Effectiveness and Cost-Effectiveness of Inactivated Vaccine to Address COVID-19 Pandemic in China: Evidence From Randomized Control Trials and Real-World Studies중국의 코로나19 팬데믹에 대처하기 위한 비활성화 백신의 효과 및 비용 효율성: 무작위 대조 시험 및 실제 연구의 증거Meta-Analysis Published on 2022-07-192022-09-11 Journal: Frontiers in Public Health [Category] 임상, [키워드] 95% CI address Analysis BBIBP-CorV China Chinese clinical trial CNKI combating Control CoronaVac cost-effectiveness COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine death determine effective Effectiveness Efficacy Evidence Factor Hospitalization hospitalizations ICU admission ICU admissions immunization inactivated Inactivated COVID-19 vaccine Inactivated vaccine Inactivated Vaccines infections International Medical cost Meta-analysis Perspective prevented Probability RCT Real-world evidence Result robust robustness sensitivity analysis the vaccine vaccination Vaccine vaccine efficacy was performed Web of Science website were used [DOI] 10.3389/fpubh.2022.917732 PMC 바로가기 [Article Type] Meta-Analysis
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral ActivitySec61 억제제 아프라톡신 S4는 SARS-CoV-2를 강력하게 억제하고 광범위한 항바이러스 활성을 나타냅니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] activity anticancer Antiviral antiviral activities antiviral activity blocked broad-spectrum antivirals cellular characterization COVID-19 Dengue dengue virus double-membrane vesicles dsRNA elicit Endoplasmic reticulum high potency Host host-directed therapeutics. human cells impacted in vitro in vivo Influenza influenza A influenza A virus inhibited inhibitor Microscopy Nile Pandemics Prevent prevented Protein Proteins reduced SARS-CoV-2 Sec61 shown Spike protein tested the spike protein translocation transmission electron microscopy vesicles Viral viral infection Viral protein viral replication virus West Zika [DOI] 10.1021/acsinfecdis.2c00008 PMC 바로가기 [Article Type] Article
The effect of COVID certificates on vaccine uptake, health outcomes, and the economy Research Published on 2022-07-082022-10-05 Journal: Nature Communications [Category] 치료법, [키워드] 95% CI country COVID COVID-19 pandemic death diffusion estimates France GDP Germany Health intensive care Italy lockdown negative test outcomes prevented required total population vaccination Vaccine [DOI] 10.1038/s41467-022-31394-1 [Article Type] Research
Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-07-052022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] 1:1 active against addition age Analysis assigned B.1.1.529 baseline Community Complete COVID-19 COVID-19 symptom COVID-19 vaccination COVID-19 vaccine death diagnostic dose double-blind drugs Efficacy Endpoint expected finding follow-up period funding Health healthy Hoffmann-La Roche hospitalised household contact immune response incidence infected individuals Infectious diseases investigator Local monoclonal antibody combination mounted occurred participant patient population Placebo placebo-controlled trial post-hoc post-hoc analysis prespecified analysis prevented prevention of COVID-19 Prophylaxis proportion provided randomisation randomised Randomly receive receiving reduced Regeneron Pharmaceuticals Registered reported risk of COVID-19 risk reduction Romania RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual Seroconversion seronegative seropositive shown single dose strain stratified subcutaneous injection susceptible symptomatic SARS-CoV-2 infection the placebo group timepoint treatment-emergent adverse event treatment-emergent adverse events uninfected unmet need USA variants waned [DOI] 10.1016/S1473-3099(22)00416-9 [Article Type] Randomized Controlled Trial
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Omicron BA.1 및 BA.2에 효과적인 강력한 인간 SARS-CoV-2 중화 IgA 및 IgG 항체Article Published on 2022-07-042022-09-11 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] animal models antibody Antibody Response Antibody responses Antiviral B-cell boost breadth candidate Cell cellular contribute convalescent COVID-19 demonstrated Diversity effective effector elicited functions Humoral immunity IgA IgA antibodies IgA antibody IgG antibodies IgG antibody immune protection memory B memory B cell memory B-cell monoclonal antibody mucosal tissue mucosal tissues Neutralizing omicron potent prevented provided Receptor-binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serological severe COVID-19 Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic efficacy Treatment Wuhan [DOI] 10.1084/jem.20220638 PMC 바로가기 [Article Type] Article
