Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmissionResearch Article Published on 2021-11-232022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] animal Combination comparable Contact correlated COVID-19 cycle Endemic heterogeneous high risk immune protection Immunity in both group Infection initial intranasally modeling natural infection Observed occur ranged RAT Result risk SARS-CoV-2 SARS-CoV-2 propagation seroconversion rate seropositive stability susceptible susceptible individuals threshold value Transmission vaccinated individual vaccinated individuals vaccination viral shedding virus [DOI] 10.1371/journal.pone.0260038 PMC 바로가기 [Article Type] Research Article
Safety and Immunogenicity Analysis of a Newcastle Disease Virus (NDV-HXP-S) Expressing the Spike Protein of SARS-CoV-2 in Sprague Dawley RatsSprague Dawley 쥐에서 SARS-CoV-2의 스파이크 단백질을 발현하는 뉴캐슬병 바이러스(NDV-HXP-S)의 안전성 및 면역원성 분석Immunology Published on 2021-11-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (Alpha) (Beta acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Alpha animal model Antibody titer Antibody titers approach B.1.1.7 B.1.351 B.1.617.2 Beta boost Brazil clinical clinical testing coronavirus country COVID-19 elicited expand expressing followed by Histopathology Immunity immunogenicity immunogenicity analysis induce intramuscularly intranasally Local mucosal Neutralizing activity newcastle disease virus performed Post-mortem pre-fusion RAT rat model reactogenicity regimen Region respiratory robust Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine second serum antibodies serum antibody severe acute respiratory syndrome Coronavirus Spike protein Spread systemic reactions tested the Spike the spike protein the United State the vaccine Toxicity United States vaccination vaccination rate Vaccine vaccine administration variants of concern VOCs were assessed wild type [DOI] 10.3389/fimmu.2021.791764 PMC 바로가기 [Article Type] Immunology
Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2SARS-COV-2의 델타 변이체 (B.1.617.2)에 대한 빠른 항원 시험의 비교 민감도Comparative Study Published on 2021-10-292022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 2019-nCoV Antigen B.1.617.2 cartridge Comparative COVID-19 COVID19 Delta delta variant Diagnosis examined Fuji individual Infectious virus Influenza Japan lateral flow immunoassay Lateral flow immunoassays less mind nCoV pfu Rapid rapid antigen test Rapid antigen tests Rapid test RAT RATs SARS-CoV-2 SARS-CoV-2 antigen sensitivities sensitivity specimen Test tested the SARS-CoV-2 variant variety virus [DOI] 10.3390/v13112183 PMC 바로가기 [Article Type] Comparative Study
Emerging SARS-CoV-2 variants expand species tropism to murinesResearch Paper Published on 2021-10-212023-06-17 Journal: EBioMedicine [Category] MERS, SARS, [키워드] mouse murine N501Y RAT SARS-CoV-2 variants susceptibility [DOI] 10.1016/j.ebiom.2021.103643 PMC 바로가기 [Article Type] Research Paper
SDAV, the Rat Coronavirus—How Much Do We Know about It in the Light of Potential ZoonosesReview Published on 2021-10-042022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, MERS, 조류인플루엔자, [키워드] Bacteria caused Characteristics coronavirus Coronaviruses cross demonstrated Epidemic etiological agent fungi highlight Host Human Infection infections knowledge Laboratory LIGHT pandemic Potential Protozoa provide RAT rat infections reservoir salivary SDAV the Coronaviridae Topic virus viruses zoonoses zoonotic zoonotic disease [DOI] 10.3390/v13101995 PMC 바로가기 [Article Type] Review
Eicosanoid Metabolomic Profile of Remdesivir Treatment in Rat Plasma by High-Performance Liquid Chromatography Mass SpectrometryPharmacology Published on 2021-09-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Administered administration Analysis AUC baseline blood sample C max caused Chromatography collected Concentration correlated COVID-19 COVID-19 patients discrepancy dose eicosanoid Eicosanoids GS-441524 HPLC-MS/MS Immunity Inflammation Inflammatory initial intravenously investigated involved liquid mass metabolite metabolomics nucleotide parameter Pearson correlation PGE2 pharmacokinetic pharmacological profile RAT reduced Remdesivir reported robust SARS-CoV-2 SARS-CoV-2 virus infection significantly Spectrometry therapy Treatment Variation was performed [DOI] 10.3389/fphar.2021.747450 PMC 바로가기 [Article Type] Pharmacology
Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues비만 및 케톤 생성 식단은 쥐의 폐와 심장 조직에서 SARS-CoV-2 진입 단백질 ACE2 및 TMPRSS2와 레닌-안지오텐신 시스템을 뚜렷하게 조절합니다Article Published on 2021-09-252022-09-10 Journal: Nutrients [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Affect Alter angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-inflammatory effect attenuate components diet elevated enzyme Gene Expression heart hearts IL6 increase individuals Inflammation inflammatory gene inflammatory genes interleukin-6 interleukin-6 receptor ketogenic Ketogenic diet Ketogenic Diets ketones lung lung tissues Lungs MasR mechanism Migration obese obesity obesogenic outcomes protease Protein RAS RAT Renin renin-angiotensin system SARS-CoV-2 SARS-CoV-2 entry Serine serine 2 severity Severity of infection sucrose System tested the SARS-CoV-2 tissues TLR4 TMPRSS2 TMPRSS2 level TMPRSS2 levels TNF-alpha Toll-like receptor toll-like receptor 4 transmembrane transmembrane protease serine 2 Viral viral entry were measured [DOI] 10.3390/nu13103357 PMC 바로가기 [Article Type] Article
Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in RatsArticle Published on 2021-09-192022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration Analysis blood plasma Bronchoalveolar lavage fluid caused co-spray coronavirus Coronavirus disease 2019 COVID-19 distribution Dry powder inhaler Ex vivo in vitro in vivo inhibitor intratracheal administration intravenous lecithin lung lung tissue mannitol mesylate Microparticle nafamostat Nafamostat mesylate new strain pharmacokinetics pulmonary RAT respiratory tract SARS-CoV-2 SARS-CoV-2 S spray stability suppresse tissue transmembrane serine protease [DOI] 10.3390/pharmaceutics13091519 PMC 바로가기 [Article Type] Article
In Vitro Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta)Communication Published on 2021-09-162022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 229E Antigen B.1.1 B.1.1.7 B.1.1.7 (Alpha) B.1.351 B.1.351 (Beta) B.1.617.2 B.1.617.2 (Delta) Beta cell culture medium circulating comparable concern conducted containment strategies cross-reactivity Delta detect dilution sery evaluated Gamma HCoV HCoVs HKU1 human corona viruses (hCoVs) human coronavirus investigated Laboratory limit of detection mutations N-protein nasal swab NL63 OC43 P.1 P.1 (Gamma) pathogen performance Rapid rapid antigen test performance RAT RATs required Saliva SARS-CoV-2 SARS-CoV-2 rapid antigen tests strain Strains Test the SARS-CoV-2 variants variants of concern variants of concern (VOCs) VoC VOCs was determined [DOI] 10.3390/microorganisms9091967 PMC 바로가기 [Article Type] Communication
Sensitivity of Rapid Antigen Testing and RT-PCR Performed on Nasopharyngeal Swabs versus Saliva Samples in COVID-19 Hospitalized Patients: Results of a Prospective Comparative Trial (RESTART)Article Published on 2021-09-092022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen applied approach assays Basel biosensor collected Comparative conducted COVID-19 COVID-19 diagnosis Diagnosis diagnostic duration of symptom exhibited help Hospitalized hospitalized patient hospitalized patients intensive care investigated IQR mitigate much lower nasopharyngeal Nasopharyngeal swab Non-invasive Patient Prospective prospective observational study Rapid rapid antigen test rapid antigen testing RAT RATs Result RT-PCR RT-PCR testing Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 diagnosis sensitivity shortage of reagent specificity specimen Standard Q step Swab swabs Switzerland Test Testing the median Viral transport medium VTM was used [DOI] 10.3390/microorganisms9091910 PMC 바로가기 [Article Type] Article