Research Progress of Genetic Structure, Pathogenic Mechanism, Clinical Characteristics, and Potential Treatments of Coronavirus Disease 2019Pharmacology Published on 2020-08-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory syndrome Affect angiotensin converting enzyme 2 ARDS binding biogenesis cardiovascular system caused Cell clinical Clinical characteristics Coronavirus disease 2019 Coronavirus-2 COVID-19 Cytokine storm digestive system enzyme global pandemic Infectious disease Injury multiple organ failure pathogenesis of SARS-CoV-2 pathogenic mechanism pathogenic mechanisms Potential Potential treatment Progress receptor Respiratory system resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 Structure syndrome systemic inflammatory response Treatment urinary system [DOI] 10.3389/fphar.2020.01327 PMC 바로가기 [Article Type] Pharmacology
SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile VirusPharmacology Published on 2020-08-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 receptor acting administration angiotensin-converting enzyme 2 receptors Antibiotics Antimalarial drugs Antiretrovirals antiviral activity approach certainty Clinical features convalescent plasma coronavirus coronavirus disease corticoids COVID-19 current therapy drug effective Endocytic pathway endocytosis Epitopes host-virus interaction Hydroxychloroquine identify immune immune response immune system disorders immunosuppressive drug Inflammatory cytokines initial interferons kinase inhibitors Mesenchymal stem cells monoclonal antibodies monoclonal antibody neutralization nucleotide analogue Numerous pandemic pathogenic mechanism pathogenic mechanisms promote Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Side effect similarity Spread stem cells Still therapeutic option therapeutic targets therapy Treatment Trial triggered Vaccine virus [DOI] 10.3389/fphar.2020.01224 PMC 바로가기 [Article Type] Pharmacology
Severe Acute Respiratory Syndrome Coronavirus 2: From Gene Structure to Pathogenic Mechanisms and Potential TherapyMicrobiology Published on 2020-07-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accelerate acute respiratory syndrome cellular and molecular coronavirus coronavirus disease correlation COVID-19 COVID-19 infection drug effective vaccine gene structure global public health imperative information morbidity pathogenesis of COVID-19 pathogenic mechanism pathogenic mechanisms Potential potential therapeutic targets Prevent Protein protein function reduce respiratory respiratory virus SARS-CoV-2 Structure therapeutic drug threat treat triggered Vaccine WHO World Health Organization [DOI] 10.3389/fmicb.2020.01576 PMC 바로가기 [Article Type] Microbiology
Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping?Review Published on 2020-05-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] ACE2 receptor adverse outcome affecting article association Bacterial infection blood-brain barrier cerebrovascular CNS correlation COVID-19 COVID-19 patients COVID-19 virus Critical dysfunction Health identify life-threatening Mild neurological no symptom Novel coronavirus pandemic pathogenic mechanism pathogenic mechanisms pathophysiology Patient positive progression reported researcher respiratory disorders risk factor role SARS-CoV-2 smoker smoking the SARS-CoV-2 virus threat virus [DOI] 10.3390/ijms21113916 PMC 바로가기 [Article Type] Review
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoVCommunication Published on 2020-02-222022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome cause caused clinical feature clinical manifestations coronavirus Coronaviruses COVID-19 Diagnosis disease Epidemiology genomic genomic comparison global health security Human human coronavirus lung outbreak pathogen pathogenic mechanism pathogenic mechanisms Patient Pneumonia proteomic proteomic comparison reported respiratory epithelium Respiratory tract infections SARS-CoV SARS-CoV-2 severe symptom similarity Symptoms Treatment virus virus viruses widespread Wuhan [DOI] 10.3390/v12020244 PMC 바로가기 [Article Type] Communication
Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse geneticsArticle Published on 2016-05-202022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] addressed approach association BAC Biological Cell culture cell line cell lines clone complementary disease disease phenotype emergence epidemic diarrhea function Genetic genetics help highlight identify implication in vitro lack less mitigate modulating nucleocapsid nucleocapsid protein ORF3 Pathogenesis pathogenic mechanisms pathogenicity PEDV Porcine epidemic diarrhea virus question reverse genetics RNA recombination Spike protein the spike protein Vaccine Vaccine development viral life cycle viral tropism virulence virus [DOI] 10.1016/j.virusres.2016.05.003 PMC 바로가기 [Article Type] Article
Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virusReview Published on 2015-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affecting applied Asia Asian Canada caused coronavirus described Diagnosis disease effective vaccine effort epidemic diarrhea Epidemics Europe highlight IMPROVE Infection information Japan knowledge measure Molecular epidemiology morbidity and mortality MOST occurred outbreak Pathogenesis Pathogenesis, Preventive measures pathogenic mechanisms PED, PEDV, Review, Molecular epidemiology, Diagnosis PEDV reported researchers South Korea Spread stimulate Taiwan the disease the United State viral disease virus was determined [DOI] 10.1186/s12985-015-0421-2 PMC 바로가기 [Article Type] Review
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article