Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemicSARS-CoV-2의 바이러스학, 역학, 면역학 및 백신 개발, 대유행 9개월 만에 업데이트Meeting Report Published on 2021-01-012022-09-01 Journal: Biologicals : journal of the International Associa [Category] SARS, 신약개발, 임상, 진단, [키워드] Alliance antibody Biological Biological Standardization contribute country COVAX COVID-19 dose Epidemiology Highlights IgA immunology Initially International mucosal immune nasal Neutralizing antibodies nine organized pandemic public health emergency Recombination Saliva SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection second wave the vaccine Transmissibility Vaccine Vaccine development Virology virus [DOI] 10.1016/j.biologicals.2020.11.003 PMC 바로가기 [Article Type] Meeting Report
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 InfectionCOVID-19의 점막 면역: SARS-CoV-2 감염의 무시되지만 중요한 측면Review Published on 2020-11-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] aspect Asymptomatic Cell-mediated immunity circulating COVID-19 diagnostic IgA antibody immune response immune system Immunity immunoglobulin A infect Infection Interaction majority Mild mucosal mucosal immune mucosal immunity mucosal surfaces Neglected occur Prophylactic responses SARS-CoV-2 serum antibody therapeutic upper respiratory tract [DOI] 10.3389/fimmu.2020.611337 PMC 바로가기 [Article Type] Review
The Challenges of Vaccine Development against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine VectorReviews Published on 2020-09-042022-10-30 Journal: Molecular Biology [Category] COVID-19, [키워드] ADE Administered Amino acid Antibody-dependent enhancement antigenic Antiviral approach betacoronaviruses caused Cell-mediated immune responses challenge Combination conformational changes conservative antigenic determinants coronavirus COVID-19 Dependent determinant development effective elicit enhancement expressing glycosylation help humoral Immunity inactivated induce Infection intranasally MERS-CoV mucosal mucosal immune murine respirovirus new SARS-CoV-2 provide respiratory pathogen respiratory tract risk S-protein Safe SARS-CoV-1 SARS-CoV-2 Sendai virus stimulate targeting the spike protein the vaccine Trial Vaccine vaccine vector vector viral infection Viral protein viral vectors virion [DOI] 10.1134/S0026893320060151 PMC 바로가기 [Article Type] Reviews
Immune responses to porcine epidemic diarrhea virus (PEDV) in swine and protection against subsequent infectionResearch Article Published on 2020-04-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] B cell Blood CD4/CD8 Cell cytometry analysis disease epidemic diarrhea evaluated fecal Flow Frequency humoral IgA IgG antibody immune response increase in Infection intestine Lymph node memory T cell MLN mucosal immune PEDV persist positive Prevent PROTECT Re-infection response RNA serum significantly higher significantly increased subsequent T cell understanding virus were infected [DOI] 10.1371/journal.pone.0231723 PMC 바로가기 [Article Type] Research Article
Recombinant Lactococcus Lactis Expressing M1-HA2 Fusion Protein Provides Protective Mucosal Immunity Against H9N2 Avian Influenza Virus in ChickensOriginal Research Published on 2020-03-242023-08-30 Journal: Frontiers in Veterinary Science [Category] E형 간염, [키워드] H9N2 immune responses Lactococcus lactis mucosal immune Oral vaccine [DOI] 10.3389/fvets.2020.00153 PMC 바로가기 [Article Type] Original Research
Oral vitamin A supplementation of porcine epidemic diarrhea virus infected gilts enhances IgA and lactogenic immune protection of nursing pigletsResearch Article Published on 2019-11-292022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Acetate antibody secreting cell boost Cell correlated Critical determine diarrhea ENhance epidemic diarrhea gestation Gut homing IgA IgA antibody immune protection immune system Immunity inoculated intestinal lactation lactogenic lymphocyte mucosal immune oral PEDV pleiotropic effect Pregnancy pregnant RNA serum survival rate virus Vitamin vitamin A [DOI] 10.1186/s13567-019-0719-y PMC 바로가기 [Article Type] Research Article
Development and comparison of enzyme-linked immunosorbent assays based on recombinant trimeric full-length and truncated spike proteins for detecting antibodies against porcine epidemic diarrhea virusResearch Article Published on 2019-11-272022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] antibody caused Cell cell line development disease Efficacy ELISA ELISA kit ELISAs embryonic kidney enzyme-linked immunosorbent assay epidemic diarrhea exhibited expressed expression full-length full-length S Genotype high mortality Human embryonic kidney (HEK)-293 mammalian cell expression system humoral hyperimmune immunization immunostaining Impact indirect ELISA infected cell mucosal immune Neonatal nucleocapsid outbreak PEDV Porcine epidemic diarrhea (PED) Protein Result sensitivity Sensitivity and specificity sera Serological assay serological test serology specificity Spike protein Spike protein specific ELISA trimeric virus was selected [DOI] 10.1186/s12917-019-2171-7 PMC 바로가기 [Article Type] Research Article
Mucosal Immune Response to Feline Enteric Coronavirus InfectionArticle Published on 2019-09-272022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] abnormality biopsy caused collected Colon Control convalescent coronavirus enteric expression fatal disease fecal Fecal sample feline enteric coronavirus Feline infectious peritonitis groups histologic humoral IFNγ IgG Infection inflammatory state investigated lymphocyte subpopulation mucosa mucosal mucosal IgA response mucosal immune mucosal immunity mutant virus organ pathogenic Perturbation phenotype proliferation response Result Significant suggested T cell three groups virus virus clearance [DOI] 10.3390/v11100906 PMC 바로가기 [Article Type] Article
A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in MiceArticle Published on 2019-08-292022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory illness bacterium-like particles binding activity candidate vaccine cellular displaying domain enhancer fusion protein GEM Human humoral immune response infections intestinal tract intranasal administration intranasally Lactococcus linker Local MERS-CoV MERS-CoV RBD mice Middle East motif mucosal mucosal immune New coronavirus novel outbreak Particle Prevent PROTECT Protein raised RBD respiratory syndrome coronavirus response Specific substrate Subunit vaccine systemic tested the RBD Vaccine were used [DOI] 10.3390/v11090799 PMC 바로가기 [Article Type] Article
Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn pigletsResearch Articles Published on 2019-02-262022-10-28 Journal: Bioscience Reports [Category] Coronavirus, MERS, [키워드] administration antibody Antigen B. subtilis Bacillus subtilis candidate vaccine cause CD3 CD4 cells COE Contact contagious demonstrated develop disease effective epidemic diarrhea evaluated expressing IgA IgG immune immune response immunization Immunoglobulin immunoglobulin A Infection Local lymphocyte mucosal mucosal immune mucosal immunity Newborn oral administration Oral vaccine PEDV Peyer’s patche Piglets Porcine epidemic diarrhea virus prevented recombinant Bacillus subtilis responses secreting serum SIgA significantly significantly increased Spread systemic immune response T cells up-regulated Vaccine Vaccines virus [DOI] 10.1042/BSR20182028 PMC 바로가기 [Article Type] Research Articles