Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster ModelsArticle Published on 2022-04-012023-07-08 Journal: Toxicologic pathology [Category] COVID19(2023년), [키워드] animal models hamster Pneumonia rhesus macaque SARS-CoV-2 [DOI] 10.1177/01926233211072767 PMC 바로가기
Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque붉은 털 원숭이에서 SARS-CoV-2의 델타 변이체의 감염 및 발병 기전Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] delta variant disease severity disease spread faster infect Pathogenesis rhesus macaque SARS-CoV-2 shedding Support Viral load Wuhan [DOI] 10.1016/j.virs.2022.02.001 PMC 바로가기 [Article Type] Article
In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료Article Published on 2022-04-012022-09-11 Journal: Human gene therapy [Category] COVID19(2023년), SARS, 변종, [키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin [DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article
Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants spike tomography vaccination Vaccine virus load [DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
Ultrastructural characterization of host-parasite interactions of Plasmodium coatneyi in rhesus macaquesarticle Published on 2022-02-282024-09-01 Journal: Parasitology [Category] 말라리아, [키워드] malaria Plasmodium coatneyi Plasmodium falciparum rhesus macaque sequestration ultrastructure [Article Type] article
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques히말라야 원숭이에서 SARS-CoV-2 감염 후 면역 및 질병 매개변수에 대한 에어로졸 전달 BCG 백신의 영향Immunology Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome adaptive aerosol Aerosol BCG vaccination antibody Antibody-mediated immunity antiviral immune response applied bacille Calmette-Guérin BAL BCG BCG vaccination Bronchoalveolar lavage cell-mediated immune response cellular challenge chemokine Classical CD14+ monocyte Classical CD14+ monocytes clearance collected comparable Concentration contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease severity cross-protection cross-protective cross-reactive cytokine disease disease pathology disease severity early disease ENhance exceeded groups Heterologous High dose Histopathology Humoral immunity hypothesised immune cells immune mechanism immune response immune responses immune signature Immunity immunological parameters indicated induce Infection influence initial innate immune innate immune cell Innate immune cells Innate immunity Intervention intrabronchial intranasal macaque macaques marker mechanism Monocytes nasal nasal and pharyngeal swabs natural infection non-specific Occurrence parameter pharyngeal populations primary site priming quantified reduce respiratory respiratory pathogen rhesus macaque rhesus macaques SARS-CoV-2 secretion severe acute respiratory syndrome Coronavirus subsequent susceptible swabs T-cell T-cells the disease tissue tissue sample titre titres trained immunity Tuberculosis tuberculosis vaccine Vaccine Viral Viral RNA virus [DOI] 10.3389/fimmu.2021.801799 PMC 바로가기 [Article Type] Immunology
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2골수 세포 인터페론 반응은 SARS-CoV-2 제거와 관련이 있습니다Article Published on 2022-02-032022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] accumulation ACE2 angiotensin angiotensin-converting enzyme 2 Anti-viral appearance BAL baseline Bronchoalveolar lavage CD163 CD68 Cell cell suspension changes in clearance of SARS-CoV-2 correlated COVID-19 patients COVID-19-related death dendritic cells emergence exhibiting expressing expression gene signature heterogeneous HLADR host response host responses Human immune Immune cell immune profiling immunopathology increased risk individual cells infected with SARS-CoV-2 Infection Inflammation Inflammatory Innate immunity interferon interferon response lung Lungs macaque macaques Macrophage macrophages Mutant SARS-CoV-2 myeloid observé plasmacytoid dendritic cell plasmacytoid dendritic cells Population reported response rhesus macaque rhesus macaques RNAseq SARS-CoV-2 SARS-COV-2 infection scRNAseq SIGLEC1 significantly Single Cell strain T-lymphocyte T-lymphocytes transcriptional transcriptional change Transcriptional changes Type type I interferon type I interferon response Viral viral clearance viral dynamics viral infection Viremia while [DOI] 10.1038/s41467-022-28315-7 PMC 바로가기 [Article Type] Article
Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variantsSARS-CoV-2 WA1/2020에 대한 이전 감염은 B.1.1.7 및 B.1.351 변이체에 의한 재감염으로부터 붉은털 원숭이를 부분적으로 보호합니다.Article Published on 2022-02-032022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] (alpha (Beta acute respiratory syndrome acute respiratory syndrome coronavirus Alpha B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants coronavirus Critical Efficacy high viral replication Immunity implication Infection infection with SARS-CoV-2 leads Lower respiratory tract natural natural immunity Neutralizing antibodies neutralizing antibody PROTECT Protective public health question Reinfection respiratory rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WA1/2020 strain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the SARS-CoV-2 These data Transmissibility upper and lower respiratory tract vaccination variant variants Viral WA1/2020 [DOI] 10.1126/scitranslmed.abj2641 PMC 바로가기 [Article Type] Article
Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2렘데시비르 피하 투여로 SARS-CoV-2 접종한 붉은털원숭이의 간질성 폐렴 예방Article Published on 2022-02-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] absence administer administration animal animal model Antiviral caused COVID-19 COVID-19 patient disease Efficacy hospitalized patients in vivo inoculated interstitial pneumonia intravenously Lower respiratory tract lower respiratory tract disease macaque macaques post inoculation Prevent PROTECT reduced reduction Remdesivir Respiratory disease rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection Subcutaneous subcutaneous administration tested treated Treatment utility virus virus replication [DOI] 10.1016/j.antiviral.2022.105246 PMC 바로가기 [Article Type] Article