Gaps in the implementation of COVID-19 mitigation measures could lead to development of new strains of antimicrobial resistant pathogens: Nigerian perspectiveCommentary Published on 2021-09-032022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adopted antibiotic Antibiotic resistance Antibiotics antimicrobial abuse antimicrobial agent Care caused common cold Community complicate conditions COVID-19 COVID-19 mitigation measure cross-sectional survey death development Diagnosis disease Endemic Escalation evaluate Evolution exposure feasible FIVE Gap Government HCWs Health Health care worker health condition illness implementation include increase in individual Intervention lockdown malaria medication microorganism new strain new virus Nigeria non COVID-19 patients pandemic disease pathogen Perspective Prevent Randomly responsible SARS-CoV-2 SARS-CoV-2 virus Secondary infection selected social distancing Spread Symptom Treatment virus Volume with COVID-19 [DOI] 10.11604/pamj.2021.40.12.23274 PMC 바로가기 [Article Type] Commentary
Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitorSARS-CoV-2 주요 프로테아제 억제제로서 Withania somnifera (Ashwagandha)의 생리 활성 분자 식별Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] active site antimalarial drug Antimalarial drugs Antiviral effect approach Ashwagandha binding affinity binding free energy causative agent clinical trials Compound compounds COVID-19 COVID-2019 develop disease Diseases docking docking study drug Drug discovery evaluate exhibited free energy Health Organization highest hydrogen hydrogen-bonding interaction hydrogen-bonding interactions identification indicate inhibitor M pro MD simulation molecular docking nCoV pandemic disease polyprotein polyproteins Practitioner predict protease Protein Replication required SARS-CoV-2 SARS-CoV-2 main protease Scientific community selected stability triggered Vaccine virus Withania somnifera World Health Organization [DOI] 10.1080/07391102.2020.1790425 PMC 바로가기 [Article Type] Article
Hybrid COVID-19 segmentation and recognition framework (HMB-HCF) using deep learning and genetic algorithms딥 러닝 및 유전 알고리즘을 사용한 하이브리드 코로나19 세분화 및 인식 프레임워크(HMB-HCF)Article Published on 2021-09-012022-09-11 Journal: Artificial intelligence in medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] Accuracy Algorithm applicability applied approach AUC classification CNN collected Computer science concerning Convolutional neural network convolutional neural network (CNN) COVID-19 Data augmentation (DA) dataset deep deep learning Deep learning (DL) Diagnosis disease dropout Escalation evaluate experiment generalization Genetic Genetic algorithm Genetic algorithms (GA) highest hybrid Infection learning limit lung Lungs majority mechanism Metrics nine optimization overfitting pandemic disease parameter Precision recall reported transfer Transfer learning (TL). was used [DOI] 10.1016/j.artmed.2021.102156 PMC 바로가기 [Article Type] Article
Infodemic vs. Pandemic Factors Associated to Public Anxiety in the Early Stage of the COVID-19 Outbreak: A Cross-Sectional Study in ChinaPublic Health Published on 2021-08-302022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accompanied Analysis Anxiety Boot cause caused China Chinese collected commercial media conducted coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional distribution division early stage effort Epidemic explain Factor Guidance Health indicated infodemic information information overload media mediation outbreak pandemic pandemic disease Panic Psychological Public public health R 2 Randomly regions regression analysis researcher Stage Statistics suggested urban governance vicarious vicarious trauma WeChat while [DOI] 10.3389/fpubh.2021.723648 PMC 바로가기 [Article Type] Public Health
Activation or exhaustion of CD8 + T cells in patients with COVID-19Review Article Published on 2021-08-192022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, Fulltext, MERS, [키워드] activated Activation addition Analysis CD4 CD8 CD8+ T cell cellular immunity contribute coronavirus disease COVID-19 exhibiting expression function functional gene signature immune Infection inhibitory knowledge memory Neutralizing antibodies pandemic disease Patient patients with COVID-19 phenotype phenotypical protective immune response receptors reported SARS-CoV-2 T cell T-cell T-cell exhaustion upregulation [DOI] 10.1038/s41423-021-00750-4 PMC 바로가기 [Article Type] Review Article
