Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein423 Published on 2022-01-242022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 antiviral activity binding binding pocket change complement component Compound consequence conserved coronavirus COVID-19 pandemic cysteine decrease disrupt distal disulfide bond disulfide bonds Extracellular host cells human coronavirus human coronaviruses hydrophobic Infection inhibit mechanism mechanism of action membrane permeability nontoxic occur probe RBD reactive reactivity receptor Receptor binding domain receptor binding motif redox biology reducing reduction SARS-CoV-2 shifting Significance significantly spike glycoprotein the RBD the SARS-CoV-2 these compound thiol-based chemical probes Treatment vaccination [DOI] 10.1073/pnas.2120419119 PMC 바로가기 [Article Type] 423
Effects of the COVID-19 pandemic on perinatal outcomes: a retrospective cohort study from Turkey주 산기 결과에 대한 Covid-19 Pandemic의 효과 : 터키의 후 향적 코호트 연구Research Published on 2022-01-202022-09-01 Journal: BMC Pregnancy and Childbirth [Category] 진단, [키워드] addition adjusted affected applied approach Birth weight changed COVID-19 COVID-19 pandemic decrease dependent variables Effect evaluated FIVE Health hospital Hospitalization independent variable independent variables indirect effect indirect effects interaction term LBW lockdown Logistic regression Low birth weight Mode of delivery Modification multivariable analyses multivariable analysis outcome pandemic Pregnancy pregnant Preterm birth proportion reduced reduction in reductions in Region Result retrospective cohort retrospective cohort study shifting significant reductions significantly significantly increased SPSS software suggested supplementary material Turkey [DOI] 10.1186/s12884-021-04349-5 PMC 바로가기 [Article Type] Research
How social learning shapes the efficacy of preventative health behaviors in an outbreakResearch Article Published on 2022-01-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Affect Cohort contagious Course COVID-19 disease risk Effect Efficacy epidemiological global pandemic Government Health heterogeneity individual Infection infection risks Intervention observation observé on type outbreak PROTECT public health reaction recommendations reduce respond shifting virus [DOI] 10.1371/journal.pone.0262505 PMC 바로가기 [Article Type] Research Article
A Pre-Vaccination Baseline of SARS-CoV-2 Genetic Surveillance and Diversity in the United StatesSARS-COV-2 유전자 감시 및 미국의 다양성의 예방 접종 기준Article Published on 2022-01-072022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료제, [키워드] Administered Amino acid amino acid change amino acid changes Analysis conducted COVID-19 COVID-19 vaccine COVID-19 vaccines distributions Diversity expected frequencies Frequency Genetic genetic diversity geographical distributions immune pressure immunologically Infection linkage measure naïve Pathogens pre-vaccination remained RNA virus SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 in United States shifting Spread Support Surveillance the United State uniformity United States variants of concern Viral viral evolution virus spread VOCs widespread [DOI] 10.3390/v14010104 PMC 바로가기 [Article Type] Article
Preferences for Alternative Care Modalities Among French Adults With Chronic IllnessResearch Published on 2021-12-292022-10-29 Journal: JAMA Network Open [Category] Coronavirus, SARS, [키워드] activities activity age calculated Care Characteristics chronic chronic condition Chronic illness clinician collected COVID-19 pandemic criteria examined female finding France French illness implementation Importance individuals IQR measure median modality objective pandemic participant Patient Perceived performed Point preference proportion Relevance remote monitoring replacing reported required Research Result setting shifting Symptom Symptoms Treatment was performed [DOI] 10.1001/jamanetworkopen.2021.41233 PMC 바로가기 [Article Type] Research
COVID-19 mitigation measures to maintain access to essential health services: new opportunities with long-term benefitsCommentary Published on 2021-12-212022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] benefit Contact coronavirus disease COVID-19 COVID-19 mitigation measure Critical Health Health Service Health services health system healthcare highlight impacted IMPROVE maintain measure MONITOR oxygen levels pandemic Patient pulse oximetry reduce shifting task shifting telehealth [DOI] 10.11604/pamj.2021.40.254.31264 PMC 바로가기 [Article Type] Commentary
The role of non–COVID-specific and COVID-specific factors in predicting a shift in willingness to vaccinate: A panel study432 Published on 2021-12-202022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] Affect benefit blunt circulating Community conducted COVID conspiracy beliefs COVID-19 Decline driven by evade expressed facilitate Factor Factors flu vaccination greater Health Health authority identify Immunity individual information International knowledge likelihood media media reliance predicted raised SARS-CoV-2 seasonal flu shifting Significance Spread the disease the United State The United States threshold Trust trust in health experts vaccinate vaccination Vaccination hesitancy vaccination intention Vaccines [DOI] 10.1073/pnas.2112266118 PMC 바로가기 [Article Type] 432
Clinical features of 375 COVID-19 cases imported from Russia through the Suifenhe port and countermeasuresResearch Article Published on 2021-12-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] accounted Admission age Asymptomatic asymptomatic infection baseline body temperature C-reactive protein Chest China clinical Clinical data clinical feature Clinical features Comorbidities Comorbidity cough COVID-19 COVID-19 case COVID-19 patient Critical CRP Disease progression disease severity disease transmission enrolled feature Fever Gender group groups had no High-flow oxygen identify initial symptom lymphocyte majority median age men Mild moderate nasal tube novel coronavirus pneumonia outbreak oxygen Oxygen therapy oxygenation index Patient patients pharyngeal Prevent Result Retrospective study Russia shifting significant difference significantly statistically significant Symptom Symptoms therapeutic therapy undergo WBC White blood cell [DOI] 10.1371/journal.pone.0261437 PMC 바로가기 [Article Type] Research Article
Cross-Cutting Lessons Learned During the COVID-19 Pandemic—the Walter Reed Army Institute of Research ExperienceFeature Article and Original Research Published on 2021-12-042022-10-30 Journal: Military Medicine [Category] COVID-19, [키워드] activate activity added benefit coronavirus disease COVID-19 COVID-19 research COVID-19 vaccine criteria Critical Department detect develop diagnostic capabilities effective effort experience facilitate facilitated Government Health information lesson management material monoclonal antibodies National organization organizations organized overcome pandemic Precaution Prevent required Research Result risk shifting Soldiers Support the disease thematic analysis therapy treat [DOI] 10.1093/milmed/usab438 PMC 바로가기 [Article Type] Feature Article and Original Research
Urban–Rural Partnership Framework to Enhance Food–Energy–Water Security in the Post-COVID-19 EraReview Published on 2021-11-272022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] approach COVID-19 COVID-19 pandemic database disease element food food–energy–water security form framework global goals highlight implication increasingly partnership physical populations public health raised regions Research resource security shifting suggested Support survival Sustainable Development Goals urban–rural partnership widespread [DOI] 10.3390/ijerph182312493 PMC 바로가기 [Article Type] Review