Optimization of VSV-ΔG-spike production process with the Ambr15 system for a SARS-COV-2 vaccineArticle Published on 2022-07-012023-07-08 Journal: Biotechnology and bioengineering [Category] COVID19(2023년), [키워드] Ambr15 system Fibra-Cel optimization Vero cells virus vaccine production. VSV-ΔG-spike vaccine [DOI] 10.1002/bit.28088 PMC 바로가기
Multilevel threshold image segmentation for COVID-19 chest radiography: A framework using horizontal and vertical multiverse optimizationResearch article Published on 2022-07-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, [키워드] Algorithm applied Chest Chest radiography Combination Coronavirus pneumonia COVID-19 COVID-19 diagnosis COVID-19 patient diagnose diagnosed effective Efficiency form help IMPROVE index information less Local Lungs mechanisms Meta-heuristic Multi-threshold image segmentation Multi-verse optimization novel coronavirus pneumonia optimization Patient peak promote Ratio Research signal the patient threshold [DOI] 10.1016/j.compbiomed.2022.105618 [Article Type] Research article
Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSOADESSO를 사용한 신속하고 적응 가능하며 민감한 Cas13 기반 COVID-19 진단Article Published on 2022-06-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted Antigen antigen tests applicability causative agent clinical samples comparable COVID-19 COVID-19 pandemic Critical detect detection diagnose diagnostic diagnostic test diagnostics equipment extracted RNA flexibility helping identify infected individual infected individuals optimization Patient PCR testing point of care Rapid RT-qPCR SARS-CoV-2 sensitivity Sensitivity and specificity Specific Spread strain variant variants [DOI] 10.1038/s41467-022-30862-y PMC 바로가기 [Article Type] Article
Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variantsSARS-CoV-2 변이체의 환자별 분석을 위한 미세유체 플랫폼에서 바이러스 게놈 및 나노 리포솜 엔지니어링Review Published on 2022-06-062022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] (Alpha) (Beta) accelerate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B.1.1.529 B.1.351 B.1.617.2 Beta binding Blood Cell culture Coagulation contributing to Conventional coronavirus COVID-19 COVID-19 pandemic Delta encapsulate Engineering ethical concern ethical concerns genomic sequence glycoprotein highlight host cell host cells Increasing Lambda Microfluidics mutations mutations, variants of concerns nano-liposomes Neutralizing antibodies neutralizing antibody New omicron optimization organ Organ on-a-chip organ-specific pathogenicity persistence platform predict primates Protein recent Reinfection resource respiratory rising SARS-CoV-2 SARS-CoV-2 Spike mutation SARS-CoV-2 spike mutations SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus spike spike glycoprotein spike mutations Spike protein Spread strength the Spike therapeutic target therapeutic targets Therapeutics Transmissibility two-dimensional unmet need vaccination Vaccine variant variants Viral viral genomics viral infection Viral variants [DOI] 10.7150/thno.72339 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Whole-Genome Sequencing by Ion S5 Technology-Challenges, Protocol Optimization and Success Rates for Different StrainsIon S5 기술에 의한 SARS-CoV-2 전체 게놈 시퀀싱 - 다양한 균주에 대한 과제, 프로토콜 최적화 및 성공률Article Published on 2022-06-062022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amplicon arise assigned cDNA Concentration construction COVID-19 COVID-19 pandemic demonstrated diagnostics Effectiveness Emergency genomic data idea immunization Ion less library library preparation lineages Modification molecular Molecular epidemiology mRNA mRNA or viral vector vaccines Mutation Next-generation sequencing NGS optimization Panel Patient Poland produced protocol Public public health emergency Rate Real-time PCR required RT-PCR SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage SARS-CoV-2 sequencing Scientific community Sequencing strain Support Surveillance Thermo Fisher Scientific variant variants variants of concern Viral Viral load Viral RNA Viral vector vaccines whole-genome whole-genome sequencing [DOI] 10.3390/v14061230 PMC 바로가기 [Article Type] Article
