PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patientsPF-07321332(니르마트렐비르)는 인간 ENT1 또는 ENT2와 상호작용하지 않음: COVID-19 환자에 대한 시사점Article Published on 2022-07-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury antivirals bind Biotransformation Clinical efficacy clinical trials contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death downregulation drug Efficacy EIDD-1931 Emergency use authorization Endothelial cell ENT ENTs expression Factor FDA food greater hypoxia in vitro inhibitor Interaction investigated lung epithelial Lung injury Lungs metabolite molnupiravir Nirmatrelvir nucleoside nucleoside analog nucleoside analogs pandemic Patient patients with COVID-19 PF-07321332 protease Protease inhibitor reflected Remdesivir Replication repression SARS-CoV-2 Severe acute respiratory syndrome shown substrate substrates the SARS-CoV-2 undergo unlikely US Food and Drug Administration viral replication Viral RNA Virology [DOI] 10.1111/cts.13292 PMC 바로가기 [Article Type] Article
Wastewater based epidemiology as a silent sentinel of the trend of SARS-CoV-2 circulation in the community in central Argentina아르헨티나 중부 지역 사회에서 SARS-CoV-2 순환 추세의 조용한 감시자로서의 폐수 기반 역학Article Published on 2022-07-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha analyzed circulating circulation collected Community Córdoba COVID-19 COVID-19 cases COVID-19 pandemic Delta VOC delta VoCs described detection detection rate E gene effective Epidemiology FIVE Gamma Genes Genome geographical area geographical areas infected individuals information methodology monitoring N gene pandemic pathogen plant polyethylene Polyethylene glycol positive precipitation method public health measures real time reflected RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants SARS-COV-2 variants in wastewater silent stable population Support Surveillance symptomatic and asymptomatic the SARS-CoV-2 genome Valley variant viral genome viral genomes viral variant Viral variants virus VoC VOCs warning sign wastewater Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118541 PMC 바로가기 [Article Type] Article
Third trimester messenger RNA COVID-19 booster vaccination upsurge maternal and neonatal SARS-CoV-2 immunoglobulin G antibody levels at birth임신 3기 전령 RNA COVID-19 부스터 백신 접종 시 산모 및 신생아 SARS-CoV-2 면역글로불린 G 항체 수준 급증Article Published on 2022-07-012022-09-12 Journal: European journal of obstetrics, gynecology, and re [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval Administered administration Admission analyzed antibodies antibody Antibody titers Blood BNT162b2 BNT162b2 mRNA body mass index booster booster dose booster vaccination Booster vaccine Characteristics contrary correlation COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine dropped evaluate IgG Immunoglobulin increase in Messenger RNA mRNA multivariable analysis Neonatal Newborn pandemic Pfizer/BioNTech Placenta positive correlation Pregnancy pregnant women prospective cohort study reflected response SARS-CoV-2 SARS-CoV-2 IgG antibody Side effect Standard deviation Support systemic side effect Third trimester. umbilical vaccination Vaccine vaccine dose were measured women [DOI] 10.1016/j.ejogrb.2022.05.029 PMC 바로가기 [Article Type] Article
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone [DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article
Drivers of adaptive evolution during chronic SARS-CoV-2 infections만성 SARS-CoV-2 감염 중 적응 진화의 동인Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive antibody chronic infection chronic infections coronavirus correlated driver Drivers Evidence Evolution feature Hypothesis immune system Immunocompromised patient in some Infection MOST Most patients Mutation Patient patients Population reflected SARS-CoV-2 SARS-COV-2 infection searched Sequencing subset Substitution tested Transmissibility Transmission variants variants of concern VoC VOCs [DOI] 10.1038/s41591-022-01882-4 PMC 바로가기 [Article Type] Article
