Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets항-SARS-CoV-2 스파이크 IgG의 비정상적인 글리코실화는 혈소판에 대한 전혈전성 자극입니다Article Published on 2021-10-212022-09-12 Journal: Blood [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome adaptive anti-SARS-CoV-2 Anti-spike antibody cause contribute coronavirus coronavirus disease COVID-19 Critical Critically ill dependent on domain Evidence excessive immune response glycosylation immune complex Immunity Immunoglobulin in vitro inhibit kinase P2Y12 pathogenic Patient Platelet platelet activation prothrombotic respiratory problem SARS-CoV-2 spike protein severe COVID-19 severely ill patient small molecule spike IgG subset susceptible the timing therapeutic thrombosis tyrosine von Willebrand factor with COVID-19 [DOI] 10.1182/blood.2021011871 PMC 바로가기 [Article Type] Article
Cerebral Venous Sinus Thrombosis, Pulmonary Embolism, and Thrombocytopenia After COVID-19 Vaccination in a Taiwanese Man: A Case Report and Literature ReviewNeurology Published on 2021-09-242022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] accompanied antibody Anticoagulants Autoimmune diseases cerebral cerebral venous sinus thrombosis correlation COVID-19 D-dimer D-dimer levels diagnosed Diagnosis disease dural sinus thrombosis elevated Embolism Emergency fatal complication headache high mortality rate High-dose immune Immune-mediated Immunoglobulin initiated Intravenous immunoglobulin Laboratory literature male nausea neurologic Neurological deficit Patient physician Platelet positive presenting prothrombotic protocol pulmonary Pulmonary embolism report review Sinus steroid Steroids thrombocytopenia thrombotic treated Treatment vaccination vaccine-induced immune thrombotic thrombocytopenia vomiting worsening [DOI] 10.3389/fneur.2021.738329 PMC 바로가기 [Article Type] Neurology
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19자체 유지 IL-8 루프는 심각한 COVID-19에서 전혈전성 호중구 표현형을 유도합니다Research Article Published on 2021-09-222022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome Analysis ARDS attenuate autocrine cascade characterized Coagulation complement Complement cascade contribute contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical CXCL8 Cytokines Defense degranulation dissect dysregulation functional highlighting identify IL-8 immune response immune responses immunopathology in vitro in vivo Infection initiate interfere intrinsic Lung injury mechanism mice NET NETosis neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogens Patient patients phenotype positive feedback positive feedback loop procoagulant progression proinflammatory proteomics prothrombotic pulmonary microthrombosis recent reduce respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection self-damage severe acute respiratory distress syndrome severe COVID-19 severe SARS severe SARS-CoV-2 Signaling syndrome systemic targeting therapeutic target transcriptomic transition TRAP Vascular Biology vicious cycle [DOI] 10.1172/jci.insight.150862 PMC 바로가기 [Article Type] Research Article
Pathophysiology of Vaccine-Induced Prothrombotic Immune Thrombocytopenia (VIPIT) and Vaccine-Induced Thrombocytopenic Thrombosis (VITT) and Their Diagnostic Approach in EmergencyBrief Report Published on 2021-09-222022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] anti-SARS-CoV-2 vaccine Asia Bacteria country COVID-19 develop diffusion Emergency Hospitalization Immune thrombocytopenia involved Lung injury mechanism morbidity pandemic Pathogenesis Protective prothrombotic question raise reduce reported SARS-CoV-2 severe pneumonia therapeutic strategy thrombocytopenia thrombosis vaccination Vaccine Venous Thromboembolism viral infection [DOI] 10.3390/medicina57100997 PMC 바로가기 [Article Type] Brief Report
Persistent endotheliopathy in the pathogenesis of long COVID syndrome장기 코로나 증후군의 발병기전에서 지속되는 내피병증Brief Report Published on 2021-09-122022-09-10 Journal: Journal of thrombosis and haemostasis : JTH [Category] MERS, SARS, 바이오마커, [키워드] 95% CI Activation acute phase acute phase response addition Antigen autopsy studies autopsy study Biomarker breathlessness change comorbid patients contribute Control convalescent convalescent COVID‐19 correlated COVID COVID‐19 COVID‐19 patient COVID‐19 patients elevated Endothelial cell endothelial cell (EC) activation endotheliopathy Exercise Tolerance factor VIII fatigue Hospitalization immunothrombosis independent independent of Long COVID mechanism median NETosis objective Older parameter Pathogenesis Patient persistent plasma propeptide prothrombotic raise reported Result SARS‐CoV‐2 infection significantly significantly shorter sustained Symptom syndrome thrombin thrombomodulin Tolerance von Willebrand factor vWF were assessed [DOI] 10.1111/jth.15490 PMC 바로가기 [Article Type] Brief Report
