Harvest for Health, a Randomized Controlled Trial Testing a Home-Based, Vegetable Gardening Intervention Among Older Cancer Survivors Across Alabama: An Analysis of Accrual and Modifications Made in Intervention Delivery and Assessment During COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of the Academy of Nutrition and Dietetics [Category] 임상, [키워드] Analysis anticipated approach assessment assigned Baseline assessment Breast cancer Cancer Controlled COVID-19 COVID-19 pandemic cross-over delivery diet dissemination Effect eligible enrolled Enrollment Evidence female functional gardening Harvest Health IMPROVE indicated Intervention Modification not differ objective Older Older adults outcome outcome measure participant performed physical physical activity Physical function populations primary end point protocol Quality of life Randomized Randomized controlled trial Randomly RCT recruited recruitment reported Result screened significantly higher survival survivor Survivors survivorship T Test Testing Trial vegetable were used widespread [DOI] 10.1016/j.jand.2022.05.005 [Article Type] Research article
Effect of intensive weight-loss intervention on metabolic, ultrasound and anthropometric parameters among patients with obesity and non-alcoholic fatty liver disease: an RCTRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European journal of clinical nutrition [Category] 임상, [키워드] ALT AST attenuation baseline BMI Completer Contact Control control arm Controlled Effect effective Efficacy exacerbated Fatty liver groups hospital India Intensive Intervention intervention arm liver enzymes measurement NAFLD normalized obesity outcomes pandemic parameter parameters participant Patient patients with obesity Randomized RCT significant decrease significantly significantly higher steatosis stiffness therapy treat analysis Treatment outcome Trial was done weight were measured [DOI] 10.1038/s41430-022-01111-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent PlasmaArticle Published on 2022-09-012022-11-15 Journal: Annals of internal medicine [Category] SARS, 진단, 치료기술, [키워드] AABB addition Admission advancement antibody assessment Biotherapy CCP clinical Clinical practice close contact convalescent plasma Coronavirus disease 2019 COVID-19 development Disease progression effective Evidence Good Clinical Practice GRADE framework guideline high risk Hospitalized hospitalized patient immunosuppressed patient Immunosuppression infected patient lack Meta-analysis moderate Neutralizing titer Outpatient Participants Potential treatment Practice Prophylactic Randomized controlled trial RCT RCTs recommendation recommendations SARS-CoV-2 SARS-CoV-2 antibody severe disease Standard of care symptom onset systematic review transfused uninfected with COVID-19 [DOI] 10.7326/M22-1079 PMC 바로가기
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral SclerosisRandomized Controlled Trial Published on 2022-08-292022-10-05 Journal: Neurology® neuroimmunology & neuroinflammation [Category] 바이오마커, 임상, [키워드] 1:1 ALS assigned autologous average baseline changed class classification clinical study Combined conducted COVID-19 pandemic Disease progression Dose escalation dose-escalation doses effective elevated enrolled Evidence extension Good group help IL-2 Inflammation injection intervals Lateral Sclerosis LDL Leukapheresis low-density marker matching placebo Open-label oxidative stress oxidized participant Patient Person Placebo Practice progression provide Randomized controlled trial Randomly RCT receive receptor Regulatory reliability Safe slow disease suppressive function T-lymphocyte therapy Treatment Treg Tregs Year [DOI] 10.1212/NXI.0000000000200019 PMC 바로가기 [Article Type] Randomized Controlled Trial
Notes from an epicenter: navigating behavioral clinical trials on autism spectrum disorder amid the COVID-19 pandemic in the BronxRandomized Controlled Trial Published on 2022-08-192022-10-05 Journal: Trials [Category] 임상, [키워드] adjust Applied behavior analysis autism spectrum Autism Spectrum Disorder autistic Behavioral intervention children clinical trial COVID-19 COVID-19 pandemic disorder event functional impacted increasingly integration offer pandemic participant presenting primary outcome measure protocol Randomized controlled trial RCT recruitment Research resource risk Sensory Sensory integration therapy. Study protocol sustained therapy unique utility [DOI] 10.1186/s13063-022-06635-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Clinical Efficacy and Safety of Anti-Viral Agents for Non-Hospitalized Patients with COVID-19: A Systematic Review and Network Meta-Analysis of Randomized