A Universal Fluorescent Immunochromatography Assay Based on Quantum Dot Nanoparticles for the Rapid Detection of Specific Antibodies against SARS-CoV-2 Nucleocapsid ProteinSARS-CoV-2 뉴클레오캡시드 단백질에 대한 특정 항체의 신속한 검출을 위한 양자점 나노입자 기반 범용 형광 면역크로마토그래피 분석Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody complex Concentration conditions conserved coronavirus coronavirus 2 coupling COVID-19 detection Diagnosis diagnostic Dot expansion expressed Fluorescence fluorescent fluorescent immunochromatography assay Host IgG immunochromatography life cycle limit of detection Mutation rates nanoparticle Ni-NTA nucleocapsid nucleocapsid protein optimization pathogenic point of care point-of-care Point-of-care detection probes Protein protein A purified purity quantum quantum dots Rapid related viruses respiratory respiratory infection SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Specific specific antibodies specific antibody specificity Spike protein Spike proteins susceptible Transmission Universal virus viruses was determined Zoonotic coronavirus zoonotic coronaviruses [DOI] 10.3390/ijms23116225 PMC 바로가기 [Article Type] Article
Indiscriminate SARS-CoV-2 multivariant detection using magnetic nanoparticle-based electrochemical immunosensing자성 나노입자 기반 전기화학적 면역 센싱을 이용한 무차별 SARS-CoV-2 다변량 검출Article Published on 2022-06-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy Alpha Anti-S1 anti-S2 anti-SARS-CoV-2 antibody antibody cocktail antigen test calibration delta variant Delta variants demonstrated Developing diagnose Diagnosis diagnostic Efficiency electrochemical biosensor Frequency include Indiscriminate infected patient infected patients limit of detection Magnetic nanoparticles mitigate monoclonal monoclonal antibodies monoclonal antibody Mutation nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab specimens nasopharyngeal swabs optimization pandemic performed platform polyclonal polyclonal antibody positive positive sample RT-PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 virus sensitivity specificity Swab tested the SARS-CoV-2 virus variant variants variants of SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123356 PMC 바로가기 [Article Type] Article
The paradigm shift in treatment from Covid-19 to oncology with mRNA vaccinesReview article Published on 2022-06-012022-10-05 Journal: Cancer treatment reviews [Category] COVID19(2023년), SARS, 치료법, [키워드] addition administration Antigen approach Cancer Cancer vaccine circumvent clinical study Combination coronavirus disease COVID-19 Efficacy Ex vivo Immunosuppression indications intranasal intravenous Isolation literature medication mRNA mRNA platform mRNA vaccine mRNA vaccines oncology optimization overcome patients platform Research reveal RNA therapeutic therapy treat Treatment Vaccine Vaccine design Vaccines [DOI] 10.1016/j.ctrv.2022.102405 [Article Type] Review article
Structure-based virtual screening, in silico docking, ADME properties prediction and molecular dynamics studies for the identification of potential inhibitors against SARS-CoV-2 M proSARS-CoV-2 M pro에 대한 잠재적 억제제 식별을 위한 구조 기반 가상 스크리닝, 인실리코 도킹, ADME 특성 예측 및 분자 역학 연구Article Published on 2022-06-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] ADME affected Amino acid amino acid residue Asinex library ASN binding CADD carried caused complex Compound compounds computer Computer aided drug design conformational contagious COVID-19 COVID-19 patients docked docking drug drug candidate drug design druggability enzyme evaluated GLU Health Organization hydrogen Hydrogen bond hydrogen bond interactions identify in silico include Infection inhibitor interactions knocking down Ligand M pro maturation molecular molecular dynamics Molecular dynamics simulation Mortality Mpro protein Mutation optimization pandemic participated pharmacological PHE Protein protein-ligand protein-ligand interaction protein-ligand interactions Replication responsible RMSD RMSF SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 Mpro protein Schrodinger software stability strain therapeutic option these compound these compounds TRP Virtual screening virulent was used World Health Organization [DOI] 10.1007/s11030-021-10298-0 PMC 바로가기 [Article Type] Article
HIV and COVID-19 co-infection: A mathematical model and optimal controlResearch article Published on 2022-05-302022-10-05 Journal: Informatics in Medicine Unlocked [Category] 변종, [키워드] Analysis asymptotic basic reproduction number carried Co-infection controls COVID-19 driven by effective Endemic HIV HIV prevention HIV/AIDS Intervention Local mathematical MATLAB measure Measures opportunistic infection Optimal control optimization reduce significantly South Africa stability synergy Treatment with COVID-19 [DOI] 10.1016/j.imu.2022.100978 [Article Type] Research article