Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized TrialResearch Article Published on 2021-11-152022-10-31 Journal: Canadian Respiratory Journal [Category] COVID-19, SARS, [키워드] Acute respiratory infection adverse event AEs Antibiotics antibody Antiviral ARI being CD4 children clinical trial Combination disease double-blind effective Effectiveness Efficacy and safety evaluate Fever Frequency IMPROVE incidence increase Infant Infectious disease intention-to-treat analysis interferon gamma International Mild moderate modulate molecular target Month multicenter nonspecific oral temperature outcome measure outcomes Outpatient parallel-group Patient patients Placebo placebo group placebo-controlled Randomized Rash recovered patients reduced respiratory Safety Secondary endpoints severity significantly lower Symptom symptom severity score symptomatic Symptoms the mean the patient the placebo group the primary endpoint therapy time Treatment virus was performed Year [DOI] 10.1155/2021/5570178 PMC 바로가기 [Article Type] Research Article
Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in an outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial evaluating viral clearance외래 환자 환경에서 경증 COVID-19의 하이드록시클로로퀸과 아지스로마이신 조기 치료: 바이러스 제거를 평가하는 무작위, 이중 맹검, 위약 대조 임상 시험Randomized Controlled Trial Published on 2021-11-012022-09-11 Journal: International journal of antimicrobial agents [Category] 임상, 치료법, 치료제, [키워드] 95% CI adverse effects Analysis Azithromycin cardiovascular event Chest computed tomography clearance rate clinical evolution Comorbidities Computed tomography conducted Controlled clinical trial COVID-19 criteria demographic characteristics double-blinded early treatment Efficacy Endpoint enrolled enrolment evaluated Evolution group Hospitalization Hydroxychloroquine hydroxychloroquine plus azithromycin in some in viral In vitro studies inclusion criteria intention-to-treat Mild mild SARS-CoV-2 infection outcome Outpatient outpatients participant Patient per-protocol performed Placebo placebo-controlled clinical trial POCT positive PP analysis primary endpoint randomised Randomized RCT reducing SARS-CoV-2 SARS-COV-2 infection screening test secondary Secondary endpoints Secondary outcomes shown significantly statistical analyses statistically significant Support Swab Symptom Treatment trial participants viral clearance viral clearance rate viral clearance rates Viral load viral load reduction viral loads viral replication [DOI] 10.1016/j.ijantimicag.2021.106428 PMC 바로가기 [Article Type] Randomized Controlled Trial
All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohortOriginal Paper Published on 2021-10-082022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), SARS, [키워드] age all-cause mortality analyses Analysis analyzed antibiotic antibiotic stewardship Antibiotic therapy Antibiotic treatment antibiotic use Antibiotics Bacterial calculated Cohort Comorbidity confounder coronavirus disease correlation COVID-19 COVID-19 patients Critical disease Disease progression Effect Gender had no IMPROVE inclusion criteria LEOSS less Local Mortality not correlated Patient PCT positive primary endpoint Probability procalcitonin progression reported Result SARS-CoV-2-infected patient Secondary endpoints significantly significantly increased the primary endpoint treated [DOI] 10.1007/s15010-021-01699-2 PMC 바로가기 [Article Type] Original Paper
Anaesthesia protocol evaluation of the videolaryngoscopy with the McGrath MAC and direct laryngoscopy for tracheal intubation in 1000 patients undergoing rapid sequence induction: the randomised multicentre LARA trial study protocol빠른 시퀀스 유도를 받는 1000명의 환자에서 McGrath MAC을 사용한 비디오 후두경 및 기관 삽관을 위한 직접 후두경의 마취 프로토콜 평가: 무작위 다기관 LARA 시험 연구 프로토콜Article Published on 2021-10-062022-09-11 Journal: BMJ Open [Category] SARS, 임상, 치료기술, [키워드] 90% power adult anaesthesia adult intensive & adverse events airway airway management anaesthesia approved aspiration chance consecutive patients Controlled trial COVID-19 pandemic Critical Critical care cuff direct laryngoscopy endotracheal tube Ethics expected glottis healthcare worker high risk include increased risk indicated Intensive International intubation Local local Ethics Committee Macintosh manuscript medical association multicentre National opening Patient percentage primary endpoint Protective protocol pulmonary aspiration randomised randomised controlled trial Randomly Rapid Rapid sequence induction reduce registration number Rhineland score secondary endpoint Secondary endpoints sequence significance level Study protocol surgery surgical technique the primary endpoint tracheal tracheal intubation Trial university videolaryngoscopy Visualisation [DOI] 10.1136/bmjopen-2021-052977 PMC 바로가기 [Article Type] Article
PRO B: evaluating the effect of an alarm-based patient-reported outcome monitoring compared with usual care in metastatic breast cancer patients—study protocol for a randomised controlled trialPRO B: 전이성 유방암 환자에서 일반 치료와 비교하여 경보 기반 환자 보고 결과 모니터링의 효과 평가 - 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-09-282022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 acute disease alarm among others approach ARMS Breast cancer breast cancer patient clinical Clinical practice Complete Contact control arm Controlled trial controls determined by develop disease domain elongation emergency room Endpoint enrolment ePROs fatigue female form Health apps hospitalisation hospitalisations identify include independent intervene Intervention intervention arm intervention group less life Metastatic breast cancer metastatic disease mobile devices outcome Patient Patient-reported outcomes Personalised medicine positive Primary outcome pros protocol Quality of life randomisation randomised randomised controlled trial receive recruited reported symptom reported symptoms required Research secondary Secondary endpoints selected Society supplementary material survival the patient transfer Treatment Trial Trigger usual care Value-based health care [DOI] 10.1186/s13063-021-05642-6 PMC 바로가기 [Article Type] Study Protocol