Identification of phytocompounds as newer antiviral drugs against COVID-19 through molecular docking and simulation based study분자 도킹 및 시뮬레이션 기반 연구를 통한 COVID-19에 대한 새로운 항바이러스 약물로서의 식물 화합물 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] 변종, 치료제, [키워드] ADMET analysis Analysis antiviral activity antiviral drug antiviral drugs binding affinity complex conformational contagious COVID-19 docking docking score flexibility free energy free energy landscape identification in silico molecular docking molecular dynamic simulation molecular interaction pandemic Phytocompounds. promoted protease reflected screened selected Spike protein stability target protein target proteins variant Variation Viral protein Viral proteins Virtual screening virus was performed was used [DOI] 10.1016/j.jmgm.2022.108192 PMC 바로가기 [Article Type] Article
Monitoring of SARS-CoV-2 in sewersheds with low COVID-19 cases using a passive sampling technique수동 샘플링 기술을 사용하여 COVID-19 사례가 낮은 하수도에서 SARS-CoV-2 모니터링Article Published on 2022-06-302022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 치료기술, [키워드] applied approach city Cluster Community COVID-19 COVID-19 case COVID-19 infection COVID-19 transmission detect detects dilutions effective Epidemiology feasible individual infected individuals information membrane monitoring number of infected Passive Passive samplers provide reflected RNA SARS-CoV-2 SARS-CoV-2 RNA sensitivity spatiotemporal Spread Surveillance Treatment upstream Upstream sampling wastewater wastewater surveillance Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118481 PMC 바로가기 [Article Type] Article
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study면역학적 매개변수를 추가하여 COVID-19에서 임상 실험실 테스트의 한계를 노출하고 극복합니다. 후향적 코호트 분석 및 파일럿 연구Article Published on 2022-06-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute phase acute phase reactants Adding adopted age Alanine alanine aminotransferase Algorithm Analysis aspartate Aspartate aminotransferase association Barcelona best Biomarker C-reactive protein category CCL2 chemokines classical clinical clinical and laboratory variables clinical laboratories clinical laboratory clinical laboratory tests Clinical management clinical parameter Clinical parameters clinical variable clinical variables Cohort collected Comorbidity conducted COVID 19 patient COVID 19 patients COVID-19 COVID-19 pandemic COVID-19 patient CXCL10 cytokine Cytokines exploratory feasible fibrinogen filtration rate First wave flow cytometry fraction glomerular filtration rate IL-1ra IL-6 immune response immunological Immunological test immunological tests IMPROVE independent Inflammation Interpretation Laboratory Laboratory test Laboratory tests limitation lymphocyte neutrophil organ organ damage outcome overcome oxygen oxygen saturation pandemic patients performed phenotype pilot study Predictive predictive power predictive risk-profile. predictor Prognosis redundancy reflected SARS-CoV-2 SARS-COV-2 infection severity statistical statistical analysis survival Test two subgroup two subgroups understanding validation cohort validation cohorts variable [DOI] 10.3389/fimmu.2022.902837 PMC 바로가기 [Article Type] Article
Infodemiological study on the impact of the COVID-19 pandemic on increased headache incidences at the world level Research Published on 2022-06-172022-10-05 Journal: Scientific Reports [Category] 치료기술, 치료법, [키워드] absence accelerated Accuracy aggregate Algorithms Analysis automated baseline Canada caused Coronavirus infections correlation country COVID-19 infection COVID-19 pandemic Factor finding Frequency Google headache Health incidence increasingly India information Internet Kenya machine-learning management measure mental health problems Occurrence Other outbreak Pain pandemic platform producing reflected research finding Result searched South Africa statistical Stress trend Volume Weekly [DOI] 10.1038/s41598-022-13663-7 [Article Type] Research
Decay of anti-Bordetella pertussis antibodies in women of childbearing age following COVID-19 non-pharmaceutical measuresCOVID-19 비약물적 조치에 따른 가임기 여성의 항보르데텔라 백일해 항체 붕괴Article Published on 2022-06-152022-09-12 Journal: Vaccine [Category] MERS, 백일해, 진단, [키워드] 95% CI Annual Antenatal immunization antibody assigned blood sample Bonferroni correction Bordetella pertussis Canada changed childbearing age collected Coronavirus disease 2019 COVID-19 COVID-19 pandemic decay declined female gestation healthy IgG IgG level IgG levels Immunity Immunoglobulin G implementation incidence Infant Infection Level lowest measure morbidity P-value pertussis Pregnancy pregnant women reduce reflected reported respiratory pathogen sera significantly statistical significance t tests tested transfer women [DOI] 10.1016/j.vaccine.2022.04.086 PMC 바로가기 [Article Type] Article