mRNA-based vaccine – Page 4 – Communicable Diseases Research

Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern

3가지 COVID-19 백신이 우려하는 변이체에 대해 유도된 IgG/IgA 중화 효과의 비교 분석

Article

Published on 2022-04-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,

Postvaccination infections among staff of a tertiary care hospital after vaccination with severe acute respiratory syndrome coronavirus 2 vector and mRNA-based vaccines

중증급성호흡기증후군 코로나바이러스 2 벡터 및 mRNA 기반 백신 접종 후 3차 병원 직원 중 접종 후 감염

Observational Study

Published on 2022-04-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Alpha variant analysed Antigen B.1.1.7 B.1.351 B.1.617.2 Beta Beta variant BNT162b2 Breakthrough infection breakthrough infections Care ChAdOx1 ChAdOx1-S cohort study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined Delta delta variant demographic data dose effective first dose follow-up period hazard ratio hazard ratios hospital Hospital employees Hospitalization incidence Infection mRNA mRNA-based vaccine mRNA-based vaccine. not differ Observational cohort study Participants positive PCR positive PCR test postvaccination Postvaccination infection reported respiratory specimen retrospective retrospective observational cohort study RNA SARS-CoV-2 SARS-CoV-2 vaccine second dose severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen vaccination Vaccination Status Vaccine vaccine dose vaccine doses variant Vector-based vaccine Viral load virus variants
[DOI] 10.1016/j.cmi.2021.11.023 PMC 바로가기 [Article Type] Observational Study

Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA COVID-19 vaccine

BNT162b2 mRNA COVID-19 백신에 대한 신속한 반응과 관련된 혈소판 및 면역 신호

Article

Published on 2022-04-012022-09-12
Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), SARS, 진단,

[키워드] aggregates B cells Biomarker BNT162b2 BNT162b2 mRNA CD31 circulating platelet COVID-19 COVID-19 vaccine Critical cytokine response dose effective Efficacy elevated enrolled eosinophils expressed feature females first dose healthy volunteer humoral identify immune response immune signature immune system Immunity inhibitory leukocyte median motif mounted mRNA-based COVID-19 vaccine mRNA-based vaccine neutralizing antibody non-classical monocyte of BNT162b2 participant Platelet platelet activation Platelet count rapid immune response rapid response reactive receptor responders second dose stability stimulate the vaccine Vaccine Vaccines Vascular
[DOI] 10.1111/jth.15648 PMC 바로가기 [Article Type] Article

Humoral and Cellular Immunogenicity and Safety of Five Different SARS-CoV-2 Vaccines in Patients With Autoimmune Rheumatic and Musculoskeletal Diseases in Remission or With Low Disease Activity and in Healthy Controls: A Single Center Study

자가면역 류마티스 및 근골격계 질환 환자에서 5가지 다른 SARS-CoV-2 백신의 체액 및 세포 면역원성과 안전성, 관해 또는 낮은 질병 활동도 및 건강한 대조군: 단일 센터 연구

Observational Study

Published on 2022-03-312022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] activity Adenovirus adenovirus-based anti-CD20 therapy anti-RBD anti-RBD neutralizing antibodies antibody Antibody Response Autoimmune AZD1222 BBIBP-CorV BNT162b2 CD4+ T-cell CD4+ T-cell response CD8+ T-cell CD8+ T-cell response cellular center COVID-19 pandemic disease Diseases evaluated Factor FIVE Gam-COVID-Vac healthy control humoral Immunity immunogenic immunogenicity inactivated investigated majority mRNA vaccine mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Musculoskeletal Neutralizing Patient patients positive post vaccination producing proportion Receptor binding domain reduced Remission Rheumatic and musculoskeletal diseases rheumatoid arthritis Safety safety profile SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccination SARS-CoV-2 vaccine single center specific antibody Specific T-cell response T-cell Response TNF-α two-dose regimen vaccination efficacy Vaccine vaccine dose were measured
[DOI] 10.3389/fimmu.2022.846248 PMC 바로가기 [Article Type] Observational Study

Humoral and cellular immunogenicity of SARS-CoV-2 vaccines in chronic lymphocytic leukemia: a prospective cohort study

만성 림프구성 백혈병에서 SARS-CoV-2 백신의 체액 및 세포 면역원성: 전향적 코호트 연구

Clinical Trial

Published on 2022-03-222022-09-11
Journal: Blood advances [Category] MERS, SARS, 변종, 임상, 진단,

[키워드] Absolute lymphocyte count accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody Response Antibody responses assays bead-based multiplex immunoassay binding cellular characterization chronic chronic lymphocytic leukemia clinical benefit CLL CLL patient Cohort coronavirus COVID-19 mortality demonstrated develop dose elicited framework function functional IgG immunoassay induce interferon interferon-γ leukemia lymphocyte Lymphocytic leukemia molecular mechanism molecular mechanisms mRNA-based vaccine outcome Patient Previous studies previous study prospective cohort study provide RBD Receptor binding domain Registered respiratory response rate responses SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine Serologic response serologic responses severe acute respiratory syndrome Coronavirus Spike-specific T-cell responses T-cell T-cell Response T-cell responses tested Therapies therapy treatment-naïve patient treatment-naïve patients Trial vaccination Vaccine variant was performed wild-type
[DOI] 10.1182/bloodadvances.2021006627 PMC 바로가기 [Article Type] Clinical Trial

