A Tri-Channel Oxide Transistor Concept for the Rapid Detection of Biomolecules Including the SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질을 포함한 생체 분자의 신속한 검출을 위한 삼중 채널 산화물 트랜지스터 개념Article Published on 2022-01-012022-09-11 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Biomolecule Concentration concentrations concept conditions coronavirus demonstrated detect detection electron mobility electrostatic heterojunction highlighting Including Interaction large-area electronics metal oxide semiconductors Oxide Perturbation physiological Rapid real time receptors required respiratory robust S1 protein SARS-CoV-2 sensor severe acute respiratory syndrome Coronavirus solid-state devices solution solution process spike the SARS-CoV-2 transistor transistors sensors. unique [DOI] 10.1002/adma.202104608 PMC 바로가기 [Article Type] Article
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface420 Published on 2021-12-282022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome age B cells Blood children Coronavirus-2 COVID-19 COVID-19 patients cross-talk Cytokine storm deviation Ebola elicit encodes epithelia epithelial epithelial cell Express Factors fraction gene cluster hallmark healthy children Immune cell immune cells immune dysregulation induce infected with SARS-CoV-2 Inflammatory inflammatory phenotype influenza A initial Interaction interferon lung manifestation monocyte multiorgan failure myeloid cell nonstructural proteins pathogenic viruses Patient Perturbation Pneumonia Protein provide provoke reported SARS-CoV-2 SARS-CoV-2 protein severe COVID-19 severe disease Significance spike systemic inflammation transcriptional transduced virus [DOI] 10.1073/pnas.2116853118 PMC 바로가기 [Article Type] 420
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factorsCOVID-19는 분비된 대사 인자의 조절을 통해 새로운 발병 인슐린 저항성 및 지질 대사 조절 장애를 유발합니다Article Published on 2021-12-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Apelin Cohort complications COVID-19 COVID-19 patient Diseases dysregulation Endocrine system and metabolic diseases expression Glucose HDL-C hyperglycemia induce Infectious diseases insulin insulin resistance investigated isobutyric acid lipid metabolism lipids mechanism mechanisms metabolic factor metabolism modulated myeloperoxidase myostatin patients Perturbation Potential biomarker potential biomarkers potential therapeutic target potential therapeutic targets propionic acid Regulation reported REST resulting SARS-COV-2 infection secreted transcription factor transcriptional level [DOI] 10.1038/s41392-021-00822-x PMC 바로가기 [Article Type] Article
Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology
A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations유전 및 약물 교란을 탐색하기 위한 3D 구조 SARS-CoV-2-인간 상호작용체Article Published on 2021-12-012022-09-11 Journal: Nature methods [Category] SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] binding affinity candidate carried changes in COVID-19 pandemic downstream driven by emergence enrichment etiology Evolution facilitate followed by Genetic Host human population hypothese Interaction interface Meta-analysis molecular docking new viral agent new viral agents performed Perturbation predict predicted receptor ACE2 resource SARS-CoV-1 SARS-CoV-2 sequence Spike protein targets the spike protein Transmission variant Viral protein Viral proteins virulence [DOI] 10.1038/s41592-021-01318-w PMC 바로가기 [Article Type] Article
A fresh look at coronary microembolization Reviews Published on 2021-11-162022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] accompanied acute coronary syndromes antiplatelet atherosclerotic plaque benefit circulation Clinical studies clinical trial contractile contribute Coronary drug dysfunction Endothelial dysfunction facilitate feature incidence increase in induce Inflammatory inflammatory reaction Mechanical mechanism Myocardial Myocardial infarction patchy Percutaneous coronary intervention Perturbation physical review rupture Stress thrombotic Treatment vasoconstriction [DOI] 10.1038/s41569-021-00632-2 [Article Type] Reviews
Machine learning and network medicine approaches for drug repositioning for COVID-19Article Published on 2021-11-092022-10-04 Journal: Patterns [Category] 신약개발, 치료제, [키워드] Abstract Algorithm antiviral drugs approach broad-spectrum antiviral broad-spectrum antivirals cellular processe Clinical use compassionate use complementary connectivity COVID-19 developmental drug Drug repurposing Effectiveness experiment explorer Factors FDA-approved drug graph graph visualization Host host protein hypothese Hypothesis IMPROVE include indicated induce information kernels on graphs machine machine learning approach Map methodology network medicine non-negative matrix factorization online tool Perturbation pharmacological predict predicted Protein reduced SARS- CoV-2 SARS-CoV-2 significantly transcriptomics Treatment viral disease while [DOI] 10.1016/j.patter.2021.100396 PMC 바로가기 [Article Type] Article
Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathwaysNF-kB 및 JAK/STAT 신호 전달 경로와 관련된 COVID-19 염증 과정에 관여하는 microRNA의 예측 및 분석Review Published on 2021-11-012022-09-11 Journal: International immunopharmacology [Category] SARS, 유전자 메커니즘, [키워드] activated Acute inflammation Analysis approved Cityscape connection contribute COVID-19 COVID-19 complications COVID-19 disease COVID-19 patient Critical Diseases Evidence exacerbate feature Host Inflammation Inflammatory inflammatory gene inflammatory genes inflammatory pathway inflammatory pathways inflammatory process Inflammatory response Inflammatory responses Interaction involved JAK-STAT signaling pathway JAK/STAT JAK/STAT signaling pathway manifestation microRNA miR-214 miR-223 miR-9 miRNA miRNAs mitigate morbidity and mortality NF-kB non-coding RNA Non-coding RNAs pandemic pathophysiological mechanism pathway Perturbation perturbations prediction Previous studies previous study Regulation STAT target target gene Target genes therapeutic target therapeutic targets virus [DOI] 10.1016/j.intimp.2021.108071 PMC 바로가기 [Article Type] Review
Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report전격성 H1N1 및 중증급성호흡기증후군 코로나바이러스-2 감염, 4년 간격으로 뚜렷한 근본 원인 없이: 증례 보고Case Reports Published on 2021-10-082022-09-10 Journal: Journal of Medical Case Reports [Category] MERS, SARS, 변종, 신종인플루엔자, [키워드] acute kidney acute respiratory syndrome Admission age Analysis Antiviral asymptomatic infection autoantibody Case report challenge clinical picture clinical recovery Comorbidity contributing to Coronavirus-2 Course COVID-19 demonstrated disease disease-causing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Exome expression Factor fulminant genetic change Genetic changes genetic defect genetic defects Genetic variant genetic variants H1N1 H1N1 influenza healthy ICU immune immunological impairment indicate Infection infections Influenza intensive care intensive care unit admission interferon Interferon (INF) interferon pathway interferon response interferon-stimulated gene mechanical ventilation mononuclear cell mononuclear cells Pathways Patient Peripheral blood Perturbation reduced respiratory risk factor Risk factors SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity suffered susceptibility the interferon the patient triggered type I Variation Viral viral infection viral infections virus infection [DOI] 10.1186/s13256-021-03113-9 PMC 바로가기 [Article Type] Case Reports
Confronting false discoveries in single-cell differential expressionArticle Published on 2021-09-282022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, [키워드] absence biological replicates Computational biology and bioinformatics differential expression Differential expression analysis differentially expressed gene Differentially expressed genes disease dissect Functional genomics Gene expression analysis identify Perturbation perturbations response single-cell Spinal cord injury statistical Statistics transcriptomics trauma Variation while [DOI] 10.1038/s41467-021-25960-2 PMC 바로가기 [Article Type] Article