BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: a prospective, single-centre, longitudinal cohort study in health-care workersBNT162b2 COVID-19 백신과 체액성 면역 반응 및 역학의 상관 관계: 의료 종사자를 대상으로 한 전향적, 단일 센터, 종단 코호트 연구Observational Study Published on 2021-09-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 95% CI abrogated administration age analyses anti-SARS-CoV-2 IgG antibody antibody concentration antibody kinetics Antibody Response Antibody test Autoimmune disease baseline BNT162b2 BNT162b2 vaccine breakthrough infections center Comorbidities Comorbidity concurrent correlation COVID-19 vaccine diabete disease domain dose elicited eligible Endpoint first dose Follow-up greater health-care high correlation highlighting humoral immune response hypertension IgA IgG IgG antibody IgG response IgM Immunosuppressed Immunosuppression individual individuals induce infection with COVID-19 initiated intramuscular linear mixed model linear regression analyses Logistic longitudinal cohort study Male sex Ministry of Health neutralisation neutralisation titre neutralising antibody neutralising antibody response neutralising antibody titres neutralising assay Older Older age over participant Participants Pfizer-BioNTech Population positive positive SARS-CoV-2 PCR receiving reduced regression analysis responses robust Scatter plot second dose second vaccination serological serology test serum sample significantly lower study population susceptible tested the receptor-binding domain the vaccine titre vaccination Vaccine vaccine dose were excluded were used [DOI] 10.1016/S2213-2600(21)00220-4 PMC 바로가기 [Article Type] Observational Study
An Immunogenicity Report for the Comparison between Heterologous and Homologous Prime-Boost Schedules with ChAdOx1-S and BNT162b2 VaccinesArticle Published on 2021-08-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI Administered antibody AstraZeneca BNT BNT162b2 ChAdOx1-S covariate COVID-19 COVID-19 vaccine France geometric healthcare worker Heterologous homologous homologous schedule hospital humans IgG antibody immune response immunogenicity immunological mRNA negative correlation no significant difference of BNT162b2 outcome participant Pfizer/BioNTech remained report robust SARS-CoV-2 IgG antibodies schedule second dose second vaccination serology test serum significantly higher vaccination vaccination schedule Vaccinations Vaccine vaccine group viral vectored vaccines [DOI] 10.3390/jcm10173817 PMC 바로가기 [Article Type] Article
SARS-CoV-2 IgG response in symptomatic and asymptomatic COVID-19-infected healthcare workers코로나19에 감염된 유증상 및 무증상 의료 종사자의 SARS-CoV-2 IgG 반응Article Published on 2021-08-202022-09-11 Journal: Occupational medicine (Oxford, England) [Category] MERS, SARS, 진단, 치료기술, [키워드] accounted affected age analysed anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies antibody Asymptomatic COVID-19 COVID-19 COVID-19 infection COVID-19 infections COVID-19 symptom COVID-19 symptoms detectable develop evaluate Factor HCW HCWs healthcare healthcare worker Healthcare workers humoral Humoral response identify IgG IgG antibodies independent Infection infection with SARS-CoV-2 Interpretation Logistic regression occupational medicine Older positive proportion recruited RT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies serological assays serology serology test Seropositivity seroprevalence survey serum significantly more symptomatic symptomatic and asymptomatic the SARS-CoV-2 was performed [DOI] 10.1093/occmed/kqab061 PMC 바로가기 [Article Type] Article
Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutantsReview Published on 2021-08-122022-11-01 Journal: Clinical Proteomics [Category] COVID-19, [키워드] acute respiratory syndrome anti-viral antibody assays Betacoronavirus clinical study Combination continuous monitoring coronavirus coronavirus disease COVID-19 cross-reactivity diagnostic Diseases Emerging mutations evaluate facilitate functional identify Immunity immunoassays immunoprecipitation information knowledge mass mass spectrometry molecular diagnostics mutant mutations pandemic Pandemics Perspective Population post-translational modifications Protein protein–protein interactions proteomic proteomics quantification rapid response Research RNA sequencing RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serology diagnostics serology test specificity targeted proteomics translational Viral protein Viral RNA viruses while [DOI] 10.1186/s12014-021-09325-x PMC 바로가기 [Article Type] Review
SARS-CoV-2 seroprevalence survey among health care providers in a Belgian public multiple-site hospitalOriginal Paper Published on 2021-08-102022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Analysis antibody Antwerp Belgium Care Contact coronavirus coronavirus disease COVID-19 epidemic wave Evidence Factor Health Health care worker health-care hospital hospitals indicated Infection intensive care units investigated Nurse pandemic performed physician Prevalence professional category questionnaire resource risk risk factor SARS-CoV-2 SARS-CoV-2 seroprevalence SARS-CoV-2 transmission serology test Seroprevalence staff Transmission dynamics working [DOI] 10.1017/S0950268821001497 PMC 바로가기 [Article Type] Original Paper