Persistence of Immune Response in Health Care Workers After Two Doses BNT162b2 in a Longitudinal Observational Study

종단 관찰 연구에서 BNT162b2 2회 투여 후 의료 종사자의 면역 반응 지속

Observational Study

Published on 2022-03-042022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술,

[키워드] age All participants Analysis antibody average binding binding antibody BNT162b2 BNT162b2 vaccine booster dose booster doses booster vaccinations Care cellular Cellular immune response Course COVID-19 disease declining described detectable dose Efficacy evaluated Follow-up groups Health Health care Health care worker hospital humoral humoral and cellular immunity humoral immune response immune response immunological Immunological memory individual interferon Interferon-gamma longitudinal mRNA mRNA-based vaccine Neutralizing antibodies obesity observational study of BNT162b2 Older age participant Participants peptide peptides persistence Pfizer Quantitative response response rate resulting SARS-CoV-2 SARS-COV-2 infection second dose semi-quantitative Serological testing shown vaccination Vaccine worker
[DOI] 10.3389/fimmu.2022.839922 PMC 바로가기 [Article Type] Observational Study

Reactogenicity and immunogenicity of heterologous prime-boost immunization with COVID-19 vaccine

코로나19 백신을 이용한 이종 프라임-부스트 면역의 반응원성과 면역원성

Review

Published on 2022-03-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 변종, 임상,

[키워드] adverse events bioRxiv Cellular immune response Characteristics clinical trial clinical trials Cochrane Library COVID-19 COVID-19 vaccination database delta variant evaluated Evidence Final Heterologous heterologous prime-boost heterologous prime-boost immunization heterologous vaccination regimen heterologous vaccination regimens humoral immune response immunogenic immunogenicity Inactivated vaccine instrument medRxiv mRNA mRNA-based vaccine New observational studies outcome pandemic Prime-boost provided reactogenicity regimen risk Risk of bias robust searched selected Support systemic reactions Systemic review tolerable vaccination Vaccine vaccine administration variant with COVID-19
[DOI] 10.1016/j.biopha.2022.112650 PMC 바로가기 [Article Type] Review

Potency of BNT162b2 and mRNA-1273 vaccine-induced neutralizing antibodies against severe acute respiratory syndrome-CoV-2 variants of concern: A systematic review of in vitro studies

BNT162b2 및 mRNA-1273 백신 유도 중화항체의 중증급성호흡기증후군-CoV-2 변이체에 대한 효능: 시험관 내 연구의 체계적인 검토

Review

Published on 2022-03-012022-09-11
Journal: Reviews in Medical Virology [Category] MERS, SARS, 변종, 진단,

[키워드] (Alpha) (Beta) acute respiratory syndrome addition Alpha antibodies antibody B.1.1.7 B.1.1.7 variant B.1.351 B.1.351 variant B.1.617.2 Beta bioRxiv BNT162b2 CONSORT Delta dose Effectiveness elicited eligibility criteria Emergency use authorization Gamma immune immunized in vitro study individual Live virus medRxiv mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-based vaccine neutralization Neutralization assay neutralized Neutralizing Neutralizing antibodies neutralizing antibody of BNT162b2 P.1 platform potency pseudovirus raised reduced Reporting respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants searched sensitivity sera Standard systematic review titre vaccinated individual vaccinated individuals vaccination variant variants variants of concern viruses was used Web of Science
[DOI] 10.1002/rmv.2277 PMC 바로가기 [Article Type] Review

Neutralizing Antibodies and Cytokines in Breast Milk After Coronavirus Disease 2019 (COVID-19) mRNA Vaccination

Contents

Published on 2022-02-282022-10-28
Journal: Obstetrics and gynecology [Category] COVID-19, COVID19(2023년), SARS,

[키워드] acute respiratory syndrome Anti-RBD antibody anti-RBD IgA Anti-RBD IgG antibody B.1.1.7 B.1.351 Beta Blood Breast breast milk Breastfeeding Cellular immune response cohort study collected controls coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccination Cutoff cytokine D614G domain Dried blood spots driven by enrolled enzyme-linked immunosorbent evaluate expressed first dose Gamma IgG immune response Immunoglobulin Infant Infants interferon-γ lactating women Level milk mother mRNA mRNA-based mRNA-based COVID-19 vaccine mRNA-based vaccine neutralize neutralized neutralizing antibody P.1 passive immunity positive provided RBD reflected SARS-CoV-2 second dose second vaccination Side effects Stool Stool sample tested transfer transferred vaccination Vaccine variant variants of concern were measured were used women
[DOI] 10.1097/AOG.0000000000004661 PMC 바로가기 [Article Type] Contents

SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis Treated with Fingolimod: Protective Humoral Immune Responses May Develop after the Preferred Third Shot

Article

Published on 2022-02-212022-10-28
Journal: Vaccines [Category] COVID-19,