Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug CandidateArticle Published on 2021-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acid Action activity acute respiratory syndrome analogue anti-SARS-CoV-2 antiviral activity candidate Candidates carried chlorinated Compound concentrations coronavirus coronavirus disease COVID-19 derivative drug escaped examined global pandemic impair in vitro in vivo inhibitory concentration maslinic acid MERS-CoV mode molecular docking non-toxic Novel coronavirus oleanolic acid SAR SARS-CoV-2 SARS-CoV-2 main protease screened Strong synthetic tested Treatment viral replication [DOI] 10.3390/pathogens10050623 PMC 바로가기 [Article Type] Article
Comparison of Immunological Profiles of SARS-CoV-2 Variants in the COVID-19 Pandemic Trends: An Immunoinformatics ApproachArticle Published on 2021-05-062022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] antigenicity approach B-cell epitope circulating variant Combination combinations concerning COVID-19 COVID-19 cases COVID-19 pandemic COVID-19 severity descendant determine disease disease severity docking Efficacy England epidemiological epidemiological fitness epitope evaluated FIVE GISAID greater Hospital admission Human IEDB immune responses immunogenic profile immunoinformatics immunoinformatics approach immunological parameter increased risk India infection rate less moderate Mortality mutant Mutation NCBI Neutralizing neutralizing capacity non-allergic non-toxic pathogen Probability profile Protein protein sequence recorded reported SARS-CoV-2 SARS-CoV-2 antigenicity SARS-CoV-2 epitope prediction SARS-CoV-2 immunogenicity SARS-CoV-2 variant SARS-CoV-2 variants selected epitope sequence severe disease severity severity of COVID-19 simulation studies South Africa spike gene Spike protein T-cell the SARS-CoV-2 virus the spike protein the vaccine Toxicity translated Transmission USA vaccine modification variant variants Viremia virus Wuhan strain [DOI] 10.3390/antibiotics10050535 PMC 바로가기 [Article Type] Article
Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2Research Article Published on 2021-04-202022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] acute respiratory syndrome allele Antigen antigenicity B-cell beta coronavirus Candidates contagious Coronavirus-2 COVID-19 COVID-19 cases drug epitope Epitopes evaluated highly antigenic HLA identification immune Interaction leukocyte non-allergenic non-toxic pandemic disease peptide Physicochemical properties predicted Predictive Protein public health emergency RdRP RdRp protein RNA RNA-dependent RNA polymerase SARS-CoV-2 specificity stability T-cell T-cell epitope Toxicity Vaccine virus World Health Organization [DOI] 10.1155/2021/6627141 PMC 바로가기 [Article Type] Research Article
Structure-Based Virtual Screening Identifies Multiple Stable Binding Sites at the RecA Domains of SARS-CoV-2 Helicase EnzymeArticle Published on 2021-03-072022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] Analysis approach ATP AutoDock average binding affinity binding energy binding free energy binding site complexes Compound COVID-19 COVID-19 pandemic criteria Critical database demonstrated disease docking domain drug drug-likeness enzyme Helicase metabolism molecular dynamic simulation MPD3 Multiple Nilotinib non-toxic physicochemical phytochemicals plant predict Protein PubChem RecA regulate repeated RNA SARS-CoV-2 SARS-CoV-2 helicase Scientific community screened Screening screening process Simulation study Site Spread STABLE the SARS-CoV-2 therapeutic strategy triangular Virtual screening was performed ZINC database [DOI] 10.3390/molecules26051446 PMC 바로가기 [Article Type] Article
A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19)Review Published on 2021-02-052022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] affecting Anti-viral approach approaches carrier contributing to Coronaviruses COVID-19 Diagnosis diagnostic diagnostic systems effective facilitate Health health emergency limitation management Measures Metallic nanoparticles multifunctional Nanotechnology Nanotheranostics non-toxic Novel coronavirus outbreak over pandemic therapeutic agent Treatment viral infection viral infections [DOI] 10.1186/s42269-021-00487-0 PMC 바로가기 [Article Type] Review