Miller-Fisher Syndrome Presenting as Facial Diplegia With COVID-19 Co-InfectionEmergency Medicine Published on 2021-08-102022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Ataxia Brain cerebrospinal fluid Computed tomography Coronavirus disease 2019 Course COVID-19 COVID-19 infection demonstrated Diagnosis diplegia etiology facial facial diplegia facial palsy Guillain-Barré syndrome Intravenous immunoglobulin miller-fisher syndrome neurological manifestations Patient physical SARS-COV-2 infection serology test Support supported therapy unique variant [DOI] 10.7759/cureus.17060 PMC 바로가기 [Article Type] Emergency Medicine
Severe acute respiratory syndrome coronavirus 2 reinfection in a coronavirus disease 2019 recovered young adult: a case report중증급성호흡기증후군 코로나바이러스 2 재감염 코로나바이러스 질병 2019 회복된 청년: 사례 보고Case Reports Published on 2021-07-162022-09-10 Journal: Journal of Medical Case Reports [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody back pain Case report Chain Reaction chills concerning constitutional symptoms coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop Fever Healthcare provider healthcare providers healthy immune response immune system Immunity Immunoglobulin immunoglobulins individual ineligible Infection lead management Misconceptions pathophysiology Patient plasma polymerase chain polymerase chain reaction positive positive patients public health threat question raise Reinfection reported Research resolved respiratory SARS CoV-2 serology serology test severe acute respiratory syndrome Coronavirus Side effect supported Symptom Symptoms tested the disease timeline timelines virus while widespread [DOI] 10.1186/s13256-021-02965-5 PMC 바로가기 [Article Type] Case Reports
Performance of the Abbott SARS-CoV-2 IgG II Quantitative Antibody Assay Including the New Variants of Concern, VOC 202012/V1 (United Kingdom) and VOC 202012/V2 (South Africa), and First Steps towards Global Harmonization of COVID-19 Antibody Methods우려의 새로운 변종, VOC 202012/V1(영국) 및 VOC 202012/V2(남아프리카)를 포함한 Abbott SARS-CoV-2 IgG II 정량적 항체 분석의 성능, COVID-19 항체의 글로벌 조화를 향한 첫 단계 행동 양식Immunoassays Published on 2021-07-142022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analytical performance anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody assay Antigen appear binding clinical decision comprehensive evaluation concern Concordance coronavirus correlation COVID-19 COVID-19 pandemic Decision making evaluated Evaluation generate harmonization IgG immune response Including initial initial stages introduced lack linear natural infection New nucleocapsid protein Nucleocapsid proteins parameter performance performed plethora positive protocols Quantitative reference material Reference materials respiratory response reverse transcription-PCR RT-PCR SARS-CoV-2 sensitivity serology serology test severe acute respiratory syndrome Coronavirus South Africa specificity Spike protein Stage step tested the spike protein Trial United Kingdom variants VoC were assessed [DOI] 10.1128/JCM.00288-21 PMC 바로가기 [Article Type] Immunoassays
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern에피토프 특이적 항체 반응으로 COVID-19 결과와 우려 변종 차별화Clinical Medicine Published on 2021-07-082022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료법, [키워드] Action antibody antibody profiling Antibody Response Antibody responses Antibody testing Antigen antigens B.1.1.7 Clinical outcome Clinical severity complex complexity coronavirus COVID-19 detect develop epitope epitope peptide Epitopes foundation Health Sciences high resolution High-resolution Humoral immunity identify immunoassay immunoglobulins Infection Infectious disease Innovation linear epitope linear epitopes London Microarrays Mutation N protein Neutralizing Neutralizing antibodies Non-neutralizing antibodies nucleocapsid ORF organization outcome P681H patient survival peptide peptides plasma sample plasma samples positively correlated predict produced Protein Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome Science screened serology test serology tests specificity the SARS-CoV-2 Toronto university variant variants variants of concern [DOI] 10.1172/jci.insight.148855 PMC 바로가기 [Article Type] Clinical Medicine
SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study건강한 젊은 성인의 SARS-CoV-2 혈청 양성 및 후속 감염 위험: 전향적 코호트 연구Article Published on 2021-07-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Action Analysis antibody baseline COVID-19 COVID-19-related symptom cycle threshold defined Dilution domain effective ELISA enrolled Follow-up full-length spike protein groups hazard ratio healthy home quarantine hotel IgG Immunity incidence rate individuals infected with SARS-CoV-2 Infection infection risk information initial investigated island male mass vaccination medical history men neutralisation activity neutralising neutralising antibody titre observation ORF1 ORF1ab gene participant Participants PCR PCR test person-year positive positive PCR test prospective cohort study Prospective Study Protective quarantine Quarantine period question questionnaire rate ratio Receptor-binding domain response risk Risk factors SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection selected serology test seronegative seronegative participant seronegative participants seropositive seropositive participant seropositive participants Seropositivity serum Spike protein study visit subsequent Swab Symptom tested titre uninfected uninfected participant Vaccination strategies Viral Viral load viral loads was performed were assessed were excluded [DOI] 10.1016/S2213-2600(21)00158-2 PMC 바로가기 [Article Type] Article