Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19 A Phase 2 Randomized Clinical Trial
경증에서 중등도의 COVID-19 A 2상 무작위 임상 시험에서 SARS-CoV-2 호흡기 바이러스 제거, 바이러스 배출 및 증상 지속 기간에서 니클로사미드 대 위약의 효능
Randomized Controlled Trial
[키워드] 1:1
95% CI
accounted
addition
adverse event
adverse events
age
All trial participants
analyzed
antiviral activity
assigned
blind
by mouth
calculated
center
Chain Reaction
Characteristics
clearance of SARS-CoV-2
clinical
clinical trial
confirmation
contagious period
cough
COVID
COVID-19
COVID-19 testing
decrease
determined by
diagnose
Duration
duration of symptom
Efficacy
enrolled
Enrollment
exclusion criteria
fecal
Fecal sample
finding
group
groups
headache
Headaches
Hospitalization
Importance
in vitro
individual
Infection
intention-to-treat
investigators
Laboratory
Massachusett
Massachusetts
mean difference
mean survival time
measure
men
Mild
mild to moderate
Mild to moderate COVID-19
mild to moderate symptoms
moderate
Moderate COVID-19
MONITOR
mouth
network
niclosamide
no significant difference
objective
oral
Oropharyngeal
participant
Participants
Patient
patients receiving placebo
Phase 2
Placebo
placebo group
placebo-controlled clinical trial
platform
Point
polymerase chain
polymerase chain reaction
positive
primary end point
proportion
Randomized
randomized clinical trial
Randomly
receive
receiving
Registration
Relevance
reported
respiratory
respiratory sample
Respiratory samples
Result
Safe
sample collection
Sample size
SAR-CoV-2
SARS-CoV-2
SARS-CoV-2 clearance
setting
shedding
significant effect
significantly
Standard of care
statistically
Symptom
symptom duration
symptom resolution
Symptoms
the placebo group
therapy
treat
Treatment
treatment for COVID-19
treatment groups
Trial
trial participants
Tuft
vaccination
Viral
viral clearance
viral shedding
was collected
[DOI] 10.1001/jamanetworkopen.2021.44942 PMC 바로가기 [Article Type] Randomized Controlled Trial
[DOI] 10.1001/jamanetworkopen.2021.44942 PMC 바로가기 [Article Type] Randomized Controlled Trial