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)Research article Published on 2021-08-012022-10-05 Journal: Computational biology and chemistry [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adaptive molecular evolution Affect Amino acid Analysis coated computational analysis Coronaviridae family coronavirus disease COVID COVID-19 Diagnosis distribution Evolution genomic RNA hemagglutinin highly pathogenic homology Host Hypothesis Likelihood ratio test LRT Markov model Maximum likelihood MERS-CoV molecular motif Mutation Non-synonymous novel Novel coronavirus nucleocapsid protein nucleotide substitutions null hypothesis pandemic disease positive Positive selection Radiation Ratio RdRP reported respiratory tract selected silent single-stranded synonymous Test virulence gene virulence genes virus were used zoonotic [DOI] 10.1016/j.compbiolchem.2021.107532 [Article Type] Research article
Deep Learning Approach for Discovery of In Silico Drugs for Combating COVID-19Research Article Published on 2021-07-202022-10-31 Journal: Journal of Healthcare Engineering [Category] COVID-19, SARS, [키워드] approach binding affinities binding affinity can be used clinical trial combating Compound COVID-19 dataset deep deep learning Diagnosis drug Drug discovery drug target drugs effective ENhance forest genetics greater helping Interaction learning Logistic regression Microscopy molecular pandemic disease Pandemics Protein radiologist Remdesivir required Research responsible Result robust SARS-CoV-2 shown suggested SVM Treatment Vaccines were used [DOI] 10.1155/2021/6668985 PMC 바로가기 [Article Type] Research Article
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutantsArticle Published on 2021-07-202022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] acute respiratory syndrome antibody antibody cocktail caused Coronaviral coronavirus Coronavirus disease 2019 COVID-19 Cryo-electron microscopy Cryoelectron microscopy death effective eliminated epitope epitope mapping evade experiment group involved Measures mice mutant Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic disease Pattern recognition receptors performed provide RBD residue SARS-CoV-2 strain the receptor-binding domain therapeutic Threats variant [DOI] 10.1038/s41421-021-00292-z PMC 바로가기 [Article Type] Article
Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseasesReview Article Published on 2021-07-192022-10-29 Journal: Plant Biotechnology Journal [Category] COVID-19, MERS, SARS, [키워드] Aerosols Affect antibody approach attenuate biologic caused cells communicable diseases Community Contact Coronavirus infection country COVID‐19 death disease Diseases droplet drug Epidemic healthcare Healthcare system HIV/AIDS host immune system human infectious disease hygiene include infected individual Infectious disease Insects International management measure microbial molecular molecular farming outbreak pandemic pandemic disease parasite pathogen plant plant‐made pharmaceuticals platform prevalent protein expression reaction SARS‐CoV‐2 Spread suppress Symptom the disease Traditional treat vaccination Vaccine vector [DOI] 10.1111/pbi.13657 PMC 바로가기 [Article Type] Review Article
Detecting SARS-CoV-2 RNA prone clusters in a municipal wastewater network using fuzzy-Bayesian optimization model to facilitate wastewater-based epidemiology퍼지-베이즈 최적화 모델을 사용하여 폐수 기반 역학을 촉진하는 도시 폐수 네트워크에서 SARS-CoV-2 RNA 경향이 있는 클러스터 감지Article Published on 2021-07-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료제, [키워드] analysed approach Bayesian Bayesian approach Biomarker Biomarkers biosensors can not Cluster Community Comorbidity coronavirus COVID-19 criteria diagnostic diagnostic testing discharged distribution early stage economic growth Epidemiology facilitate faece Faeces fused Fuzzy logic Government health emergency hospital identify individual infected individual information lac limitation lockdown pandemic disease Patient Population population density populations Probability provide quarantine real time reduce Research SARS-CoV-2 RNA Spread spread of COVID-19 Stress USA Vaccine virus virus detection wastewater Wastewater sampling. [DOI] 10.1016/j.scitotenv.2021.146294 PMC 바로가기 [Article Type] Article