Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Cardiac Troponin Testing as a Component of Return to Play Cardiac Screening in Young Competitive Athletes Following SARS-CoV-2 InfectionArticle Published on 2022-08-162022-11-16 Journal: Journal of the American Heart Association [Category] SARS, 치료기술, [키워드] age appear athlete Athletes Black race cardiac Cardiac imaging cardiac troponin Cohort component condition criteria cTn database detectable Diagnosis diagnostic female inclusion criteria interquartile range limit limits magnetic resonance imaging median time myocardial involvement Observational cohort study protocol registry Result return return‐to‐play SARS-CoV-2 SARS-COV-2 infection SARS‐CoV‐2 Screening stratified Testing to define troponin undetectable utility [DOI] 10.1161/JAHA.122.025369 PMC 바로가기
Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trialRandomized Controlled Trial Published on 2022-08-162022-10-05 Journal: eLife [Category] 임상, [키워드] Adding Affect behavior change change clinical conducted COVID-19 COVID-19 vaccine driver Effect Epidemiology Evidence fear global health Human independent individual Mortality nudges participant population level presenting Randomized controlled trial receive reduce registry risk Risk communication Safe severity Side-effect the United State the vaccine Trial United Kingdom Vaccine Vaccine hesitancy vaccine intention [DOI] 10.7554/eLife.78765 PMC 바로가기 [Article Type] Randomized Controlled Trial
Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label, multicentre, and randomised phase-1/2 and phase-2 clinical trialsClinical Trial Published on 2022-08-122022-10-05 Journal: EBioMedicine [Category] SARS, 변종, 임상, 진단, [키워드] adverse event Anti-RBD IgG AstraZeneca baseline Biotechnology Cellular immune response cellular immune responses clinical clinical trial Coalition conducted convalescent serum correlation COVID-19 COVID-19 vaccination COVID-19 vaccine CpG1018 Department domain doses Efficacy finding foundation funding groups humoral immune responses incidence India Innovation Melinda Gate Moderna multicentre NAb neutralising antibody observation Open-label profile Protein subunit randomised randomly divided Receptor-binding domain Registered registry reported safety profile SARS-CoV-2 SARS-COV-2 infection second dose significantly Spike protein the vaccine titre titres Trial Vaccine [DOI] 10.1016/j.ebiom.2022.104217 [Article Type] Clinical Trial
Atorvastatin for reduction of 28-day mortality in hospitalized COVID-19 patients: study protocol for a randomized, double-blinded, placebo-controlled, clinical trial입원한 COVID-19 환자의 28일 사망률 감소를 위한 아토르바스타틴: 무작위, 이중 맹검, 위약 대조, 임상 시험을 위한 연구 프로토콜Article Published on 2022-08-082022-09-11 Journal: Trials [Category] SARS, 임상, [키워드] 28-day mortality 95% confidence interval Acute kidney injury added adjusted odds ratio All participants all-cause mortality anti-inflammatory drug approval assigned atorvastatin being clinical Clinical improvement clinical trial clinician Consequences Consistency coronavirus COVID-19 COVID-19 patient Delta disease double-blinded drug events healthcare worker Hmg coa hospital hospitalized COVID-19 hospitalized patients In-hospital in-hospital mortality Informed consent institutional review board intensive care isolation hospital logistic regression model mass vaccination mechanical ventilation Mortality neurological once daily P-value pandemic pandemic era participant Patient performed Placebo placebo-controlled Primary outcome protocol Psychological Randomized randomized clinical trial Randomized controlled trial receive recruited reduce mortality reduced reduction Registered registry Research SARS-CoV-2 Sepsis severity severity of COVID-19 standard treatment statins Study protocol supported Tablet the patient university vaccination [DOI] 10.1186/s13063-022-06619-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Transmission by Arthropod Vectors: A Scoping Review절지동물 벡터에 의한 SARS-CoV-2 전파: 범위 검토Review Published on 2022-08-082022-09-11 Journal: BioMed Research International [Category] SARS, 치료기술, [키워드] aerosolization Arthropod arthropods article causative agent cockroaches Community conducted Contamination coronavirus Coronavirus infection COVID-19 COVID-19 virus droplets Families Health health problem healthy healthy carrier hygiene Hygiene care Infection insect Insects interior management naked eye Numerous outbreak Prevention and control problem public health question receiving registry Research reservoir reservoirs Respiratory disease Respiratory droplets review root SARS-CoV-2 SARS-CoV-2 virus shown stools systematic review Transmission Transmission routes Transport unique Vaccines vector vectors virus [DOI] 10.1155/2022/4329423 PMC 바로가기 [Article Type] Review