Case Report of COVID-19 Infection After Kidney Transplant Treated With Casirivimab-Imdevimab and Mycophenolate Mofetil Changed to EverolimusArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 진단, [키워드] addition Administered administration approved cause changed Chemotherapy Clinical course COVID-19 COVID-19 infection diagnosed Donor effective Everolimus expected facilitate Hospitalization Hospitalized Infection inhibited inhibiting Japan kidney transplant knowledge Methylprednisolone Mild moderate monoclonal antibody mother mycophenolate Patient Prevent prevented regimen rejection remained renal function Replication report SARS-CoV-2 serum creatinine Spread suggested the patient therapy Transplant treat treated Treatment virus worsening [DOI] 10.1016/j.transproceed.2021.12.018 PMC 바로가기
Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 미량 수준을 검출하기 위한 표면 강화 공명 라만 산란 기능이 있는 면역 분석 플랫폼Article Published on 2022-07-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation antibody coated with comparable Concentration conjugation Conjugation in gold nanoparticles coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease early diagnosis genetic material gold Gold nanoparticle immunoassay lack limit of detection lowest Methylene Methylene blue multidimensional onset of symptoms plasma platform prevented Protein Resonant Raman molecules SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein detection scattering SERRS immunoassay Platform silica Silica shell functionalization. Spike protein Support the immunoassay Viral proteins [DOI] 10.1016/j.talanta.2022.123381 PMC 바로가기 [Article Type] Article
COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection혈액 투석실에서 예방 접종을 받은 환자의 COVID-19 발생: 감염으로부터 보호하는 지표로서의 항체 역가Article Published on 2022-06-232022-09-11 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant anti-S anti-S IgG Anti-spike Antibody titre BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Casirivimab cause Clinical data Combination confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 outbreak dialysis dialysis room Haemodialysis humoral Humoral response identify IgG Imdevimab immune correlate immune correlates Immunoglobulin Immunoglobulin G Immunosuppression increased risk Infection interquartile range IQR marker monoclonal antibodies monoclonal antibody mRNA vaccination multivariable analysis neutralization Odds ratio outbreak Patient patients prevented recorded reduced respiratory SARS-CoV-2 SARS-COV-2 infection serological response severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe disease the patient titre treated uninfected vaccination Vaccines variant were infected with COVID-19 [DOI] 10.1093/ndt/gfac016 PMC 바로가기 [Article Type] Article
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo조작된 ACE2 미끼는 SARS-CoV-2 Omicron 변이체를 중화하고 생체 내 감염으로부터 보호합니다.Article Published on 2022-06-222022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 Alpha alpha and delta variants Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 BNT162b2 breakthrough infections Casirivimab chimeric Complete conserved conserved region contributed convalescent serum deep delta variant Delta variants demonstrated dose drugs effective enzyme escape escaped evade exhibited Frequency hamster hamsters human ACE2 Imdevimab immunized in vivo individual Infection multiple mutation multiple mutations Mutation N-terminal domain neutralization neutralization titer neutralize neutralized of BNT162b2 omicron parental prevented pseudo-virus raising Receptor binding domain sarbecovirus SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum serum sample serum samples Sotrovimab Spike protein Spike proteins target the SARS-CoV-2 the spike protein theory therapeutic therapeutic antibodies therapeutic effect transgenic mice vaccination Vaccines variant variants Viral viral mutation virus virus-neutralizing Wuhan strain [DOI] 10.1126/scitranslmed.abn7737 PMC 바로가기 [Article Type] Article
Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation Research Published on 2022-06-222022-10-05 Journal: Acta pharmacologica Sinica [Category] 바이오마커, [키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4 [DOI] 10.1038/s41401-022-00933-3 [Article Type] Research