Accelerating development of new shorter TB treatment regimens in anticipation of a resurgence of multi-drug resistant TB due to the COVID-19 pandemicResearch article Published on 2021-12-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 신약개발, 치료법, [키워드] Affect anticipated clinical trials Combination COVID-19 COVID-19 pandemic diagnosed diagnostic diagnostics drug Drug discovery drug regimens drug resistance drugs estimate Follow-up Health Service highlight Impact implementation Investing lower mortality MDR-TB multi-drug resistant National New drugs New treatment regimens Patient Pipeline positive regimen report Repurposed drug required tolerable Treatment Treatment outcome treatment regimen Tuberculosis WHO WHO guideline [DOI] 10.1016/j.ijid.2021.02.067 [Article Type] Research article
Host-modifying drugs against COVID-19: some successes, but not yet the breakthroughCOVID-19에 대한 숙주 변형 약물: 일부 성공, 그러나 아직 돌파구 없음Review Published on 2021-12-012022-09-11 Journal: Environmental microbiology [Category] meta-analysis, SARS, 임상, 치료제, [키워드] Anakinra anti-inflammatory treatment antibiotic anticoagulation antiviral drug antiviral drugs Azithromycin Baricitinib benefit clinical clinical benefit clinical benefits clinical trial clinical trials Colchicine Corticosteroid COVID-19 patients criteria demonstrated Dexamethasone drug Effect hospitalized patient hospitalized patients hyperinflammation immunomodulators immunomodulatory activity Infection inferiority inhibitor interleukin 6 interleukin 6 receptor Janus kinase Kinase inhibitor Meta-analysis Microbiology Mortality no effect no effects outcome oxygen pathology Patient receptor receptor antagonist reducing Repurposed drug Repurposed drugs SARS-CoV-2 virus severe cases stages subgroups of patient supplementary oxygen survival the SARS-CoV-2 virus therapeutic dose Tocilizumab Treatment Trial Ventilation [DOI] 10.1111/1462-2920.15828 PMC 바로가기 [Article Type] Review
Retrospective cohort study to evaluate medication use in patients hospitalised with COVID-19 in Scotland: protocol for a national observational study스코틀랜드에서 COVID-19로 입원 한 환자의 약물 사용을 평가하기위한 후 향적 코호트 연구 : 국가 관찰 연구를위한 프로토콜Pharmacology and Therapeutics Published on 2021-11-192022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 치료제, [키워드] Administered Analysis approval board caused changes in choice clinical pharmacology clinical trials cohort study Committee COVID-19 death described description Dexamethasone dissemination Dose escalation drug East estimation Ethics evaluate Evidence example exploratory exposure to finding FIVE hospital hospitalisation hospitalisations hospitalised In-hospital Infection information knowledge medication Medicine Medicines National outcomes Panel Patient peer-reviewed platform Prevent Primary outcome privacy protocol Public real-world data receiving reduced risk Release Remdesivir Repurposed drug Research Ethics retrospective cohort study routine clinical practice SARS-COV-2 infection Scottish service severe COVID-19 South Surveillance switching Therapeutics Tocilizumab treated Treatment Vaccine website with COVID-19 [DOI] 10.1136/bmjopen-2021-054861 PMC 바로가기 [Article Type] Pharmacology and Therapeutics
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cellsArticle Published on 2021-11-122022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 binding ACE2 protein ACE2-expressing cells binding biochemical assay blocked Cell clinical common Concentration cystic fibrosis derivative digitoxin drug escaped glycoside hearts host receptor human lung cell human lung cells Hypothesis inhibit inhibiting inhibitor mechanism of action medication mink mutations original penetration Protein Proteins RBD RBD protein Repurposed drug Safe SARS-CoV-2 SARS-COV-2 infection spike subject target cells Target validation tested the SARS-CoV-2 the Spike therapy viral spike protein virus [DOI] 10.1038/s41598-021-01690-9 PMC 바로가기 [Article Type] Article
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive OverviewReview Published on 2021-11-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome applied approved clinical trials Comprehensive continuous monitoring Control coronavirus coronavirus disease COVID-19 COVID-19 pandemic drug Drug repurposing elicited Evolution global pandemic highlighting humans immune evasion immune response Intervention management modify mutated new strain outbreak pathogenicity Pharmaceutical interventions Pneumonia Prophylactic public health Repurposed drug repurposing respiratory respiratory tract infection resulting SARS-CoV-2 specific treatment therapeutic Vaccine Vaccines variant variants virus [DOI] 10.3390/vaccines9111317 PMC 바로가기 [Article Type] Review
Mucoadhesive nanoformulations and their potential for combating COVID-19Commentary Published on 2021-11-032022-10-30 Journal: Nanomedicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome combating COVID-19 Cytokine storm human angiotensin-converting enzyme II mucoadhesive Mucus Hypersecretion Nasal Sprays pulmonary delivery Repurposed drug SARS-CoV-2 spike glycoprotein [DOI] 10.2217/nnm-2021-0287 PMC 바로가기 [Article Type] Commentary
New Insights Into Drug Repurposing for COVID-19 Using Deep Learning딥 러닝을 사용하여 COVID-19에 대한 약물 용도 변경에 대한 새로운 통찰력Review Published on 2021-11-012022-09-11 Journal: IEEE transactions on neural networks and learning [Category] MERS, 신약개발, 치료제, [키워드] Accessibility Accuracy Activation adopted Algorithms approach approaches black box complex complex diseases coronavirus disease Coronavirus disease 2019 COVID-19 Critical deep deep learning develop disease Diseases drug effective effective drugs functions identify improvement Improvements insight interpretability learning New patients Precision referred to Repurposed drug Repurposed drugs repurposing Spread the disease transmitted treat treating COVID-19 Treatment treatment strategy [DOI] 10.1109/TNNLS.2021.3111745 PMC 바로가기 [Article Type] Review
Exploring the therapeutic potential of marine-derived bioactive compounds against COVID-19COVID-19에 대한 해양 유래 생리 활성 화합물의 치료 가능성 탐색Review Published on 2021-10-012022-09-11 Journal: Environmental science and pollution research inter [Category] SARS, 치료제, [키워드] anti-inflammatory properties antioxidant Antiviral antiviral properties antiviral property bioactive compounds Compound condition COVID-19 develop Drug development effective Halobiont immunomodulatory Marine-derived mode No effective drug ocean organism Organisms pharmacological Repurposed drug Repurposed drugs Sponge Symptom The therapeutic potential. the vaccine therapeutic potential these compounds Transmission virus [DOI] 10.1007/s11356-021-16104-6 PMC 바로가기 [Article Type] Review
High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main proteaseSARS-COV-2 메인 프로테아제를 대상으로하는 용도가 높은 약물의 고 처리량 스크리닝 및 평가Comment Published on 2021-09-292022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 치료제, [키워드] Drug screening protease Repurposed drug Target validation the SARS-CoV-2 [DOI] 10.1038/s41392-021-00763-5 PMC 바로가기 [Article Type] Comment
Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapiesResearch Published on 2021-09-202022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] anticancer antiviral drugs Antiviral effect applied approach AutoDock vina binding energy calculate Compound COVID-19 drug drug candidate Drug repurposing identify in vitro in vivo infected patients inhibitor molecular docking molecular dynamics Molecular dynamics simulation other coronaviruses potential therapy proportion RdRP receptor reported Repurposed drug repurposing RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown starting point supplementary material tested the SARS-CoV-2 therapy treating COVID-19 Trial tyrosine utility Virtual screening [DOI] 10.1186/s43556-021-00050-3 PMC 바로가기 [Article Type] Research