Diagnosis of SARS-CoV-2 Infection with LamPORE, a High-Throughput Platform Combining Loop-Mediated Isothermal Amplification and Nanopore Sequencing루프 매개 등온 증폭과 나노포어 시퀀싱을 결합한 고처리량 플랫폼인 LamPORE를 사용한 SARS-CoV-2 감염 진단Virology Published on 2021-03-292022-09-10 Journal: Journal of Clinical Microbiology [Category] SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach clinical samples collected coronavirus Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostic sensitivity diagnostic specificity evaluated extracted RNA Genome Infection isothermal amplification LamPORE limit limit of detection Loop-mediated isothermal amplification Nanopore nanopore sequencing nose and throat offer Pathogens Patient per day platform produced reduction reproducibility respiratory respiratory pathogen respiratory sample reverse transcriptase reverse transcriptase PCR RNA RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity Sequencing severe acute respiratory syndrome Coronavirus specificity specimen specimens Swab symptomatic infection symptomatic patient Symptomatic patients throat swabs UK hospitals [DOI] 10.1128/JCM.03271-20 PMC 바로가기 [Article Type] Virology
Performance of Saliva Specimens for the Molecular Detection of SARS-CoV-2 in the Community Setting: Does Sample Collection Method Matter?커뮤니티 환경에서 SARS-CoV-2의 분자 검출을 위한 타액 표본의 성능: 샘플 수집 방법이 중요합니까?Article Published on 2021-03-192022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 진단, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ambulatory patient ambulatory patients Asymptomatic asymptomatic individual Asymptomatic individuals best coefficient collected Collection Community community setting conditions conducted confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold detection diagnosing diagnostics higher risk identify individual intervals median age Nasopharyngeal swab nasopharyngeal swabs NPs Oropharyngeal Outpatient outpatients pair Patient PCR performance positive primary care centers Prospective Study ranged respiratory reverse transcriptase reverse transcriptase PCR RT-PCR Saliva saliva samples saliva specimen saliva specimens Sample SARS-CoV-2 sensitivities sensitivity severe acute respiratory syndrome Coronavirus specimen symptomatic individual symptomatic individuals tested Transmission was performed [DOI] 10.1128/JCM.03033-20 PMC 바로가기 [Article Type] Article
A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York CityObservational Study Published on 2021-01-262022-10-04 Journal: Neurology [Category] 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age Care complications conducted coronavirus coronavirus disease COVID-19 COVID-19 symptom CSF determine Diabetic diagnose diagnosed discharge discharge home disorder Encephalopathy hazard ratio hospital Hospitalized hypertensive in-hospital mortality increased risk Injury Intubated intubation laboratory-confirmed SARS-CoV-2 infection likelihood male median medications Mortality multicenter neurologic neurologic disorder neurologic disorders New York City Older Organ failure outcomes Patient patients with COVID-19 Prevalence Prospective recorded reverse transcriptase PCR SARS-CoV-2 SARS-COV-2 infection Seizure Sex SOFA SOFA scores specimen stroke systemic illness was recorded [DOI] 10.1212/WNL.0000000000010979 PMC 바로가기 [Article Type] Observational Study
Performance Characteristics of the Vidas SARS-CoV-2 IgM and IgG Serological AssaysVidas SARS-CoV-2 IgM 및 IgG 혈청학적 분석의 성능 특성Immunoassays Published on 2021-01-082022-09-10 Journal: Journal of Clinical Microbiology [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays automated caused clinical clinical sensitivity clinical specificity coefficients Combined coronavirus COVID-19 COVID-19 pandemic cross-reactivity declined Diagnosis Emergency use authorization epidemiological epidemiological surveillance healthy donor Hospitalized IgG IgG responses IgM and IgG IgM/IgG immunoserology Infection pandemic Patient patients performance positive Precision reached remained respiratory respiratory virus response reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-CoV-2 infections SARS-CoV-2 patients SARS-CoV-2 PCR SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitivity sera Seroconversion Serological assay serological assays serological test Serological testing Serological tests significantly higher specific IgM specificity Spread Surveillance symptom onset test results Variation Vidas virus infection was determined [DOI] 10.1128/JCM.02292-20 PMC 바로가기 [Article Type] Immunoassays
Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2HIV-1에서 SARS-CoV-2로의 고급 임상 바이러스 분석 적응Review Published on 2021-01-012022-09-11 Journal: Current opinion in HIV and AIDS [Category] 치료기술, [키워드] adaptation analyses antiviral therapeutics applied approaches Blood conserved COVID COVID-19 pandemic disease severity Evidence genetic diversity Genetic variation HIV-1 HIV-1 infection IMPROVE infected individual infected individuals knowledge molecular Neutralizing antibodies nucleic acid outcome pandemic Pathogenesis Phylogenetic analysis plasma Precision Prognosis recent reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 sequencing sensitive sequence Sequencing shown small molecule small molecule inhibitor Small molecule inhibitors Stage susceptibility therapy Vaccines Viral viral replication Viral RNA viral RNA quantification [DOI] 10.1097/COH.0000000000000656 PMC 바로가기 [Article Type] Review
