A systematic review and meta-analysis on chloroquine and hydroxychloroquine as monotherapy or combined with azithromycin in COVID-19 treatment코로나19 치료에서 클로로퀸과 하이드록시클로로퀸 단독요법 또는 아지스로마이신과의 병용요법에 대한 체계적인 검토 및 메타분석Meta-Analysis Published on 2020-12-172022-09-10 Journal: Scientific Reports [Category] SARS, 임상, 치료법, 치료제, [키워드] 95% CI 95% confidence interval Analysis article Azithromycin calculated can not carried Chain Reaction Chloroquine CIs Combination coronavirus COVID-19 cure rate database Diseases drug side effects Effect Effectiveness examined exposure to Future good quality group HCQ Hospital stay Hydroxychloroquine IMPROVE Infectious diseases investigated mechanical ventilation Meta-analysis meta-regression monotherapy Mortality mortality rate not differ not different observational studies observational study Patient PCR polymerase chain polymerase chain reaction radiological improvement radiological progression random-effects model randomized control trial RCT relative risks reported risk RRs scarcity side Side effects significantly significantly higher standard care statistically systematic review treating COVID-19 Treatment Viral viral infection was performed worsening [DOI] 10.1038/s41598-020-77748-x PMC 바로가기 [Article Type] Meta-Analysis
Repurposing Anti-Cancer Drugs for COVID-19 TreatmentCOVID-19 치료를 위한 항암제의 용도 변경Review Published on 2020-11-182022-08-31 Journal: Drug design, development and therapy [Category] 신약개발, 임상, 치료제, [키워드] adverse event adverse events allergy anti-cancer drugs benefit Cancer catastrophic caused Cell cell division center clinical trials compassionate use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 de novo died drug Drug development Drug discovery drug-repurposing. effective drug effective drugs Efficacy effort FDA focus food Food and Drug Administration globe hospitalized COVID-19 patients Host Infectious disease Infectious diseases Inflammation inhibiting Johns Hopkins Johns Hopkins University life microenvironment modulating NIAID Novel coronavirus novel coronavirus disease novel vaccines pandemic present promise randomized study Remdesivir repurposing scarcity shown tested the disease Therapies Treatment Vaccine Vaccines [DOI] 10.2147/DDDT.S282252 PMC 바로가기 [Article Type] Review
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease SeverityArticle Published on 2020-11-122022-10-04 Journal: Cell [Category] Fulltext, SARS, 유전자 메커니즘, [키워드] acute COVID-19 adaptive Adaptive immune response Adaptive immunity aging antibody Antibody Response Arm Biomarker CD4 CD8 connection convalescent coronavirus COVID-19 COVID-19 disease severity CXCL10 disease disease severity Epitopes highlighting identify immune response Immunity individual IP-10 knowledge limit Limited Multiple Neutralizing antibodies Neutralizing antibody response outcomes Protective protective immunity response responses risk factor SARS-CoV-2 scarcity severe COVID-19 spike subjects T cells [DOI] 10.1016/j.cell.2020.09.038 PMC 바로가기 [Article Type] Article
Decisions on the allocation of intensive care resources in the context of the COVID-19 pandemic Clinical and ethical recommendations of DIVI, DGINA, DGAI, DGIIN, DGNI, DGP, DGP and AEMGuidelines and Recommendations Published on 2020-07-292022-10-30 Journal: Medizinische Klinik, Intensivmedizin Und Notfallme [Category] Coronavirus, MERS, SARS, [키워드] addition age approach clinical Comorbidity coronavirus disease COVID-19 COVID-19 pandemic criteria criterion death decision eight Evidence Factors general health status Gerechtigkeit hospital include intensive care Intensive care medicine Intensivmedizin Justice pandemic Patient Perspective preference Priorisierung Prioritisation recommendation resource resources Ressourcenmangel scarcity severity supplementary material Support Treatment Triage [DOI] 10.1007/s00063-020-00709-9 PMC 바로가기 [Article Type] Guidelines and Recommendations
Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples임상 샘플에서 직접 SARS-CoV-2 게놈의 대규모 병렬 시퀀싱을 위한 여러 접근 방식Research Published on 2020-06-302022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, [키워드] (coronavirus disease 2019 Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amplicon amplicon method Amplicon sequencing analyses Analysis applied approach approaches best capture capture method caused Characteristics clinical sample clinical samples Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured isolate demonstrated diagnostics Dilution Efficiency eight Emerging infectious diseases Epidemic Epidemiology Evolution examined Factor full-length SARS-CoV-2 genetic information Genome Genome sequencing genomes Genomic surveillance Guidance Hybrid capture inter- and intra-individual variations inter-individual inter-individual and intra-individual variations intra-host dynamics intra-individual variation iSNV knowledge Metatranscriptomic sequencing Multiple Multiplex PCR novel multiplex PCR amplicon offer PCR amplicon Quasispecies reported respiratory Result SARS-CoV-2 SARS-CoV-2 genome scarcity sensitivity Sequencing severe acute respiratory syndrome Coronavirus Therapeutics ultra-high-throughput metatranscriptomic variations Viral Viral load viral loads viral read Viral transmission virus Virus evolution Virus-host interaction Virus-host interactions viruses whole-genome sequencing [DOI] 10.1186/s13073-020-00751-4 PMC 바로가기 [Article Type] Research
Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans단성 생식은 세계적인 인간 곰팡이 병원균인 Cryptococcus deneoformans에서 짝짓기 파트너를 위한 경쟁을 촉진합니다Research Article Published on 2019-09-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Activation assays benefit bisexual reproduction Cell Cell fusion cell-cell fusion cells colonies colony competing competition complex Contact contribute Courtship Cryptococcus Cryptococcus neoforman Cryptococcus neoformans Diversity ecological Efficiency ENhance enhanced facilitate followed by foraging fungal fungal pathogens Genome growth hyphae hyphal isolate isolates lack life cycle majority MAT a MAT α mating mating type mating types mechanism meiotic recombination Morphological nuclear nuclear fusion nuclei opposite outcrossing pathogen Pathogens pathway pheromone positively correlated prevalent promote promoted Quantitative reflect repressor gene scarcity sexual cycles sexual reproduction strain Strains surface area undergo yeast [DOI] 10.1371/journal.pgen.1008394 PMC 바로가기 [Article Type] Research Article