Natural killer cells – Page 4 – Communicable Diseases Research

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Protocol

Published on 2022-01-252022-10-29
Journal: JMIR Research Protocols [Category] COVID-19,

Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology

가용성 CD24를 사용한 치료는 COVID-19 관련 전신 면역병리를 약화시킵니다

Clinical Trial

Published on 2022-01-102022-09-12
Journal: Journal of Hematology & Oncology [Category] 임상, 진단,

[키워드] acute respiratory syndrome coronavirus Analysis anti-inflammatory agent anti-inflammatory agents Anti-viral Antibody Response approach attenuate binding blunt cause CD24 CD24Fc CD4 CD56 CD8 cellular compartments chemokine chemokines Clinical characteristics Clinical efficacy coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity cytokine Cytokine score Cytokines damage damage-associated molecular pattern Damage-associated molecular patterns demonstrated downstream enrolled epithelial cells Extracellular flow cytometry heat shock proteins homeostasis homology Immune homeostasis immunopathology Immunophenotyping induce infected individuals Inflammatory response Lung epithelial cells Natural killer cells Pathogenesis pathway Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phosphatase placebo group pro-inflammatory cytokine Protein Randomized Release respiratory Result return SARS-CoV-2 SARS-CoV-2-infected individuals severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity shown Siglec10 significantly Soluble CD24 supplementary material systemic cytokine response systemic inflammation T cell T cells therapeutic therapeutic efficacy Treatment Trial with COVID-19
[DOI] 10.1186/s13045-021-01222-y PMC 바로가기 [Article Type] Clinical Trial

T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

북아프리카 COVID-19 환자의 혈액 내 T 세포 수와 IL-6 농도는 심각한 질병 및 사망에 대한 두 가지 독립적인 예후 인자입니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of leukocyte biology [Category] 바이오마커,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition African Analysis B cells Blood CD4+ T cells CD8+ T cell CD8+ T cells characteristic clinician Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cutoff value cytokine cytokine level cytokine levels Cytokines death death group develop disease flow cytometry healthy control healthy controls help high risk IL-10 IL-6 immune parameter immune system independent investigated lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild Mortality multivariate logistic regression multivariate logistic regression analysis natural killer cell Natural killer cells North outcome parameter pathology Patient patients percentage percentages performed Peripheral blood peripheral blood lymphocyte predict Prognosis Prognostic factor receiver operating characteristic respiratory risk ROC ROC curves SARS-CoV2 severe acute respiratory syndrome Coronavirus severe cases severe disease severity severity of illness significant difference significant differences significantly higher statistical difference statistical differences subset survival T cell T cells Th17 Th2 the disease the patient threshold Total two group two groups
[DOI] 10.1002/JLB.4COVA1020-703R PMC 바로가기 [Article Type] Article

Local and systemic responses to SARS-CoV-2 infection in children and adults

소아 및 성인의 SARS-CoV-2 감염에 대한 국소 및 전신 반응

Comparative Study

Published on 2021-12-222022-09-12
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Adults age airway airways analysed Blood Blood samples Cell characterized children COVID-19 Cytotoxic T cell Cytotoxic T cells dendritic cell dendritic cells Depletion Disease progression early infection epithelial epithelial cell Evidence explain healthy healthy control identify immune cells Increases increases in individual individuals Infection interferon interferon response lymphocyte mechanism nasal Natural killer cells paediatric patients patients with COVID-19 populations reduced response restrict viral replication RNA sequencing SARS-CoV-2 SARS-COV-2 infection significantly increased single-cell subpopulation syndrome T cells tracheal transcriptomics viral replication with COVID-19
[DOI] 10.1038/s41586-021-04345-x PMC 바로가기 [Article Type] Comparative Study

Pegylated Interferon-ɑ (IFN-ɑ) Enhances the Inhibitory Effect of Natural Killer Cells on Regulatory T Cells via IFN-γ in Chronic Hepatitis B

Article

Published on 2021-12-012023-06-13
Journal: The Journal of Infectious Diseases [Category] B형 간염,

[키워드] Chronic Hepatitis B IFN-γ immune regulation Natural killer cells regulatory T cells
[DOI] 10.1093/infdis/jiab216

Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA

SARS-CoV-2 RNA에 대해 재검사를 받은 환자의 전사 특성 및 면역 기능 장애

Article

Published on 2021-10-232022-09-10
Journal: Journal of Molecular Cell Biology [Category] Coronavirus, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis caused CD4 CD8 CD8⁺ Characteristics contribute Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated differentiation discharge enrolled expression global public health Health crisis healthy control hospital ID1 IFITM10 Immune cell immune cells immune function immunological characteristics Infection inhibitor interferon low expression marker mechanism mononuclear cells natural killer cell Natural killer cells NK cells Occurrence Pathogenesis Patient patients Peripheral blood Peripheral blood mononuclear cells positive reduced respiratory RTP patients SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus significantly T cell T cells these cell These cells Transcriptome transcriptome sequencing transmembrane protein with COVID-19
[DOI] 10.1093/jmcb/mjab067 PMC 바로가기 [Article Type] Article

Effect of Age on Innate and Adaptive Immunity in Hospitalized COVID-19 Patients

Article

Published on 2021-10-192022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape

Immunology

Published on 2021-10-132022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] aggregation Analysis cDC2 Cell cell types cells cellular changes in contribute coronavirus disease COVID-19 cross talk disease healthy subjects heterogeneity highlight identify IFN-I immune immune cell type immune-remodeling innate immune response Interaction interferon landscape lineages low-density low-density neutrophils lymphoid MDSC mechanism megakaryocyte Monocytes multisystemic Natural killer cells neutrophil observé Patient patient cohort phenotype plasmablast plasmablasts reduction respond response responses robust scRNAseq severe COVID-19 patients severe disease severe infections severity Single-cell RNA sequencing subset type I while
[DOI] 10.3389/fimmu.2021.738073 PMC 바로가기 [Article Type] Immunology

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

생쥐에서 SARS-CoV-2 감염의 실시간 영상은 중화 항체가 최적의 효능을 위해 Fc 기능을 필요로 함을 보여줍니다

Article

Published on 2021-09-142022-09-11
Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] addition Administered antibody applied bioluminescence imaging BLI Brain convalescent COVID-19 death Effect effective Efficacy Fab Fc effector functions Fc function function hACE2 highlight human ACE2 human ACE2 transgenic mice immune protection immunopathology in vivo indicated Infection Inflammatory response Inflammatory responses Interaction intranasally K18-hACE2 mice limit lung Lungs mechanism mice MONITOR Monocytes NAb NAbs nanoluciferase nasal Nasal cavity natural killer natural killer cell Natural killer cells neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils organ Pathogenesis prevented Prophylaxis required resolved reveal SARS-CoV-2 SARS-COV-2 infection subject systemically therapy transgenic treating COVID-19 Treatment virus spread
[DOI] 10.1016/j.immuni.2021.08.015 PMC 바로가기 [Article Type] Article

Hepatitis E Virus Infection—Immune Responses to an Underestimated Global Threat

Review

Published on 2021-09-022023-06-09
Journal: Cells [Category] E형 간염, Fulltext,

[키워드] hepatitis E virus Innate lymphoid cells Natural killer cells natural killer T cells solid organ transplantation T cells
[DOI] 10.3390/cells10092281 PMC 바로가기 [Article Type] Review