Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1단백질 키나제 Cak1의 발현 감소를 통한 칸디다 알비칸스 필라멘트/생물막 조절기 우회Research Article Published on 2016-12-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation antimicrobial Antimicrobials bacterial pathogen biofilm bypass Candida Candida albican Candida albicans Cell cell cycle cell growth cell proliferation contribute coupling dependence determinant diminished Effectiveness Express expresse expression Filamentous functional Gene Expression Genes growth implicated induce Infection infections information inhibition invasive kinase leads Medical devices Mutation occur organism pathogen Pathogens proliferation property Protein protein kinase reduced regulator Regulatory required Screen Stimulation strain Strains Target genes the cell transcription factor transcription factors wild-type [DOI] 10.1371/journal.pgen.1006487 PMC 바로가기 [Article Type] Research Article
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory VirusesResearch Article Published on 2013-07-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] approach both virus component conserved Critical dataset disease pathology effort epithelial cell event Factor feature Gene Host host response human lung identify Infection influence Influenza virus influenza virus integration Interaction Intervention involved lung epithelial Metrics network Pandemics pathogen pathogenicity predict predicted proteome public health threat Regression model regulator Regulatory related respiratory respiratory virus SARS-CoV severe therapeutic target transcriptome dataset utility viral pathogenesis virus virus [DOI] 10.1371/journal.pone.0069374 PMC 바로가기 [Article Type] Research Article
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article