Impact of chemoprophylaxis immunisation under halofantrine (CPS-HF) drug cover in Plasmodium yoelii Swiss mice malaria modelArticle Published on 2022-02-282024-09-10 Journal: Folia Parasitol (Praha) [Category] 말라리아, [키워드] CPS-immunisation Cytokines mRNA expression real time PCR Sporozoites PMC 바로가기
SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron MetabolismSARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다Article Published on 2022-02-182022-09-10 Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc [DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article
Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single PatientMedicine Published on 2022-02-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] alveolar Analysis analyzed AQP3 Basal cell basal cells COVID-19 COVID-19 disease cytokine determine died Diffuse alveolar damage FIVE help identify Immune cell immune cells immunohistochemistry increase in indications Inflammation Inflammatory response lobe lung lung lobe lung lobes moderate mRNA expression pathological pathophysiology pathway Patient patient with COVID-19 profile Protective RNA-sequencing SARS-CoV-2 severe inflammation Site stages tissue Ventilation Viral transmission virus [DOI] 10.3389/fmed.2022.841170 PMC 바로가기 [Article Type] Medicine
A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed [DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology
All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling PathwayImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1 [DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology
Hyperpolarised 13 C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancerArticle Published on 2022-01-242022-10-04 Journal: Nature Communications [Category] 바이오마커, 진단, [키워드] accompanied Cancer Cancer imaging Cancer metabolism cell population changes in clinically Cohort correlated detect disease enzyme epithelial expression identify immunohistochemistry independent indolent Intravenous injection Lactate lactate dehydrogenase LDHA LDHB magnetic resonance imaging measure metabolism MRI mRNA expression observé phenotype Prostate Prostate cancer transcriptomics tumour [DOI] 10.1038/s41467-022-28069-2 PMC 바로가기 [Article Type] Article
Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltrationResearch Paper Published on 2022-01-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] acute respiratory syndrome Algorithms Analysis cellular CIBERSORT clinicopathological parameter coronavirus correlated COVID-19 Cox regression Decreased DNA methylation drug target examined exhibited expression GEO global pandemic GSEA HPA immune Immune cell infiltration immune infiltration investigated KEGG lung cancer lung cancer patient lung cancer patients metabolic pathway molecular function mRNA mRNA expression outcome pathway Patient performed poor prognosis predict predictive power prognostic prognostic biomarker Prognostic value protease protein expression reduced SARS-CoV-2 SARS-CoV-infected cells serine 2 significantly Spread survival therapeutic target TMPRSS2 TMPRSS2 expression transmembrane was determined [DOI] 10.18632/aging.203823 PMC 바로가기 [Article Type] Research Paper
Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'에 대한 논평Comment Published on 2022-01-112022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, [키워드] Analysis analyzed Anticoagulant asthmatic BALF Bronchoalveolar lavage fluid Coagulation coagulation cascade Coagulopathies Comment comparable Complete COVID-19 COVID-19 patient COVID-19 patients data set data sets dataset datasets expression extrinsic Factor FIBRIN fibrinogen fibrinolysis fibrinolytic Gene Expression Human increases in Inflammatory inhibitor Interaction Local Lungs master regulator mechanism Microbiome mRNA expression obese performed protein C reduced remained reported Retrospective analysis RNA-Seq RNA-sequencing SARS-CoV-2 significantly supported suppresse TFPI These data Tissue Factor Transcriptome transcriptomic analysis upregulation [DOI] 10.7554/eLife.74268 PMC 바로가기 [Article Type] Comment
Effects of Weight Loss on Adipose and Muscular Neuropilin 1 mRNA Expression in Obesity: Potential Implication in SARS-CoV-2 Infections?비만에서 지방 및 근육성 뉴로필린 1 mRNA 발현에 대한 체중 감소 효과: SARS-CoV-2 감염에 대한 잠재적 영향?Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Obesity facts [Category] SARS, 비임상, 임상, [키워드] ACE-2 adipose Adipose tissue age animal body mass body mass index body weight breath changes Clamp control group driven by Effect estimate expressed fatty Fatty acid female Follow-up followed by free fatty acid improvement indicate insulin Insulin sensitivity insulin sensitivity index Intervention involved lipid transport liver Loss mRNA mRNA expression neuropilin neuropilin 1 obesity Phenotyping Potential Randomized receptor reduction SARS-CoV-2 Skeletal muscle storage Stratified randomization subject subsequent susceptibility tendency tissue was measured was performed weight weight loss Weight reduction whole body [DOI] 10.1159/000520419 PMC 바로가기 [Article Type] Randomized Controlled Trial
High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 PatientsArticle Published on 2021-12-182022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] analyzed B-cell Biomarker Blood blood cell blood sample CD169 CD8 T-cell clinical outcomes correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 therapy cytokine Cytokine storm disease Disease progression Disruption dose-dependent manner Evidence flow cytometry fluorescence intensity healthy donor Hospitalization IL-10 IL-6 immune dysfunction immunophenotype in vitro Inflammation inflammatory markers lymphocyte marker maturation monocyte mRNA expression mRNA levels outcome overexpressed Patient PBMC Pneumonia Predictive pulmonary involvement Ratio Respiratory outcome SARS-CoV-2 severity sialoadhesin stimulated T-cell exhaustion the median the spike protein Transcription [DOI] 10.3390/pathogens10121639 PMC 바로가기 [Article Type] Article