Structural and Dynamic Insights into SARS-CoV-2 Spike-Protein-Montmorillonite InteractionsSARS-CoV-2 스파이크-단백질-몬모릴로나이트 상호작용에 대한 구조적 및 동적 통찰력Article Published on 2022-08-022022-09-11 Journal: Langmuir : the ACS journal of surfaces and colloid [Category] COVID19(2023년), SARS, 변종, [키워드] Cell cell entry Critical develop drug drug therapy dynamic effective electrostatic explicit glycan glycans help hydrophobic hydrophobic interaction hydrophobic interactions immune response insight Interaction interactions Ion mechanism Modification molecular dynamics Molecular dynamics simulation Montmorillonite nanoparticle pandemic performed probe Protein provide residue residues S protein SARS-CoV-2 therapeutic therapy Vaccine Vaccine development Vaccines variant virus world population [DOI] 10.1021/acs.langmuir.2c00837 PMC 바로가기 [Article Type] Article
Nanoparticles in clinical trials of COVID-19: An updateReview article Published on 2022-08-012022-10-05 Journal: International journal of surgery (London, England) [Category] 변종, 임상, 치료제, [키워드] approved benefit Bioavailability clinical trial clinical trials COVID-19 COVID-19 disease COVID-19 vaccination drug delivery drugs effective effective vaccine Efficacy Efficiency effort example exhibit globe highlighting Immunity Immunotherapy inaccessible increasingly indication Infectious disease investigated long-lasting medication Medicine Medicines nanoparticle Nanoparticles outbreak outcomes pandemic provide reducing researcher Safe SARS-CoV-2 antigen Strategy therapeutic therapy Toxicity Treatment Vaccine Vaccines WHO World Health Organization [DOI] 10.1016/j.ijsu.2022.106818 [Article Type] Review article
Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trialArticle Published on 2022-07-222022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 approach AS03 cellular immunity CEPI clinical study conducted COVID-19 COVID-19 pandemic deviation displaying distribution dose eligible Emergency use enrolled evaluate evaluated flu vaccine foundation geometric mean concentration group groups healthy hospital Humoral immunity IgG antibody immunogenic immunogenicity injection site pain Intervention intramuscularly Investment Local Melinda Gate mitigate myalgia naïve nanoparticle nanoparticle vaccine neutralizing antibody observer-blinded outcome participant per-protocol phase Placebo placebo-controlled primary immunogenicity Protein protocol pseudovirus randomised RBD RBD IgG reached reactogenicity receive recipient Recombinant protein recombinant protein vaccine Registered reported Safety SARS-CoV-2 SARS-COV-2 infection second dose Stage study enrollment Support supported systemic AE systemic AEs T-cell immune responses the receptor-binding domain the vaccine titre Trial vaccination vaccination schedule Vaccine wild-type virus World Health Organization [DOI] 10.1016/j.eclinm.2022.101569 PMC 바로가기 [Article Type] Article
Modulating Fingolimod (FTY720) Anti-SARS-CoV-2 Activity Using a PLGA-Based Drug Delivery SystemArticle Published on 2022-07-182022-10-04 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 신약개발, [키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activity cell line Combination concentrations confocal microscopy COVID-19 COVID-19 case Cytometry death delivery develop Disease progression drug Drug repurposing encapsulation exhibit fingolimod Flow FTY720 less Lysosomes macropinocytosis nanoparticle Nanotechnology occur pathway PLGA PLGA-based nanoparticles reduce Safe System therapy for COVID-19 Toxicity Treatment Vaccine viral infection Viral transmission [DOI] 10.1021/acsabm.2c00349 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article
Nanoparticles in the diagnosis and treatment of vascular aging and related diseases Reviews Published on 2022-07-112022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] advance adverse effect alteration cardiovascular diseases cellular cellular senescence cerebrovascular diseases chronic kidney diseases Diagnosis diagnostic disease Diseases Epigenetic events function knowledge less limitation mitochondrial dysfunction molecular Multiple nanoparticle Occurrence oxidative stress Phenotypes Prognosis structures therapeutic tissues Treatment Vascular vascular inflammation vasculature [DOI] 10.1038/s41392-022-01082-z [Article Type] Reviews
