CoVaccine HT™ Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 ImmunizationCoVaccine HT™ 보조제는 재조합 SARS-CoV-2 스파이크 S1 면역화에 대한 강력한 면역 반응을 강화합니다Immunology Published on 2020-10-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] addition adjuvant Affinity maturation Cell-mediated immunity claimed Combination contagious COVID-19 COVID-19 pandemic develop Efficacy elicited facilitated global effort greater IgG immunogenicity induce neutralizing antibody titres Protective protective immune response Protein protein subunit vaccine rapid response recombinant recombinant subunit respiratory virus response S1 domain SARS-CoV-2 SARS-CoV-2 vaccine single dose spike switching titre Vaccine virus [DOI] 10.3389/fimmu.2020.599587 PMC 바로가기 [Article Type] Immunology
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational developmentResearch paper Published on 2020-04-022022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV agonists antibody antigen-specific antibody building characteristic clinical development clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 disease COVID-19 vaccines develop Diseases domain effort elicited ELISA evidenced finding fused Health immune immune response immunization immunogenicity in vivo induce infectious agent injection long-lasting MERS MERS-CoV MERS-CoV S1 MERS-CoV vaccine MERS-CoV vaccines mice Microneedle microneedle array Middle East MNA MOST Novel coronavirus Outbreaks Pandemics produced Progressive Protein protein subunit vaccine respiratory response responses SARS-CoV SARS-CoV-2 SARS-CoV-2 S1 sequence serum specific IgG antibody subcutaneously Subunit vaccine subunit vaccines Support tested the SARS-CoV-2 TLR4 TLR5 translational trimeric trimerization Vaccine variant viral envelope virus virus neutralization assays [DOI] 10.1016/j.ebiom.2020.102743 PMC 바로가기 [Article Type] Research paper
Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and AlpacasArticle Published on 2019-03-022022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] alpaca Camel Camels Complete disease Dromedary effective human infections humans humoral immune response interruption Lower MERS-CoV Middle East naïve nasal turbinate Neutralizing one health outbreak protection protein subunit vaccine reduce reduced respiratory risk robust Serum neutralizing antibody significantly spike These data upper airway vaccination Vaccines viral shedding zoonotic zoonotic transmission [DOI] 10.3390/v11030212 PMC 바로가기 [Article Type] Article