COVID-19 Vaccination-Induced Myopericarditis: An Imager’s PerspectiveCase report Published on 2022-05-012022-10-05 Journal: CJC Open [Category] 바이오마커, [키워드] adverse event age benefit Biomarker Cardiac imaging case sery Chest Clinical course Cohort COVID-19 COVID-19 vaccine dose Evidence individuals with COVID-19 magnetic resonance imaging male median myocarditis noninvasive occurred pandemic patients positive preserved risk vaccination [DOI] 10.1016/j.cjco.2022.01.007 [Article Type] Case report
Evaluating the role of transthoracic echocardiography in hospitalised patients with COVID-19 infectionObservational Study Published on 2022-05-012022-10-04 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome Admission adverse outcome analysed association cardiovascular risk case fatality ratio Cohort cohort study coronavirus COVID-19 COVID-19 pandemic demonstrated diagnostic Diagnostic imaging dysfunction Echocardiogram echocardiographic echocardiography Ejection fraction elevated eligibility criteria Evaluating exploratory feature Features hospital hospitalised hospitalised patient hypertension identify Infection inpatient admission intensive care investigated Mortality myocardial injury myocarditis n=36 non-survivor outcomes parameter Patient PCR polymerase chain positive patient preserved raised retrospective RV dysfunction SARS-CoV-2 significantly troponin levels TTE ventricular virus was performed with COVID-19 [DOI] 10.1136/openhrt-2021-001854 PMC 바로가기 [Article Type] Observational Study
Impact of SARS-CoV-2 Mutations on PCR Assay Sequence AlignmentSARS-CoV-2 돌연변이가 PCR 분석 시퀀스 정렬에 미치는 영향Article Published on 2022-04-282022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] alignment Analysis analyzed assays biosurveillance blind Chain Reaction clinical samples COVID-19 creating diagnosis of COVID-19 diagnostic diagnostics dominant Evidence evidence of failure False negative false negatives functional consequence functional consequences Genome genomic RNA growth highlight identify Impact in silico in viral molecular test Molecular tests Mutation mutations occurred pandemic PCR PCR assay PCR assays polymerase chain polymerase chain reaction preserved proportion Real-time monitoring Real-Time Reverse Transcription Polymerase Chain Reaction Region reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 sequences Sensitivity and specificity sequence sequence identity Sequencing signature statistically sustained therapeutic unique Vaccine variant Viral viral genomes whole genome whole genome sequence Whole genome sequencing [DOI] 10.3389/fpubh.2022.889973 PMC 바로가기 [Article Type] Article
The SGLT2 inhibitor canagliflozin in heart failure: the CHIEF-HF remote, patient-centered randomized trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Nature Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] 95% confidence interval benefit city clinical trial clinical trials conducted diabete diabetes double-blind trial Effect Ejection fraction heart failure IMPROVE inhibitor Interaction pandemic participant Patient Placebo preserved Primary outcome Randomized randomized trial reduced score shifting significantly Sponsor Symptom symptom burden the primary endpoint Total Trial TSS unblinding [DOI] 10.1038/s41591-022-01703-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Six-month humoral response to mRNA SARS-CoV-2 vaccination in patients with multiple sclerosis treated with ocrelizumab and fingolimodocrelizumab 및 fingolimod로 치료받은 다발성 경화증 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 6개월 체액 반응Article Published on 2022-04-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] age analysed Analysis Antibody Units baseline BAU binding antibody unit binding antibody units BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine Clinical data collected correlation COVID-19 disease each time-point Efficacy elapsed expressed fingolimod first dose HCs healthy control humoral Humoral response IgG IgG antibodies IgG antibody immunological characteristics investigated long term Long term humoral response lymphocyte Lymphocyte count mounted mRNA mRNA vaccine Multiple multiple sclerosis NAb NAbs neutralizing antibody Ocrelizumab Patient positive positive correlation positive response preserved Quantitative receiving SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 trimeric spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines sera serum sample serum samples significantly higher Spearman correlation coefficient Spike protein tested the disease the SARS-CoV-2 therapy titre treated Treatment Trimeric spike protein vaccination Vaccine weakened were assessed [DOI] 10.1016/j.msard.2022.103724 PMC 바로가기 [Article Type] Article
