Elevated TAT in COVID-19 Patients with Normal D-Dimer as a Predictor of Severe Respiratory Failure: A Retrospective Analysis of 797 PatientsArticle Published on 2021-12-272022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Affect affected age Analysis analyzed BMI body mass index Coagulation complex Coronavirus 2019 COVID-19 D-dimer D-dimer level demonstrated disorder Disseminated intravascular coagulation early stage elevated fibrinogen fibrinolysis group indicate intravascular coagulation logistic regression model male marker normal not affect occur Patient patients with COVID-19 previous study respiratory Respiratory failure Retrospective study SARS-COV-2 infection severe respiratory failure Sex significantly single-center TAT two groups [DOI] 10.3390/jcm11010134 PMC 바로가기 [Article Type] Article
A systematic review and meta-analysis of host genetic factors associated with influenza severityResearch Article Published on 2021-12-202022-10-28 Journal: BMC Genomics [Category] COVID-19, [키워드] 95% CI allele Analysis association disease Effect environmental factors Evidence explained Factor Genes Genetic Genetic polymorphism Genetic variant Genome-wide association study Host identify Influenza influenza infection Influenza severity Interaction investigated marker Meta-analysis Mild symptom opposite pathogen polymorphism populations Result retrieved severe respiratory failure severity stratified supplementary material susceptibility systematic review [DOI] 10.1186/s12864-021-08240-7 PMC 바로가기 [Article Type] Research Article
Association of coronary calcification with prognosis of Covid-19 patients without known heart diseaseResearch Article Published on 2021-12-032022-10-28 Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, SARS, [키워드] acute respiratory symptom adjusted affected age analyzed association Chest computed tomography confounders Coronary artery calcification coronavirus COVID-19 criteria death determine disease evaluate Factor hypertension in-patient independent risk factor less Logistic regression mechanical ventilation men Mild moderate Mortality obese Odds ratio Older Patient positive Prognosis Respiratory failure risk factor RT-PCR severe respiratory failure severity [DOI] 10.1590/1414-431X2021e11681 PMC 바로가기 [Article Type] Research Article
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality중증도 및 사망률에 대한 COVID-19의 주요 공통 유전적 위험 인자의 연령 의존적 영향Clinical Trial Published on 2021-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 변종, 임상, 진단, [키워드] 95% CI Adults age all-cause mortality allele association carrier chromosome chromosome 3 clinical risk Clinical risk factors Cohort Columbia University country COVID-19 COVID-19 patient COVID-19-related complications death died FinnGen Genetic Genetic predisposition genetic risk factor Genetic variation genetics hepatic injury higher odd higher odds Hospitalized implication increased risk individual individual level Interaction Laboratory locus magnitude management morbidity morbidity and mortality Mortality outcome outcomes performed Respiratory failure risk risk allele Risk management severe respiratory failure severity Variability variant Variation Venous Thromboembolism [DOI] 10.1172/JCI152386 PMC 바로가기 [Article Type] Clinical Trial
Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia A Randomized Clinical TrialCOVID-19 폐렴을 가진 입원 환자에서 중증 호흡 부전 또는 사망으로의 진행에 대한 하이 튜터 회복기 혈장의 효과 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-292022-08-13 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI Adverse adverse events age clinical clinical end point clinical trial Composite control group convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia CP and ST CP group CP plus ST CP plus standard therapy death defined did not reduce Effect Efficacy eligible enrolled Enrollment evaluate event experimental group failure finding fraction Glucocorticoids heparin high-titer anti–SARS-CoV-2 CP high-titer CP hospitalized patient hospitalized patients Importance infused intravenous IQR Italy Low–molecular weight heparin maximum measure mechanical ventilation Microneutralization test moderate to severe moderate to severe COVID-19 pneumonia modified intention-to-treat not significantly different objective occurred Odds ratio Open-label oxygen partial pressure participant Patient patients patients with COVID-19 patients with moderate plasma Pneumonia Point primary end point Primary outcome progression randomization randomized clinical trial randomized patient receive recommendations Registration Relevance Remdesivir respiratory Respiratory failure Result setting Severe COVID-19 pneumonia severe respiratory failure ST alone standard care Standard therapy the median treat treated Trial Volume volume of infused CP with COVID-19 worsening worsening respiratory failure [DOI] 10.1001/jamanetworkopen.2021.36246 PMC 바로가기 [Article Type] Randomized Controlled Trial