Pooling samples: a testing option for SARS-CoV-2 during a supply shortageArticle Published on 2021-01-012023-07-02 Journal: Diagnostic microbiology and infectious disease [Category] SARS, [키워드] COVID-19 Molecular diagnosis reverse transcriptase PCR Sample pooling SARS-CoV-2 [DOI] 10.1016/j.diagmicrobio.2020.115205 PMC 바로가기
Acute pericarditis and severe acute respiratory syndrome coronavirus 2: Case report급성심낭염과 중증급성호흡기증후군 코로나바이러스 2: 증례보고Case Reports Published on 2020-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Acute pericarditis acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 blood cell C-reactive protein Chest computed tomography chest computed tomography scan chest pain Computed tomography coronary angiogram coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dominant echocardiography electrocardiogram elevated emergency department erythrocyte sedimentation erythrocyte sedimentation rate ground-glass opacity Infection interleukin interleukin 6 Laboratory test Laboratory tests lower lobe lymphocytopenia Myocardial infarction Nasopharyngeal swab neutrophilia nucleic acid outbreak Patient pericardial effusion Pericarditis positive respiratory reverse transcriptase reverse transcriptase PCR right lower lobe SARS-CoV-2 SARS-COV-2 infection sedimentation rate severe acute respiratory syndrome Coronavirus White blood cell zone [DOI] 10.1016/j.ijid.2020.09.1440 PMC 바로가기 [Article Type] Case Reports
Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case SeriesResearch Article Published on 2020-11-112022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] activated acute phase acute respiratory syndrome adaptive Antibody Response assessment CD14 CD16 cellular characterized coronavirus correlation CoV COVID-19 Culture cytokine cytokine response Cytokines Daily detectable develop disease FIVE high viral load humoral Immune profile immune response Immunity immunology increases in Infection Infectious virus Innate innate response Isolation Kinetics Mild mild symptoms monocyte onset of symptoms Patient patients peaked resolution of symptoms respiratory tract response responses reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2-specific antibodies Sery subjects Switzerland symptom onset the disease viral control Viral load Viral RNA virus with mild disease [DOI] 10.1128/mSphere.00827-20 PMC 바로가기 [Article Type] Research Article
Evaluation of pooled sample analysis strategy in expediting case detection in areas with emerging outbreaks of COVID-19: A pilot study신종 코로나바이러스 감염증(COVID-19) 발병 지역에서 사례 발견을 촉진하기 위한 통합 샘플 분석 전략 평가: 파일럿 연구Research Article Published on 2020-09-222022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] adoption Analysis applicability blinded Characteristics choice consecutive sample COVID-19 Ct value Diagnosis diagnosis of COVID-19 diagnostic diagnostics disease outbreak effective emerging disease evaluated impair infected individual infected individuals Isolation Laboratory lead nasopharyngeal Negative predictive value Oropharyngeal outbreak pilot study point prevalence pool positive positive sample Predictive value Presence Prevalence qRT-PCR Quantitative reduced reported reverse transcriptase reverse transcriptase PCR technique tested time-consuming transmission of SARS-CoV-2 while [DOI] 10.1371/journal.pone.0239492 PMC 바로가기 [Article Type] Research Article
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis무증상 및 무증상 SARS-CoV-2 감염의 발생 및 전파 가능성: 살아있는 체계적인 검토 및 메타 분석Research Article Published on 2020-09-222022-08-13 Journal: PLoS Medicine [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] 95% CI 95% confidence interval accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed ascertainment Asymptomatic Asymptomatic individuals asymptomatic infection asymptomatic infections attack rate automated biases bioRxiv Case series certainty Combination conducted Contact coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 symptom COVID-19 symptoms credibility database defined determine develop diagnosed disagreement estimate Evidence extraction False negative Follow-up Future heterogeneity hygiene include individual infected with SARS-CoV-2 Infection infectiousness Isolation less limit limitation Masks measure Measures medRxiv Meta-analysis negative RT-PCR participant Population presymptomatic Prevent proportion question Relative risk remained researcher resolved respiratory resulting reverse transcriptase reverse transcriptase PCR risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 transmission screened searched secondary attack rate Seven severe acute respiratory syndrome Coronavirus social distancing Study design study participant Study participants Symptom symptom status symptomatic infection systematic review Transmission transmission potential were assessed [DOI] 10.1371/journal.pmed.1003346 PMC 바로가기 [Article Type] Research Article