Antibacterial, Antibiofilm, and Antiviral Farnesol-Containing Nanoparticles Prevent Staphylococcus aureus from Drug Resistance Development항균제, 항생물막 및 항바이러스성 파르네솔 함유 나노입자가 약물 내성 발달로부터 황색포도상구균을 예방합니다Article Published on 2022-07-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] actives addition anti-inflammatory cytokine anti-inflammatory cytokines Antibacterial Antibiotics antimicrobial resistance Antimicrobials antiviral property Bacteria Bacterial bacterial eradication biocompatibility biofilm prevention and elimination Care Community Complete Concentration Cytokines demonstrated development drug drug-resistant Elimination farnesol farnesol nanoparticles. Health Health care increased mortality induce Infection infections inhibit inhibited irritation less microbial morbidity nanoparticle reduced resistance responsible SARS-CoV-2 secretion skin infections skin tissue Spike proteins Staphylococcus aureus Support the spike protein [DOI] 10.3390/ijms23147527 PMC 바로가기 [Article Type] Article
A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 MiceRBD 60-mer 나노입자를 암호화하는 mRNA 백신은 형질전환 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 중화 항체 및 보호 면역을 유발합니다Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against Antigen COVID-19 pandemic Delta delta variant displaying domain effective elicit encoding flexible hACE2 K18-hACE2 messenger Messenger RNA mRNA mRNA vaccine nanoparticle Neutralizing neutralizing antibody Neutralizing antibody response platform protective immunity provide RBD RBDs Receptor binding domain Receptor-binding domain RNA vaccine robust SARS-CoV-2 SARS-CoV-2 variant severe disease Spread the RBD the SARS-CoV-2 Transgenic mouse Vaccine [DOI] 10.3389/fimmu.2022.912898 PMC 바로가기 [Article Type] Article
Ag Nanoparticles with Ultrathin Au Shell-Based Lateral Flow Immunoassay for Colorimetric and SERS Dual-Mode Detection of SARS-CoV-2 IgGSARS-CoV-2 IgG의 비색 및 SERS 이중 모드 검출을 위한 초박형 Au 쉘 기반 측면 유동 면역분석법이 있는 Ag 나노입자Article Published on 2022-06-142022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] antibodies can be used Characteristics coefficient colloidal gold color Concentration conducted detect detection diagnosing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Flow gold growth immune response Immunoglobulin inter-assay variation Lateral lateral flow immunoassay LFIA magnitude nanoparticle optical progression Protein qualitative analysis Quantitative analysis reproducibility SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein sensitivity serum samples significantly specificity Spike protein surface chemistry test strips the SARS-CoV-2 was used [DOI] 10.1021/acs.analchem.2c01286 PMC 바로가기 [Article Type] Article
A Universal Fluorescent Immunochromatography Assay Based on Quantum Dot Nanoparticles for the Rapid Detection of Specific Antibodies against SARS-CoV-2 Nucleocapsid ProteinSARS-CoV-2 뉴클레오캡시드 단백질에 대한 특정 항체의 신속한 검출을 위한 양자점 나노입자 기반 범용 형광 면역크로마토그래피 분석Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody complex Concentration conditions conserved coronavirus coronavirus 2 coupling COVID-19 detection Diagnosis diagnostic Dot expansion expressed Fluorescence fluorescent fluorescent immunochromatography assay Host IgG immunochromatography life cycle limit of detection Mutation rates nanoparticle Ni-NTA nucleocapsid nucleocapsid protein optimization pathogenic point of care point-of-care Point-of-care detection probes Protein protein A purified purity quantum quantum dots Rapid related viruses respiratory respiratory infection SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Specific specific antibodies specific antibody specificity Spike protein Spike proteins susceptible Transmission Universal virus viruses was determined Zoonotic coronavirus zoonotic coronaviruses [DOI] 10.3390/ijms23116225 PMC 바로가기 [Article Type] Article