Prophylactic potential of honey and Nigella sativa L. against hospital and community-based SARS-CoV-2 spread: a structured summary of a study protocol for a randomised controlled trial병원 및 지역사회 기반 SARS-CoV-2 확산에 대한 꿀과 Nigella sativa L.의 예방 가능성: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-152022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 adaptive allergy analyst approved asymptomatic patient blinded Blinding body weight Botany Care care providers chronic infection clinic clinical Clinical management clinical study clinical trial college Community conflict conflict of interest control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19-related symptom COVID-19-related symptoms death defined dextrose dissemination doctor Efficacy element Endpoint enrolled evaluate excluded exposure to Final futility high risk Honey hospital hospitalizations incidence include institutional review board Intention interim analysis investigator management guidelines masking moderate National Health Service Nigella Nigella Sativa number objective outcome Pakistan parallel group participant Participants Patient patients per day Placebo placebo group placebo-controlled Primary outcome principal investigator Prophetic Medicine Prophylactic protocol randomisation randomised randomised controlled trial randomization Randomized receive recruited recruitment Registered reported responsible risk Sample size SARS-CoV-2 screened secondary Secondary endpoints severity Site Standard standard care Standardization status Stratification Study protocol supplementary material the patient therapeutic potential therapy Trial university Version water website [DOI] 10.1186/s13063-021-05510-3 PMC 바로가기 [Article Type] Letter
Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19초기의 후기 회복기 혈장은 중등도에서 세상에서 더 나은 생존과 관련이 있습니다.Research Article Published on 2021-07-282022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] addressed administration administration of CCP Analysis CCP CCP administration Cohort Complete conducted convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19 infection days alive discharge disease Endpoint Follow-up had more hospital hospital discharge Hospital mortality Hospital stay IMPROVE in-hospital mortality Inpatient investigated likelihood Limited mechanical ventilation median moderate-to-severe COVID-19 Mortality on mechanical ventilation outcome Patient plasma primary endpoint primary endpoints Propensity score question receive recipient recipients Research question Result secondary Secondary endpoints Study design survival therapeutic therapeutic option transfused trials ventilator WHO [DOI] 10.1371/journal.pone.0254453 PMC 바로가기 [Article Type] Research Article
Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trialCOVID-19로 인한 저산소성 호흡 부전 환자에서 깨어 난 위치Randomized Controlled Trial Published on 2021-06-142022-08-13 Journal: Critical Care [Category] MERS, 임상, [키워드] 30-Day mortality 95% CI Adult patient Adult patients adverse events assigned Awake prone positioning conducted control group COVID-19 Critical care did not reduce eligibility Endotracheal intubation Endpoint Enrollment futility groups High-flow nasal oxygen hospital hypoxemic Hypoxemic respiratory failure implemented protocol intensive care Intubated intubation intubation rate Intubation rates mechanical ventilation moderate to severe multicenter Noninvasive ventilation organ support oxygen PaO Patient patients with moderate per day pressure sore pressure sores primary endpoint prone group prone positioning protocol Randomized randomized clinical trial Randomly reduce respiratory Respiratory failure Respiratory Support Result secondary Secondary endpoints secondary outcome Secondary outcomes standard care supplementary material Trial Trial registration two patients Ventilator-free days [DOI] 10.1186/s13054-021-03602-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19)Randomized Controlled Trial Published on 2021-06-012022-10-04 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] acute respiratory syndrome administration Admission age alveolar epithelium angiotensin angiotensin-converting enzyme 2 Apoptosis Brazil cells Characteristics Chest computed tomography clinical Comorbidities conducted coronavirus coronavirus disease COVID-19 Department determine disease severity double-blind Emergency Endotracheal intubation Endpoint enrolled Evolution Gas exchange group groups High dose homeostasis ICU inactivation increase in induce Inflammation intensive care Laboratory test Local mechanical ventilation Medicine Mortality NAC no significant difference not affect oxyhemoglobin saturation Patient patients with COVID-19 placebo-controlled Pneumonia primary endpoint Randomized receive Redox imbalance registry respiratory Respiratory failure respiratory rate SARS-CoV-2 secondary Secondary endpoints severe COVID-19 Sex single-center suppress the placebo group Trial [DOI] 10.1093/cid/ciaa1443 PMC 바로가기 [Article Type] Randomized Controlled Trial
What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak토실리주맙은 어떻습니까? COVID-19 발생 기간 동안 NYC 병원의 후향적 연구Randomized Controlled Trial Published on 2021-04-082022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, [키워드] 7-point ordinal scale 95% CI absence Admission Bacterial infection Bacterial infections bacterial superinfection bacterial superinfections baseline Control Corticosteroid Corticosteroids COVID-19 COVID-19 outbreak demographics Endpoint evaluated Evidence evidence of gastrointestinal perforation Health hospital Hypoxemia Illness severity incidence include increase in independent independent of inflammatory phase interleukin-6 interleukin-6 receptor large academic medical center measure Methylprednisolone New York City no evidence of no increase Ordinal Scale outcome Oxygenation Patient patients with COVID-19 primary endpoint primary endpoints Primary outcomes receiving receptor blocker Result Retrospective analysis Retrospective study secondary secondary bacterial infection Secondary bacterial infections Secondary endpoints severe disease Support t-test Tocilizumab ventilator ventilator free survival ventilator-free survival [DOI] 10.1371/journal.pone.0249349 PMC 바로가기 [Article Type] Randomized Controlled Trial