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers입원 성별 바이오 마커에 의해 SARS-COV-2에 의해 감염된 환자의 호흡기 부전 예측Research Published on 2021-11-222022-08-31 Journal: Biology of Sex Differences [Category] MERS, SARS, 바이오마커, [키워드] 17β-estradiol ACE2 acute respiratory distress acute respiratory distress syndrome Admission affecting analysed Angiotensin1-7 ARDS association Biomarker Biomarkers choice circulating COVID-19 COVID-19 patient COVID-19 severity Definition Deterioration discharged estradiol Estrogen female female patient Female patients females Gender hospital Hospitalization identify lymphocyte Lymphocytes male males neutrophil neutrophil count Occurrence outcome Patient plasma plasma biomarker Plasma level Plasma levels predict predicted Predictive progression respiratory respiratory distress Respiratory failure Result SARS-CoV-2 severe respiratory failure severity Sex Sex difference sex hormone Sex hormones specific biomarker syndrome Testosterone were measured worsening [DOI] 10.1186/s13293-021-00407-x PMC 바로가기 [Article Type] Research
Follow Your Nose: A Key Clue to Understanding and Treating COVID-19당신의 코를 따르십시오: COVID-19를 이해하고 치료하기 위한 핵심 단서Endocrinology Published on 2021-11-182022-09-12 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 진단, [키워드] ACE2 acting activating Activation adverse effect Affect alveolar cell Anosmia anosmia and ageusia Asymptomatic ATP ATP - adenosine triphosphate basolateral compartment benefit biochemical blockade Cell cells complications of COVID-19 control group cough COVID COVID-19 COVID19 patients death determine Dexamethasone Endothelial cell Exocytosis Factor High dose Hypothesis incidence increase Inpatient Long loss of taste low dose dexamethasone lung lysosomal exocytosis mechanism mineralocorticoid receptor Outpatient paracrine parameter Patient patients with moderate PCR-confirmed COVID-19 patients positive result radiological receptor required respiratory responsible SARS-COV-2 infection severe respiratory failure spironolactone and dexamethasone statistically significant stimulate suggested Symptom the SARS-CoV-2 virus treating Treatment understanding vascular permeability were given with COVID-19 [DOI] 10.3389/fendo.2021.747744 PMC 바로가기 [Article Type] Endocrinology
Effect of Intubation Timing on the Outcome of Patients With Severe Respiratory Distress Secondary to COVID-19 PneumoniaAnesthesiology Published on 2021-11-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour acute respiratory distress syndrome [ards] airway intubation Analysis analyzed baseline characteristics benefit Comorbidities coronavirus disease COVID-19 covid-19 respiratory failure Critically ill patient death deteriorate Detroit discharge distress Effect group groups healthcare providers Henry Ford High flow nasal canula higher risk hospital Hospital admission intensive care Intubated intubation Kaplan-Meier Kaplan-Meier survival curves mechanical ventilation Mortality nasal Observational cohort study observé organ dysfunction Organ failure outcome outcomes overall mortality Oxygenation pandemic Patient patients with COVID-19 performed Pneumonia post-hoc analysis Primary outcome question raised reduced risk respiratory respiratory rate Result Resuscitation retrospective risk ROX ROX index secondary secondary to Severe COVID-19 pneumonia Severe respiratory distress severe respiratory failure severe respiratory illness Significant significant difference significantly significantly higher significantly lower significantly more single-center SOFA SOFA score statistically significant difference subgroup of patient survival the timing therapy treated Treatment Ventilation while [DOI] 10.7759/cureus.19620 PMC 바로가기 [Article Type] Anesthesiology
PaO 2 /FiO 2 ratio forecasts COVID-19 patients’ outcome regardless of age: a cross-sectional, monocentric studyIm - Original Published on 2021-10-122022-10-04 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 95% CI Atypical pneumonia AUC calculated clinical clinical outcomes Cohort COVID-19 cross-sectional cut-off value develop highlight identify indicated indication Inflammatory LDH NLR outcome overlapped oxygen support pandemic PaO PaO2/FiO2 ratio parameter Patient Population Predictive recruited Registered SARS-CoV-2 SARS-CoV-2-infected patients score sensitivity severe disease severe respiratory failure specificity supplementary material supportive therapies Trial validation cohort with mild disease World Health Organization [DOI] 10.1007/s11739-021-02840-7 PMC 바로가기 [Article Type] Im - Original
Diphtheria And Tetanus Vaccination History Is Associated With Lower Odds of COVID-19 Hospitalization디프테리아 및 파상풍 예방접종 이력은 코로나19 입원 확률이 낮은 것과 관련이 있습니다Immunology Published on 2021-10-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 백일해, 파상풍, [키워드] age Asymptomatic characterized clinical variation COVID-19 COVID-19 test COVID-19 testing develop diagnosed with COVID-19 Diagnosis Diphtheria explain female Follow-up history immune system immunization individual less Logistic regression Lower manifestation Odds ratio participant Pathogens PROTECT Registered Respiratory disease Result severe COVID-19 severe COVID-19 symptom severe COVID-19 symptoms severe respiratory failure severity of COVID-19 Sex Symptom tested Tetanus UK biobank vaccination Variation [DOI] 10.3389/fimmu.2021.749264 PMC 바로가기 [Article Type] Immunology