 IL-6 inhibitor IL-6 pathway IL-6 signaling IMPROVE interleukin-6 Jak-STAT Janus-kinase inhibitor lung damage membrane monotherapy non-specific Pathways pleiotropic pro-inflammatory progression pulmonary damage recent receptor reduce risk sarilumab severe coronavirus disease severe COVID-19 Side effect Signaling therapeutic approaches Tocilizumab Treatment [DOI] 10.1016/j.intimp.2022.108536 PMC 바로가기 [Article Type] Article
Humoral response to mRNA anti-COVID-19 vaccines BNT162b2 and mRNA-1273 in patients with chronic lymphocytic leukemia만성 림프구성 백혈병 환자에서 mRNA 항-COVID-19 백신 BNT162b2 및 mRNA-1273에 대한 체액 반응Article Published on 2022-01-112022-09-12 Journal: Blood advances [Category] SARS, 진단, [키워드] absence acute respiratory syndrome age anti-CD20 Antibody Response BNT162b2 CLL Combination coronavirus COVID-19 dose evaluate highest Humoral response immune response independent predictor individual inhibitor leukemia monoclonal antibody monotherapy mRNA mRNA-1273 mRNA-1273 vaccine multivariable analysis neutralizing monoclonal antibodies Older Patient post-dose Prophylactic provide receiving response rate risk SARS-CoV-2 second dose Seroconversion seronegative seronegative patient significantly higher single dose therapy treated Treatment treatment-naïve patient tyrosine vaccination Vaccine venetoclax [DOI] 10.1182/bloodadvances.2021006215 PMC 바로가기 [Article Type] Article
SARS-CoV2-specific Humoral and T-cell Immune Response After Second Vaccination in Liver Cirrhosis and Transplant Patients간경변 및 이식 환자에서 2차 예방접종 후 SARS-CoV 2 특이 체액 및 T 세포 면역 반응Article Published on 2022-01-012022-09-12 Journal: Clinical gastroenterology and hepatology : the off [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 titer Arterial hypertension booster vaccinations cirrhosis Cohort Control controls coronavirus develop DiaSorin Effect Elecsy Euroimmun healthy control Heterologous humoral identify immune response immunoassay Immunosuppression immunosuppressive information inhibitor less LIAISON liver Liver cirrhosis liver transplant recipients Logistic regression analysis monotherapy Odds ratio Patient patient groups predictor prospective cohort study RBD recipient recipients reduction regimen Research response Roche routine SARS-CoV-2 SARS-CoV-2 vaccination second second vaccination Seroconversion Serological testing spike-protein spike-specific T-cell response T-cell T-cell Response Transplant trimer vaccination was performed [DOI] 10.1016/j.cgh.2021.09.003 PMC 바로가기 [Article Type] Article
Efficacy of the BNT162b2 mRNA COVID-19 Vaccine in Patients with Chronic Lymphocytic Leukemia: A Serologic and Cellular Study만성 림프구성 백혈병 환자에서 BNT162b2 mRNA COVID-19 백신의 효능: 혈청 및 세포 연구Article Published on 2022-01-012022-09-12 Journal: Chemotherapy [Category] SARS, 진단, [키워드] acute respiratory syndrome age Analysis anti-CD20 antibody antibody response rate association BNT162b2 BNT162b2 mRNA BNT162b2 vaccine cellular immunity cellular response chronic chronic lymphocytic leukemia CLL CLL patient coronavirus correlation COVID-19 COVID-19 vaccination dosage healthy control highest humoral immune increase in independent predictor inhibitor leukemia median time Messenger RNA monotherapy mRNA NK cell pathway Patient patients positive cells respond SARS-CoV-2 SARS-CoV-2 vaccination second dose serologic Serologic response serological response Severe acute respiratory syndrome coronavirus 2 mRNA vaccination Sex sustained T-cell T-cell assessment. the SARS-CoV-2 therapy treated unlikely vaccination Vaccine vaccine dose [DOI] 10.1159/000521229 PMC 바로가기 [Article Type] Article
Evaluation of minocycline combined with favipiravir therapy in coronavirus disease 2019 patients: A case-series study코로나바이러스 질환 2019 환자에서 파비피라비르 요법과 결합된 미노사이클린의 평가: 사례 시리즈 연구Article Published on 2022-01-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료제, [키워드] acute respiratory syndrome adverse event anti-inflammatory activity antibacterial activity Antiviral Chain Reaction changes in chemokine combination therapy Control control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine and chemokine production Cytokines duration of fever duration of hospitalization Efficacy and safety Endpoint evaluated Favipiravir greater groups hospital Inflammatory cytokines interleukin interleukin-6 interleukin-8 Japan MIN Minocycline monotherapy Negative PCR no difference Patient PCR test polymerase chain polymerase chain reaction reduction reported Retrospective study SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases significantly significantly shorter Support therapy Treatment treatment initiation [DOI] 10.1016/j.jiac.2021.09.016 PMC 바로가기 [Article Type] Article
Implementation of an Emergency Department-Embedded Infusion Center for the Administration of Monoclonal Antibody Therapy in Patients With Early COVID-19 Infection초기 COVID-19 감염 환자의 단일클론항체 치료를 위한 응급실 내장 수액센터 구축Article Published on 2022-01-012022-09-12 Journal: Journal of infusion nursing : the official publica [Category] SARS, 진단, [키워드] administration Care center combination therapy Community coronavirus disease COVID-19 Emergency Emergency use authorization Immunocompromised individual infusion monotherapy offered Outpatient pandemic Patient receive resource risk Safe tested therapy Treatment [DOI] 10.1097/NAN.0000000000000453 PMC 바로가기 [Article Type] Article
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together밤라니비맙 단독 또는 밤라니비맙과 에테세비맙을 함께 투여받은 경증 또는 중등도 COVID-19 환자에서 SARS-CoV-2에 대한 내인성 항체 반응Clinical Trial Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, 치료법, 치료제, [키워드] Administered antibodies Antibody Response Antibody titer Antibody titers antigenic B.1.351 bamlanivimab baseline Beta Beta variant binding breadth clinically Cohort collected correlated COVID-19 Day decrease develop domain Effect endogenous epitope Epitopes etesevimab evade Factor full-length Hospitalization humoral immune response in viral investigated longitudinal mAb mAbs Mild Moderate COVID-19 monoclonal antibody monotherapy Mortality multiplex mutant N-terminal domain Neutralization assay Neutralizing activity neutralizing monoclonal antibodies nucleocapsid protein Patient performed Placebo Received receiving recipient reduced reductions in response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 pseudovirus sera serology serum sample specificity subsequent titer titers treated Treatment Trial variant Viral Viral load [DOI] 10.3389/fimmu.2021.790469 PMC 바로가기 [Article Type] Clinical Trial