Controlled TrialsCOVID-19를 가진 비 병원 환자에 대한 항 바이러스 제제의 임상 효능 및 안전성 : 무작위 대조 시험의 체계적인 검토 및 네트워크 메타 분석Review Published on 2022-08-022022-08-31 Journal: Viruses [Category] meta-analysis, 임상, 치료제, [키워드] adverse event adverse events agent anti-viral agent anti-viral agents Anti-viral treatment best calculated clinical Clinical efficacy clinical setting Cochrane Library Controlled controlled trials COVID-19 death determined by Disease progression followed by Hospitalization increased risk Intravenous remdesivir investigated lowest molnupiravir network Network meta-analysis Nirmatrelvir nirmatrelvir plus ritonavir Patient patients with COVID-19 Placebo Probability Randomized controlled trial RCT RCTs receiving registry Remdesivir review risk risk of COVID-19 Ritonavir Safety searched shown significantly lower the WHO tolerable Treatment Web of Science WHO International Clinical Trials Registry Platform [DOI] 10.3390/v14081706 PMC 바로가기 [Article Type] Review
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials심혈관계 약물 및 코로나19 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-08-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval Accuracy ACEi ACEIs amlodipine angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Anticoagulants anticoagulation antiplatelet approved ARBs Aspirin atorvastatin baseline blocker calcium calcium channel calcium channel blockers cardiovascular cardiovascular drugs Clinical outcome Completeness COVID-19 COVID-19 severity database drug Evidence had no Hospitalization identify initiated investigated Living systematic review mean difference meta-analyses Meta-analysis moderate Mortality no effect not affect observational studies observational study Other outcomes Prevent Quantitative Randomized controlled trial RCT RCTs receptor receptor blocker reported risk risk ratio searched severity sulodexide systematic review therapeutic therapeutic anticoagulation treat Trial trials [DOI] 10.1111/bcp.15331 PMC 바로가기 [Article Type] Review
The clinical efficacy and safety of mesenchymal stromal cells for patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials코로나19 환자를 위한 중간엽 기질세포의 임상적 효능 및 안전성: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] 신약개발, 임상, [키워드] 28-day mortality 95% CI addition adverse event adverse events AEs appear Clinical efficacy Clinical improvement Clinical outcome clinical outcomes ClinicalTrials Cochrane Library control group controls COVID-19 help IMPROVE investigated Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Mortality mortality rate MSC MSCs OVID Patient patients patients with COVID-19 Placebo placebos Randomized controlled trial Randomized controlled trials RCT RCTs risk Safe SARS-CoV-2 searched serious AE serious AEs significantly higher significantly lower stromal cell stromal cells systematic review therapeutic option treat Treatment [DOI] 10.1016/j.jiph.2022.07.001 PMC 바로가기 [Article Type] Meta-Analysis
Emerging Therapies for COVID-19: The Value of Information From More Clinical TrialsCOVID-19에 대한 새로운 치료법: 더 많은 임상 시험에서 얻은 정보의 가치Article Published on 2022-08-012022-09-11 Journal: Value in health : the journal of the International [Category] 임상, 진단, [키워드] Analysis approval approved Baricitinib benefit Casirivimab clinical clinician Cohort consequence Cost-benefit analysis COVID-19 COVID-19 pandemic decision support techniques Dexamethasone drug approval. effective Emergency use authorization Evidence Health healthcare hospitalized patient hospitalized patients Hydroxychloroquine Imdevimab implementation information interferon interferon beta Interferon beta-1a Lopinavir Lopinavir-ritonavir outcome pandemic Perspective Randomized controlled trial RCT RCTs Remdesivir Research Ritonavir seeking Support therapy threshold Tocilizumab usual care value with COVID-19 [DOI] 10.1016/j.jval.2022.03.016 PMC 바로가기 [Article Type] Article
High-cited favorable studies for COVID-19 treatments ineffective in large trialsResearch article Published on 2022-08-012022-10-05 Journal: Journal of clinical epidemiology [Category] 신약개발, 유전자 메커니즘, 임상, 치료법, [키워드] Altmetric article benefit bias citation citations clinical study clinical trial Colchicine convalescent plasma coronavirus disease correlated correlated strongly COVID-19 COVID-19 treatment Critical Effectiveness eligible evaluate examined Features Hydroxychloroquine interferon Intervention large trial Lopinavir-ritonavir nine Nonrandomized studies objective observational study patients Randomized controlled trial Randomized controlled trials randomized trial RCT RCTs Remdesivir Result setting Study design subsequent Treatment [DOI] 10.1016/j.jclinepi.2022.04.001 [Article Type] Research article