PBMC – Page 4 – Communicable Diseases Research

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다

Article

Published on 2022-07-092022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

A Path-Based Analysis of Infected Cell Line and COVID-19 Patient Transcriptome Reveals Novel Potential Targets and Drugs Against SARS-CoV-2

감염된 세포주 및 COVID-19 환자 전사체의 경로 기반 분석을 통해 SARS-CoV-2에 대한 새로운 잠재적 표적 및 약물 공개

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ADCY2 ADSL Against anti-SARS-CoV-2 ATP bemcentinib biological network BUB1 Cell cell line cell lines central gene central genes changes Concordance conivaptan COVID-19 COVID-19 severity curated DEGs DEGs (Differentially Expressed Genes) Differentially expressed genes drug drugs targeting dysregulated e genes G1/S transition Genes greater identify Infection leukocyte leukocyte activation LINE metabolic process Migration MOST network analysis novel OCRL PBK PBMC PBMCs PBMCs (Peripheral Blood Mononuclear Cells) peripheral Peripheral blood Peripheral blood mononuclear cells phthalocyanine Potential reveal SARS-C0V-2 SARS-CoV-2 SARS-COV-2 infection severity target target gene TIAM1 Transcriptome transcriptomic viruses with COVID-19
[DOI] 10.3389/fimmu.2022.918817 PMC 바로가기 [Article Type] Article

Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19

Research article

Published on 2022-07-012022-10-05
Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상,

[키워드] addition amoxicillin Anti-bacterial agents Antibiotics benefit CD4+ CD8+ clarithromycin Clinical effect Co-incubation confounder COVID COVID-19 COVID-19 patients Critical care Critically ill patient Cytokines decrease Effect Ex vivo had no healthy hospital ICU patient IFN-alpha IL-10 IL-2 IL-6 immunomodulation immunomodulatory immunomodulatory properties immunomodulatory property in viral increase in infections intensive care intracellular cytokine investigated lymphocyte Macrolide monocyte no effect PBMC phagocytosis reduction in mortality Result retrospective cohort study SARS-CoV-2 Spike protein stimulated synergistic T cell response TNF-alpha Univariate analysis was performed with COVID-19
[DOI] 10.1016/j.jiac.2022.04.001 [Article Type] Research article

Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro

기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다

Article

Published on 2022-06-282022-09-11
Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used
[DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals

단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제,

[키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus
[DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article

Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes

Research article

Published on 2022-06-242022-10-05
Journal: Heliyon [Category] 바이오마커, 치료기술,

[키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed
[DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article

SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity

SARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다

Article

Published on 2022-06-072022-09-12
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단,

SARS-CoV-2 infection relaxes peripheral B cell tolerance

SARS-CoV-2 감염은 말초 B 세포 내성을 완화합니다

Article

Published on 2022-06-062022-09-12
Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 진단,

Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysis

Research article

Published on 2022-06-022022-10-05
Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발,

[키워드] affected Analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 Therapeutic approach Transcriptome viral replication viral strain virus
[DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article

Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study

고형 종양의 영향을 받는 환자에서 발열성 COVID-19의 발병률 및 면역학적 특징: 전향적 코호트 연구

Article

Published on 2022-05-142022-09-11
Journal: Journal of Translational Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] affected Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 asymptomatic infection asymptomatic patient asymptomatic patients baseline Cancer Cancer center changes in chemokine collected COVID-19 COVID-19 in patient COVID-19 pandemic downregulation evaluated feature First wave General population IgM Immunoglobulin interleukin 6 Italy KEGG mononuclear cell mononuclear cells Nasopharyngeal swab NPs p-values pathway Pathways Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells positive prospective cohort study rationale receptor recruited RNA SARS-CoV-2 SARS-CoV-2 IgM Sequencing Seroconversion seroconversion rate serology Signaling solid cancer subset T-cell receptor tested Transcriptome transcriptome sequencing transcriptomic analysis transcriptomics treated upregulated Viral Viral RNA was performed
[DOI] 10.1186/s12967-022-03429-0 PMC 바로가기 [Article Type] Article