Thrombotic events and COVID-19 vaccinesState of the Art Published on 2021-09-012022-10-29 Journal: The international journal of tuberculosis and lung [Category] COVID-19, SARS, [키워드] administration AEs age approved benefit COVID-19 COVID-19 complication COVID-19 vaccine database death European evaluate event Factor greater Immune thrombocytopenia indicated mRNA vaccine pandemic Post-marketing surveillance proceed prothrombotic Randomised clinical trials recommendations reported review risk Safe SARS-CoV-2 severe adverse event suggested the vaccine thromboembolic thrombosis thrombotic event union vaccination Vaccine Vaccines Viral vector vaccines was performed women [DOI] 10.5588/ijtld.21.0298 PMC 바로가기 [Article Type] State of the Art
Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19병원성 지질 결합 항인지질 항체는 COVID-19의 중증도와 관련이 있습니다Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 진단, 치료기술, 치료제, [키워드] accelerate analyzed antibody antiphospholipid antibodies antiphospholipid antibody association Blood Blood coagulation blood coagulation disorder C-reactive protein catastrophic Cell Clinical course Clinical severity Coagulation coagulation disorder Coagulopathy Cohort complex Concentration coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 patients Critical D-dimer dependent on described detectable dimer disease severity endothelial endothelial cells endothelial protein C receptor EPCR expand hallmark Hospitalized hospitalized COVID-19 patients IgG induce Infection Inflammation inflammatory effects Inflammatory response Lipid manifestation marker median Microvascular thrombosis monocyte Monocytes Mortality outcome pathogenic Patient poor prognosis producing Protein protein C prothrombotic prothrombotic syndrome receptor respiratory secreting Severe acute respiratory syndrome severity of COVID-19 signaling pathway single center stroke syndrome thrombosis thrombotic Thrombus thrombus formation venous [DOI] 10.1111/jth.15455 PMC 바로가기 [Article Type] Article
Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic ThrombocytopeniaInfectious Disease Published on 2021-09-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] adverse effect antibody AstraZeneca AstraZeneca vaccine ChAdOx1 nCoV-19 challenge clinical clinical history coronavirus disease COVID-19 COVID-19 vaccine described Diagnosis disorder ELISA enzyme-linked immunosorbent first dose functional heparin HIPAA immune individual Intracerebral hemorrhage Oxford-AstraZeneca Patient PF4 platelet activation positive prothrombotic receiving SARS-CoV-2 tested thrombocytopenia thrombosis thrombotic Vaccines [DOI] 10.7759/cureus.17637 PMC 바로가기 [Article Type] Infectious Disease
COVID-19 and Acute Coronary Syndromes: From Pathophysiology to Clinical PerspectivesReview Article Published on 2021-08-302022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS, [키워드] addition Affect aggregation Anemia atherosclerotic plaque cardiovascular risk cellular damage clinical Clinical course condition Coronary coronary syndrome coronavirus disease COVID-19 COVID-19 patient decrease described Effect Endothelial cell Endothelial dysfunction expression generate Hyperinflammatory hypoxic induce Injury Local Logistic management Microvascular thrombosis Mortality myocardial damage Myocardial infarction oxidative stress oxygen oxygen supply Pathogenesis pathophysiology Patient Perspective Platelet platelets count potential mechanism promote Prothrombin time prothrombotic prothrombotic state reflect reported Research Sepsis severe disease Shock subject superoxide anions systemic inflammatory response therapeutic thrombus formation tissue type 1 MI von Willebrand factor with COVID-19 [DOI] 10.1155/2021/4936571 PMC 바로가기 [Article Type] Review Article
Complement and the prothrombotic stateReview article Published on 2021-08-202022-10-05 Journal: Blood [Category] 비임상, [키워드] Activation affecting Anticoagulant antiplatelet approval Atypical Autoimmune blood cell catastrophic CD55 CD59 clinical evidence Clinical management complement Complement pathway concerning condition deficiency diagnostic disease etiology Ex vivo feature hemolytic anemia Hemostasis high mortality Host humans Hyperactivation in vitro inhibition inhibitor life-threatening molecular interaction morbidity Occurrence paroxysmal nocturnal hemoglobinuria Patient Prevent protein-losing enteropathy prothrombotic prothrombotic state Regulation Regulatory responsible syndrome the disease therapeutic Therapies therapy thrombosis thrombotic event treated uremic syndrome [DOI] 10.1182/blood.2020007206 [Article Type] Review article