Comparison of COVID-19 and non-COVID-19 papersResearch article Published on 2022-04-012022-10-05 Journal: Gaceta sanitaria [Category] 치료기술, [키워드] 95% confidence interval case-control studies case-control study category Characteristics citation conducted Control COVID-19 Evidence FIVE generate identify journal likelihood logistic regression model Non-COVID-19 objective observational study Odds ratio pandemic preserved Probability report Research Ethics Result Sample size SARS-CoV-2 selected variable [DOI] 10.1016/j.gaceta.2022.03.006 [Article Type] Research article
Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences Research Published on 2022-03-252022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 진단, 치료제, [키워드] applicability base bases canonical Cas9 complexes CRISPR degenerate DNA sequence Effects gene sequence Genetic guide guide RNA guide RNAs highlight HIV human gene Inclusion Organisms pathogen Polymorphisms preserved probe protease RNA sequence Single nucleotide polymorphism SNP SNPs spacer specificity variant variety while [DOI] 10.1038/s41467-022-29202-x [Article Type] Research
Long-Term Preservation of SARS-CoV-2 RNA in Silk for Downstream RT-PCR Tests다운스트림 RT-PCR 테스트를 위한 실크에서 SARS-CoV-2 RNA의 장기 보존Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition ambient assays can be used Chain Reaction circumvent cold chain component Control coronavirus determined by diagnostic distribution eliminating inactivated limit limits Limits of detection mechanism Nuclease nuclease-free water offer pathogen Pathogens PCR assays polymerase chain polymerase chain reaction positive controls preservation preserved primer probe reaction reference standard reverse transcription reverse transcription polymerase chain reaction RNA room temperature RT-PCR RT-PCR reaction RT-PCR reactions SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RT-PCR severe acute respiratory syndrome Coronavirus Silk silk fibroin stability storage targets temperature Test the SARS-CoV-2 water without affecting [DOI] 10.1021/acs.analchem.2c00169 PMC 바로가기 [Article Type] Article
Omicron variant Spike-specific antibody binding and Fc activity is preserved in recipients of mRNA or inactivated COVID-19 vaccinesResearch Article Published on 2022-03-152022-10-04 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] accompanied activating addition antibodies antibody Antibody binding binding binding antibody BNT162b2 Cell clearance Compromised contribute CoronaVac COVID-19 vaccine cross death rate description disease effector mechanisms elicited evade exhibited FcγR FcγR2a Fcγr3a full-length functions IgA IgG IgM immune mechanism inactivated individual Infection maintain mechanisms mRNA mRNA vaccines mRNA-1273 natural killer neutralization Neutralizing neutralizing antibody omicron Pathogens populations preserved PROTECT Protein RBD RBD binding IgG receiving receptor recipient reduced SARS-CoV-2 vaccines SARS-CoV-2-specific antibody severe disease shown spike Spread vaccination Vaccine vaccine-induced antibody Vaccines variant variant of SARS-CoV-2 virus Virus neutralization [DOI] 10.1126/scitranslmed.abn9243 PMC 바로가기 [Article Type] Research Article
Cardiopulmonary Exercise Performance and Endothelial Function in Convalescent COVID-19 PatientsArticle Published on 2022-03-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Analysis association cardiopulmonary exercise testing cardiovascular diseases chronic disease circulation coronavirus disease correlation COVID-19 disability dysfunction Efficiency end-tidal endothelial Endothelial dysfunction endothelial function exercise Exercise capacity exhibited function independent Linear regressions manifestation mechanism occupational medicine outcome parameters pathogenic Patient performance pharmacological preserved reduced rehabilitation reported SARS-CoV-2 significantly higher significantly lower standardized protocols study population survivor Survivors tension therapeutic option ventilatory [DOI] 10.3390/jcm11051452 PMC 바로가기 [Article Type] Article