A Mini-Review on Cell Cycle Regulation of Coronavirus InfectionVeterinary Science Published on 2020-11-052022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] antiviral therapies cell cycle arrest coronavirus Coronaviruses cycle cyclin-CDK complex feature host cells Human humans infect infection mechanism mammal mechanism molecular mechanism nucleocapsid protein p53 proliferation promote survival widespread [DOI] 10.3389/fvets.2020.586826 PMC 바로가기 [Article Type] Veterinary Science
DTNA promotes HBV-induced hepatocellular carcinoma progression by activating STAT3 and regulating TGFβ1 and P53 signalingArticle Published on 2020-10-012023-06-13 Journal: Life sciences [Category] B형 간염, [키워드] DTNA HBV HCC Liver cirrhosis p53 STAT3 TGFβ1. [DOI] 10.1016/j.lfs.2020.118029
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patientsReport Published on 2020-08-072022-10-06 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA [DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report
Type III interferons disrupt the lung epithelial barrier upon viral recognitionReport Published on 2020-08-072022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] aberrant immune response acute respiratory syndrome airway Antiviral antiviral immunity bacterial superinfections cause characterized Clinical practice contribute coronavirus coronavirus disease COVID-19 COVID-19 patient Critical critical COVID-19 patient dendritic cell disrupt driving elicit Endemic engage ENhance epithelial Evidence expressed expression functions IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs Immune cell immunopathology increase indicate induce Infection influenza infection Influenza virus inhibiting interfere ISGs Local Lower respiratory tract lung lung epithelial lung epithelium Major mice morbidity Mortality Mounting mucosal surface Necrosis p53 parameter Pathogenesis pathophysiological Patient Peripheral blood produced proinflammatory proliferation respiratory viral infections response responses RNA viruses SARS-CoV-2 Science secreted Severe case severity susceptibility therapeutic thought Transcription Trigger turn Type type I Type I IFN Type III IFN type III interferon viral burden viral infections viral respiratory disease viral respiratory infections Viral RNA viruses [DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report
Rationale for Considering Oral Idasanutlin as a Therapeutic Option for COVID-19 PatientsPharmacology Published on 2020-07-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] antiviral activity COVID-19 Idasanutlin MDM2 new therapeutic approach option oral p53 rationale SARS-CoV-2 [DOI] 10.3389/fphar.2020.01156 PMC 바로가기 [Article Type] Pharmacology
Genome-wide computational prediction of miRNAs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed target genes involved in pulmonary vasculature and antiviral innate immunityOriginal Article Published on 2020-06-012022-10-30 Journal: Molecular Biology Research Communications [Category] COVID-19, [키워드] acute respiratory syndrome analysed Analysis Antiviral Apoptosis BMPR2 cellular components China Community Complete coronavirus COVID-19 EGF etiology Evidence FGF receptor function Gene ontology gene silencing Genome genome sequence help human gene Human genome Innate immunity involved mature miRNA microRNA miRNA outbreak p53 pathway Pathways pre-miRNA pre-miRNAs predict predicted receptor signaling Research retrieved RNA genome RNA viruses SARS-CoV-2 Signaling target target gene Target genes the disease vasculature VEGF signaling virus pathogenesis [DOI] 10.22099/mbrc.2020.36507.1487 PMC 바로가기 [Article Type] Original Article
Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infectionArticle Published on 2019-06-092023-06-03 Journal: Emerging Microbes & Infections [Category] B형 간염, Fulltext, [키워드] antiviral therapy Chronic hepatitis B (CHB) cyclin D1 hepatitis B virus (HBV) infection hepatocyte proliferation p53 S-phase kinase-associated protein 2 (SKP2) sodium taurocholate cotransporting polypeptide (NTCP) [DOI] 10.1080/22221751.2019.1625728 PMC 바로가기 [Article Type] Article
Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013Article Published on 2019-06-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Apoptosis Bornavirus caspase 3 Cytotoxic T cells Encephalitis Germany immunopathology p53 variegated squirrel bornavirus 1 viruses VSBV-1 zoonoses [DOI] 10.3201/eid2506.181082 PMC 바로가기
Butyrate inhibits HBV replication and HBV-induced hepatoma cell proliferation via modulating SIRT-1/Ac-p53 regulatory axisArticle Published on 2019-04-012023-06-19 Journal: Molecular carcinogenesis [Category] B형 간염, [키워드] Anti-viral Butyrate HBV p53 Replication SIRT-1 [DOI] 10.1002/mc.22946
The Telomeric Response to Viral InfectionReview Published on 2017-08-092023-08-29 Journal: Viruses [Category] E형 간염, [키워드] ALT Exosomes IFI16 Innate immunity ND10 p53 PML-NB telomere Terra virus [DOI] 10.3390/v9080218 PMC 바로가기 [Article Type] Review