Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics입장 금지!SARS-COV-2 진입 억제제 : COVID-19 Therapeutics로서의 역할과 유용성Review Published on 2021-07-232022-09-01 Journal: Virology Journal [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antigenic antigenic drift approval best COVID-19 COVID-19 pandemic COVID-19 therapeutics effective effective vaccine Emerging sarbecoviruses globe Health healthcare herd immunity highlight Immunity individual inhibitor Keep less life management mechanism of action Mild miniprotein Mortality Mutation Neutralizing antibodies neutralizing antibody new SARS-CoV-2 pandemic Population Prophylaxis recombinant ACE2 Sarbecoviruses SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 variants significantly the vaccine Therapeutic strategies therapeutic strategy utility vaccinate Vaccine Vaccines variant Viral viral entry Viral entry inhibitors zoonotic sarbecoviruses [DOI] 10.1186/s12985-021-01624-x PMC 바로가기 [Article Type] Review
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains Coronavirus sequences RaTG13, MP789 and RmYN02 raise multiple questions to be critically addressed by the scientific communitySARS-CoV-2의 천연 기원은 관련 균주의 게놈 서열 문제로 인해 훼손됨Think Again Published on 2021-05-272022-09-10 Journal: Bioessays [Category] 변종, [키워드] addressed Amino acid amino acid insertion Analysis claimed Contamination coronavirus Critical dataset Features furin furin cleavage site Genome genome sequence insertion metagenomic nucleotide open origin pandemic Pangolin CoV MP789 peer review polybasic PRRA insertion question raise RaTG13 reveal RmYN02 S1/S2 junction Sarbecoviruses SARS‐CoV‐2 SARS‐CoV‐2 Scientific community sequence Sequencing Spike protein strain Strains Support unique [DOI] 10.1002/bies.202100015 PMC 바로가기 [Article Type] Think Again
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection교차 중화 항체의 조합은 SARS-CoV-2 및 SARS-CoV 슈도바이러스 감염을 예방하기 위해 상승합니다.Article Published on 2021-05-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] 3D structure Abstract antibodies antibody antibody cocktail antibody-antigen interaction antigenic antigenic drift antigenic variation B.1.1.7 B.1.351 bind bound waters caused circulating variant circulating variants Combination complex conserved coronavirus coronavirus disease Coronavirus disease 2019 COVA1-16 COVID-19 COVID-19 patient CR3022 cross-neutralizing cross-neutralizing antibodies cross-neutralizing antibody cross-react cross-reactivity crystal structure crystal structures Crystallography Effectiveness ENhance Epidemics facilitate glycan glycosylation site Infection information interact Interaction neutralization neutralize Neutralizing antibodies Pandemics Prevent PROTECT provide receptor-binding domains Recognition related viruses S309 Sarbecoviruses SARS-CoV SARS-CoV pseudovirus SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronaviruses SARS-related virus SARS-related viruses shown spike spikes Structure synergy the receptor-binding domain therapeutic therapeutic antibodies these viruses threat Threats Vaccine viruses X-ray zoonotic [DOI] 10.1016/j.chom.2021.04.005 PMC 바로가기 [Article Type] Article
Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen박쥐에서 SARS-CoV-2의 진화에서 자연 선택은 일반 바이러스와 고도로 유능한 인간 병원체를 만들었습니다Research Article Published on 2021-03-122022-08-13 Journal: PLoS Biology [Category] Biology and Life Sciences, Fulltext, SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술, [키워드] accompanied acting acute respiratory syndrome coronavirus adaptive Analysis ancestor Anti-viral Antiviral base bat bat Sarbecovirus bats can not Cell Coinfection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CpG CpG composition detect early phase Evidence evidence of Evolution Evolution of SARS-CoV-2 horseshoe bats Host hosts Human human pathogen humans include involved Lineage lineages mechanism moderate natural natural selection nucleotide nucleotides pandemic positive Positive selection progenitor recombinant Recombination required respiratory reveal RmYN02 Sarbecoviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support the cells the early SARS-CoV-2 Transmission virus viruses while [DOI] 10.1371/journal.pbio.3001115 PMC 바로가기 [Article Type] Research Article
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibodyResearch Article Published on 2021-02-192022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, MERS, [키워드] acute respiratory syndrome addition administration against SARS-CoV antibodies antibody approach bats binding binding activity biochemical clade Complete conserved coronavirus coronavirus COVID-19 COVID-19 pandemic CoVs Efficacy Epidemic epitope Evolution Human Human monoclonal antibody in vivo Lung pathology Lungs mouse model Mouse models murine model neutralization breadth neutralize neutralized overlap pathogenic coronavirus progeny Prophylactic provided Receptor binding domain receptor binding site recognize sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-like virus SARS-related virus Science screened survivor targeting the receptor-binding domain therapeutic variants viral replication yeast zoonotic spillover [DOI] 10.1126/science.abf4830 PMC 바로가기 [Article Type] Research Article
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteinsSARS-CoV-2 스파이크 단백질의 다량체화 및 글리코실화 의존성 수용체 결합Research Article Published on 2021-02-082022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, [키워드] ACE2 expression adherent Author benefit binding binding affinity bronchiolar duct bronchiolar ducts candidate cell line cell lines cells complex complex glycosylated protein COVID19 demonstrated determine domain domains fluorescent fluorescent multimeric RBD proteins glycosylated glycosylated RBD glycosylation GnTI-/- mutant cells HEK293T increase mannose mannose glycosylation MONITOR monomeric monomeric and trimeric fluorescent RBD proteins mutant cells native viruses pandemic profile profiles Protein RBD RBD protein RBD proteins Receptor binding recombinant spike proteins respiratory respiratory tissue respiratory tissues sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike protein Spike proteins these viruses tissues toolkit trimer trimeric trimeric fully glycosylated RBD trimers trimeric RBD protein variants virus viruses were stained zoonotic [DOI] 10.1371/journal.ppat.1009282 PMC 바로가기 [Article Type] Research Article