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)COVID-19의 긴 COVID/급성 후유증(PASC)을 가진 개인의 증상, 동반질환, 섬유소 아밀로이드 미세응고 및 혈소판 병리의 유병률Article Published on 2022-08-062022-09-11 Journal: Cardiovascular Diabetology [Category] SARS, 진단, 치료기술, [키워드] accompanied acute COVID-19 African amyloid Amyloid fibrin(ogen) analysed Atypical balance blood sample Blood samples Brain capillary cardiovascular disease cholesterol Clinical studies clinical study Clinical treatment co-morbidities Comorbidities Comorbidity comparable Concentration controlled clinical studies coronavirus coronavirus 2019 disease COVID-19 COVID-19 severity determine diabetes Diabetes Mellitus Diagnostic method Diversity dyslipidaemia Early detection effective Efficacy endotheliopathy fatigue female FIBRIN Fluorescence fluorescence microscopy foci Gender Hyperactivated platelets hypertension individual inhibit joint Long Long COVID/PASC morbidities muscle pains ogen PASC pathology Patient patients Platelet platelet hyperactivation Platelets platform provide reducing registry removal reported reversal SARS-COV-2 infection scoring system Shortness of breath South Symptom Symptoms tissues Transport Treatment type 2 diabete Type 2 diabetes mellitus [DOI] 10.1186/s12933-022-01579-5 PMC 바로가기 [Article Type] Article
The Clinical Efficacy and Safety of Anti-Viral Agents for Non-Hospitalized Patients with COVID-19: A Systematic Review and Network Meta-Analysis of Randomized Controlled TrialsCOVID-19를 가진 비 병원 환자에 대한 항 바이러스 제제의 임상 효능 및 안전성 : 무작위 대조 시험의 체계적인 검토 및 네트워크 메타 분석Review Published on 2022-08-022022-08-31 Journal: Viruses [Category] meta-analysis, 임상, 치료제, [키워드] adverse event adverse events agent anti-viral agent anti-viral agents Anti-viral treatment best calculated clinical Clinical efficacy clinical setting Cochrane Library Controlled controlled trials COVID-19 death determined by Disease progression followed by Hospitalization increased risk Intravenous remdesivir investigated lowest molnupiravir network Network meta-analysis Nirmatrelvir nirmatrelvir plus ritonavir Patient patients with COVID-19 Placebo Probability Randomized controlled trial RCT RCTs receiving registry Remdesivir review risk risk of COVID-19 Ritonavir Safety searched shown significantly lower the WHO tolerable Treatment Web of Science WHO International Clinical Trials Registry Platform [DOI] 10.3390/v14081706 PMC 바로가기 [Article Type] Review
Therapeutic ultrasound versus injection of local anesthetic in the treatment of women with chronic pelvic pain secondary to abdominal myofascial syndrome: a randomized clinical trialRandomized Controlled Trial Published on 2022-08-022022-10-05 Journal: BMC Women's Health [Category] 임상, [키워드] abdomen abdominal pain absence analyzed cause characterized chronic clinical clinical trial Comorbidity conducted continuous pain Controlled clinical trial COVID-19 CPP defined dysfunction effective Efficacy evaluate evaluated Evidence exclusion groups IMPROVE injection Local Local anesthesia material Musculoskeletal Myofascial Myofascial pain syndrome no significant difference Pain Patient Pelvic Pelvic pain placebo group Quality of life questionnaire randomized clinical trial reducing Registered registry scale Study participants syndrome Tertiary therapeutic Therapeutic ultrasound Treatment Ultrasonic therapy Ultrasonic therapy. university variable Visual women [DOI] 10.1186/s12905-022-01910-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Cardiopulmonary Imaging Utilization and Findings among Hospitalized COVID-19 Patients in Latin America: (From “RIMAC: Registry IMAging Cardiopulmonary among Hospitalized COVID-19 Patients in LATAM”)Observational Study Published on 2022-08-012022-10-04 Journal: Global Heart [Category] SARS, 임상, [키워드] Admission America association Cardiopulmonary Cardiopulmonary Images carried Chest CT Comorbidities Comorbidity complications conducted COVID-19 COVID-19 hospitalization diabetes Diagnosis discharge Evolution finding ground glass heart highest Hospitalization hospitalized patient hypertension ICU imaging In-hospital death in-hospital mortality information Inpatients interstitial lack LATAM Latin Latin America lung magnetic resonance imaging males median age Myocardial infarction nine pandemic performed predominant prevalent Prognosis Region regions registry RIMAC SARS-CoV-2 severity South America syndrome the SARS-CoV-2 Thromboembolism utilization X-ray [DOI] 10.5334/gh.1134 PMC 바로가기 [Article Type] Observational Study