A computational study to disclose potential drugs and vaccine ensemble for COVID-19 conundrumResearch article Published on 2021-02-012022-10-05 Journal: The British journal of oral & maxillofacial surger [Category] 신약개발, [키워드] allele Amino acid analyzed Anti-viral anti-viral drug antigenic average binding binding free energy cellular immune responses characterized complexes Coverage COVID-1 COVID-19 COVID-19 pandemic Critical determinant drug drugs epitope event high affinity highly antigenic humoral immunogenic In vitro studies in vivo Infection interactions Ligand Multi-epitope vaccine non-allergic non-toxic nucleocapsid nucleocapsid (N) protein pandemic virus peptide-based vaccine Perspective physicochemical property prevalent Protein receptor receptors responsible robust SARS-CoV-2 stability supported T cell therapy for COVID-19 Vaccine Vaccine design Vaccines Virtual screening virulent virus virus production β-sheet [DOI] 10.1016/j.molliq.2020.114734 [Article Type] Research article
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro시험관 내 SARS-CoV-2 감염에 대한 락토페린의 보호 효과Article Published on 2021-01-232022-09-10 Journal: Nutrients [Category] MERS, 진단, 치료제, [키워드] analyzed anti-inflammatory cytokine Anti-inflammatory effects Antiviral antiviral immune response antiviral immunity Caco-2 Caco-2 cell Caco-2 cells COVID-19 curative cytokine determined by Effect epithelial cells expression Gene Expression Genes glycoprotein IFNA1 IFNB1 immune immune response immune response gene immunomodulatory immunostaining in vitro in vitro data Infection inhibited intestinal epithelial cell intestinal epithelial cells IRF3 IRF7 lack lactoferrin MAVS moderate non-toxic Plaque assay qRT-PCR Replication SARS-CoV-2 SARS-COV-2 infection significantly Support TLR3 TLR7 treated uninfected virus was determined was performed [DOI] 10.3390/nu13020328 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers펩타이드 결합 모르폴리노 올리고머에 의한 Vero 세포 배양에서 SARS-CoV-2 억제Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 치료제, [키워드] antiviral agent Antiviral agents base-pair candidate Candidates causative agent Cell Cell culture cell cultures cell viability composed Compound COVID-19 Culture development direct-acting evaluated experiment genomic RNA global public health growth infectivity assay inhibition inhibitory effect negative control non-toxic oligomer pathogen peptide Post-infection Quantitative Quantitative RT-PCR random reduce expression reducing Replication replication of SARS-CoV-2 RNA RT-PCR SARS-CoV-2 sequence sequences steric suppress TCID50 the SARS-CoV-2 titre transcription regulatory sequence Treatment uninfected cell uninfected cells Vero Cell VERO-E6 viability Viral viral growth virus was measured [DOI] 10.1093/jac/dkaa460 PMC 바로가기 [Article Type] Article
Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet™ Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory ResponsesMolecular Biosciences Published on 2021-01-072022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] alleviate Anti-inflammatory anti-SARS-CoV-2 therapeutics AutoDock vina blocked combat complex correlated Cys145 docking drugs Dynamics FIVE fraction functional food Health help Hyperinflammatory hyperinflammatory responses IL1β IL6 IL6R indicated Inflammatory cytokine Interaction M pro main protease molecular molecular docking molecular dynamics non-toxic Oleaceae oleuropein olive oil olive secoiridoids Precision predicted Prevent protease receptor Replication residue response RMSD S protein SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike (S) protein stability structures supported the S protein the SARS-CoV-2 therapy TNFR1 TNFα viral disease virtual search [DOI] 10.3389/fmolb.2020.627767 PMC 바로가기 [Article Type] Molecular Biosciences
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and InfectionCell and Developmental Biology Published on 2020-12-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing [DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology