Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem BiopsiesArticle Published on 2022-10-272023-06-23 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신종인플루엔자, [키워드] COVID-19 cytokine immunohistochemistry Inflammasome oxidative stress pulmonary tissue pyroptosis [DOI] 10.3390/ijms232113033 PMC 바로가기
IL-6 drives T cell death to participate in lymphopenia in COVID-19Research article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] activated T cells affecting analyzed caused CD4+ T cell change Course COVID-19 COVID-19 cytokine storm COVID-19 patients Critical death disease Disease progression early stage Hospitalization hospitalized COVID-19 patient ICU care IFN-γ IL-1β IL-6 Immune status induce infected patients Infection laboratory result lymphopenia maintain observation Patient patients patients with COVID-19 plasma concentration predict pyroptosis Randomly reduction reduction in Result SARS-CoV-2 selected severity supported T cell T cell lymphopenia T lymphocyte T-cell the disease TNF-α [DOI] 10.1016/j.intimp.2022.109132 [Article Type] Research article
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohortArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C Multisystem inflammatory syndrome Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined [DOI] 10.3389/fimmu.2022.992022 PMC 바로가기
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Research Published on 2022-08-042022-10-05 Journal: The Pan African Medical Journal [Category] 변종, [키워드] Analysis contributed defined demonstrated DNA dysregulated exacerbate gasdermin D Genetic GSDMD implicated incidence Inflammation inflammatory cell Inflammatory cytokine Inflammatory cytokines mice mitochondrial NET Neutrophil extracellular trap oxidized Paquinimod pathology Patient pharmacological Platelet positive feedback loop promoted proteomic pyroptosis rapid clinical deterioration Sepsis Signaling significantly increased survival TLR4 toll-like receptor 4 triggering upregulation [DOI] 10.1038/s44161-022-00108-7 [Article Type] Research
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Serum gasdermin D levels are associated with the chest computed tomography findings and severity of COVID-19Research article Published on 2022-07-012022-10-05 Journal: Respiratory investigation [Category] 바이오마커, 치료기술, [키워드] Affect Apoptosis apoptotic Area association Caspase-cleaved cytokeratin 18 fragment Chest computed tomography Chest CT clinical manifestation clinical status conducted consolidation COVID-19 Critical cross-sectional analysis diagnosed with COVID-19 died Excessive activation gasdermin D Ground glass opacity GSDMD immune response marker mechanical ventilation Mild moderate Patient patients with COVID-19 positively correlated programmed cell death pyroptosis required Result serum severe group severity of COVID-19 the disease three group [DOI] 10.1016/j.resinv.2022.06.007 [Article Type] Research article
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19세포 사멸: COVID-19의 병인 및 중재 요법에 대한 참여Review Published on 2022-06-132022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis autophagy caused Cell cell death coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease disease pathogenesis Effective strategies effective strategy Ferroptosis homeostasis Host Increasing indicated Infection Interaction Intervention involved Involvement knowledge lack mechanism necroptosis NETosis Occurrence pandemic Pathogenesis pathogenicity pathology present Prevent progression pyroptosis SARS-CoV-2 severe acute respiratory syndrome Coronavirus Therapies therapy treat virus infection [DOI] 10.1038/s41392-022-01043-6 PMC 바로가기 [Article Type] Review