Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection혈장 프로테옴 지문은 SARS-COV-2 감염의 고유성과 임상 결과를 나타냅니다.Observational Study Published on 2021-12-072022-08-31 Journal: Viruses [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] ADM Analysis analyzed assist AUROC cardiovascular disease circulating clinical Clinical management Clinical outcome Comparative Course COVID-19 death determine diagnostics disease emergency department emergency medicine evaluated fatality fingerprint helping Hospital admission Hospitalization hospitalized patient IL-6 Infection Inflammation intensive care Kinetics MCP-3 pathophysiology Patient PD-L1 plasma plasma protein plasma proteins plasma samples Predictive presenting Protein proteome proteomic proteomics proximity extension assay risk prediction SARS-CoV-2 SARS-COV-2 infection Standard of care stratified subsequent supported symptoms of COVID-19 TRAIL translate [DOI] 10.3390/v13122456 PMC 바로가기 [Article Type] Observational Study
Novel Fluorinated Spermine and Small Molecule PEI to Deliver Anti-PD-L1 and Anti-VEGF siRNA for Highly Efficient Tumor TherapyArticle Published on 2021-12-022023-08-29 Journal: Pharmaceutics [Category] E형 간염, [키워드] anti-tumor fluorine modified carrier gene silencing PD-L1 VEGF [DOI] 10.3390/pharmaceutics13122058 PMC 바로가기 [Article Type] Article
A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor ActivitiesOriginal Research Published on 2021-12-022023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] biological activity bispecific antibodies inhibition of cancer growth PD-L1 VEGF [DOI] 10.3389/fimmu.2021.778978 PMC 바로가기 [Article Type] Original Research
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests심각한 적응 면역 억제가 심각한 COVID-19 환자가 음성 바이러스 검사 후에도 ICU에서 퇴원할 수 없는 이유일 수 있음Observational Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] adaptive adaptive immune suppression Adaptive immunity addition analyzed Arm blood sample Blood samples caused Cell changes in classic collected COVID-19 COVID-19 pandemic Critically ill CTLA-4 decreased expression discharged enrolled exhibited expression gene expression profile Gene expression profiles Genes HLA molecules Host ICU immune cells Immune suppression Immunosuppression Inflammatory responses mechanism negative Patient patients PD-1 PD-L1 phenomenon SARS-CoV-2 secondary infections Sepsis severe disease Severe infection severely infected patient suppression Symptom Test transcriptome sequencing Viral [DOI] 10.3389/fimmu.2021.755579 PMC 바로가기 [Article Type] Observational Study
Impaired function and delayed regeneration of dendritic cells in COVID-19코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연Clinical Trial Published on 2021-10-062022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections [DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial
Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure임상 적으로 명백한 신장 질환이없는 COVID-19 환자에서 급성 및 만성 부전이없는 환자에서 면역 학적 활성화의 종 방향 비뇨기 바이오 마커Article Published on 2021-10-042022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation Acute kidney injury Admission affected APACHE Biomarker Blood CCL23 Chronic kidney disease clinical status clinically collected condition correlated COVID-19 Critical cross-sectional cross-sectional study CXCL6 DCN death demise dysfunction EGF ferritin followed by Gender Hospital admission IFNg IgM and IgG IL-12 IL-15 IL-18 IL-2 IL-5 IL-6 immune activation immune response immune system immunological immunology inflammatory markers kidney Kidney disease Kidney function Kidney injury LAG-3 longitudinal marker MCP-1 MCP-3 MMP7 modulate modulating Nephrology Non-survivors Patient patients PD-L1 PGF predicted Probability procalcitonin PTN Serum level Seven Spike protein Steroids trajectory unique urinary Urine Viral viral burden [DOI] 10.1038/s41598-021-99102-5 PMC 바로가기 [Article Type] Article
Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell DysfunctionArticle Published on 2021-10-032022-10-31 Journal: Cells [Category] Coronavirus, MERS, SARS, [키워드] adipocytes adipose adipose-tissue-derived mesenchymal stem cells analyzed ASC blockade conditioned media cytokine secretion cytolytic demonstrated disease expression Human IFNγ IFNγ immune immune dysfunction in vitro increased expression individual individuals inducer Inflammation mechanism mice mononuclear cell obese obesity occur overexpressed PD-1/PD-L1 immune checkpoints PD-L1 reduced SARS-CoV-2 secretion STEM stem cell T cell T cell dysfunction Th1 cell tissue viruses visceral white white adipose tissue [DOI] 10.3390/cells10102645 PMC 바로가기 [Article Type] Article
Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions경증 및 무증상 COVID-19 회복기 조절 기능을 보유한 호중구 하위 집합과 관련된 면역 억제의 장기 엔도타입 제시Immunology Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated addition affecting Analysis anti-CD3 anti-SARS-CoV-2 Asymptomatic Asymptomatic COVID-19 asymptomatic infection autologous Blood Cancer CD8 Cell Complication Concentration convalescent convalescent sera coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 convalescents described disease elevated endotype enrolled expansion FACS function functions GM-CSF granulocyte-macrophage colony stimulating factor (GM-CSF) Granulocytic granulocytic myeloid-derived suppressor cells (PMN-MDSCs) healthy donor IgG immune response Immunosuppression immunosuppressive Infection inhibit long-COVID low-density low-density neutrophils (LDNs) lymphopenia mAb Mild myeloid cell myeloid cells NDN Neutralizing Neutralizing antibodies neutrophil neutrophil dysfunction Neutrophils normal density neutrophils past PCR test PD-L1 positive result present proliferation Propagation Regulatory responsible SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severe lymphopenia significantly higher subpopulation suppressor cells T cell T cells T-cell tendency These cells was used were used Whole blood [DOI] 10.3389/fimmu.2021.748097 PMC 바로가기 [Article Type] Immunology
CD8 + PD-L1 + CXCR3 + polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patientsCD8 + PD-L1 + CXCR3 + 다항식 T 세포 풍부도는 중요한 SARS-COV-2에 감염된 환자의 생존과 관련이 있습니다.Research Article Published on 2021-09-222022-08-31 Journal: JCI Insight [Category] SARS, 바이오마커, 치료법, [키워드] adaptive Adaptive immunity CD4 CD8 Cell circulating control mechanisms COVID-19 Critical CXCR3 CXCR5 Cytometry death Deceased determine effector memory effector T cell effector T cells fatal disease Frequency functional granzyme B HLA-DR Imbalance immunology Increased Infectious disease intensive care involved life-threatening mechanism memory T cell memory T cells outcome patients patients with COVID-19 PD-L1 perforin phenotype phenotypic Population Principal component principal component analysis proportion proportions provide SARS-CoV-2–infected patient separation Stage stem cell survival T cell T cell response T cells Teff Vaccine design Viral viral control viral infection [DOI] 10.1172/jci.insight.151571 PMC 바로가기 [Article Type] Research Article